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Major step forward in understanding of viruses as scientists unlock exact structure of Hep A virus

Scientists have announced that for the first time, they have determined the precise atomic structure of the Hepatitis A virus. In an unprecedented step forward, a team of scientists from Beijing and Oxford have been able to map the exact construction of Hepatitis A, down to the individual atoms.... Read More

Researchers Identify Protein That Helps Control Common Viral Infection

Infectious disease specialists at the Johns Hopkins Children’s Center have identified a protein that regulates the body’s immune response to cytomegalovirus (CMV), a common pathogen that causes lifelong infections and can lead to devastating illness in newborns and those with weakened immune sys... Read More

A microbe's fountain of youth

The yeast S.pombe is one of the best-studied microbes in the world. First isolated from East African millet beer over a century ago, it's been used as a model organism in molecular and cell biology for the past sixty years. And yet scientists have now just uncovered what may be its most striking... Read More

Small Things Considered: Fine Reading: Nematodes & HGT

The larger the catalog of sequenced genomes, the greater the chance for seeing horizontal gene transfer (HGT) in action. Although reports of HGT between prokaryotes and eukaryotes have appeared sporadically, it seems that incontrovertible evidence is only beginning to appear now. Indeed, the gen... Read More

Pathogens in Cheese – Researchers Follow the Traces of Deadly Bacteria

If food products are not produced in a hygienic environment, consumers can face the threat of dangerous pathogens. This is exactly what happened in 2009 and 2010 when two different strains of Listeria monocytogenes were found in the traditional Austrian curd cheese known as “Quargel”. 34 people ... Read More

How bacteria with a sweet tooth may keep us healthy

Some gut bacterial strains are specifically adapted to use sugars in our gut lining to aid colonisation, potentially giving them a major influence over our gut health.

We live in a symbiotic relationship with trillions of bacteria in our gut. They help us digest food, prime our immune system ... Read More

Scientists Figure Out How Microbes Make Wine Good

Yeast aren’t the only microbes that help turn boring grapes into the delicious, seductive, complex, confusing, subtle, and totally splendiferous tonic known as wine. In addition to those well-known fermenters, a type of bacteria called Oenococcus oeni (for reasons that will be obvious to oenophi... Read More

Natural History is Dying, and We Are All the Losers

A few weeks ago, I came across a new paper in BioScience called “Natural History’s Place in Science and Society” that contained the following graph.

On the right axis and indicated by the line surrounded by dots is the proportion of introductory biology texts devoted to natural history since ... Read More

Investigating the Cheese Microbiome

We need to understand how diverse communities of microbes interact, but doing so in the gut is hard. Why not turn to a model system, where diverse microbial communities interact, but in an environment that’s easier to study? We have a long history of using model systems in biology – the mice I m... Read More

'Breath test' shows promise for diagnosing fungal pneumonia

Many different microbes can cause pneumonia, and treatment may be delayed or off target if doctors cannot tell which bug is the culprit. A novel approach—analyzing a patient's breath for key chemical compounds made by the infecting microbe—may help detect invasive aspergillosis, a fungal infecti... Read More

A quicker, cheaper way to detect staph in the body

Probe identifies staph bacteria without need for biopsies. Chances are you won’t know you’ve got a staph infection until the test results come in, days after the symptoms first appear. But what if your physician could identify the infection much more quickly and without having to take a biopsy a... Read More

Rare byproduct of marine bacteria kills cancer cells by snipping their DNA

Yale University researchers have determined how a scarce molecule produced by marine bacteria can kill cancer cells, paving the way for the development of new, low-dose chemotherapies.

The molecule, lomaiviticin A, was previously shown to be lethal to cultured human cancer cells, but the mech... Read More

Imaging electric charge propagating along microbial nanowires

Physicists report that they've used a new imaging technique, electrostatic force microscopy, to resolve the biological debate with evidence from physics, showing that electric charges do indeed propagate along microbial nanowires just as they do in carbon nanotubes, a highly conductive human-mad... Read More

Scientists explore the mechanisms of viruses' shells

The genome of viruses is usually enclosed inside a shell called capsid. Capsids have unique mechanic properties: they have to be resistant and at the same time capable of dissolving in order to release the genome into the infected cell. The scientists of the International School for Advanced Stu... Read More

Molecular mechanisms of resistance

The abilities of bacterial organisms to utilize the various strategies to resist antimicrobial compounds are all genetically encoded.

Intrinsic resistance is that type of resistance which is naturally coded and expressed by all (or almost all) strains of that particular bacterial species. An... Read More

Ebola outbreak “out of all proportion” and severity cannot be predicted

A mathematical model that replicates Ebola outbreaks can no longer be used to ascertain the eventual scale of the current epidemic, finds research conducted by the University of Warwick.

Dr Thomas House, of the University’s Warwick Mathematics Institute, developed a model that incorporated da... Read More

Researchers find that going with the flow makes bacteria stick

In a surprising new finding, researchers have discovered that bacterial movement is impeded in flowing water, enhancing the likelihood that the microbes will attach to surfaces. The new work could have implications for the study of marine ecosystems, and for our understanding of how infections t... Read More

How a plant beckons the bacteria that will do it harm

A common plant puts out a welcome mat to bacteria seeking to invade, and scientists have discovered the mat's molecular mix. The study published this week in the Proceedings of the National Academy of Sciences reveals new targets during the battle between microbe and host that researchers can ex... Read More

TWiP 73 letters

Robin writes:


Liquids


Liquids are capable of forming a gas-liquid interface: maintenance of the surface requires adequate pressure in the gas. Adequate in this instance means a gas pressure greater than the vaporisation pressure in the liquid. The gas pressure... Read More

BDP FL maleimide - BODIPY analog - fluorescent labeling of proteins

BDP FL maleimide
http://www.lumiprobe.com/p/bodipy-fl-maleimide

BDP FL maleimide is a bright and photostable thiol-reactive dye for protein labeling, an ideal replacement for fluorescein for microscopy. BDP FL is a borondipyrromethene dye which has absorption and fluorescence spectra similar... Read More

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