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MWV Episode 94 - TWiM #99: Careers in Biodefense
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Small Comfort: Nanomedicine Able to Penetrate Bodily Defenses

Researchers use stealthy nanoscale particles to infiltrate vaginal mucus and keep herpes at bay in mice.

Tears and a runny nose can be unpleasant on a windy day, but these mucosal secretions play a vital role in protecting the body from viruses and other malicious microbes. Unfortunately, muc... Read More

Fermented Fashion via @wabibitotweets @phylogenomics

The Micro'be' project by contemporary textile artist and lecturer Donna Franklin, and scientist Gary Cass, explores fashion and technology's newest frontier: garments made from the bacterial fermentation of wine and beer.

The project's eureka moment came about through a vat of Australian red... Read More

Tending the Body’s Microbial Garden

For a century, doctors have waged war against bacteria, using antibiotics as their weapons. But that relationship is changing as scientists become more familiar with the 100 trillion microbes that call us home — collectively known as the microbiome.

“I would like to lose the language of warfa... Read More

Meningitis Vaccine Being Developed From Common Cold Virus

A leading cause for meningitis and septicemia in the UK is meningococcus B (MenB) bacterium infection. Healthy children can become severely ill within just a few hours if they contract meningitis or septicemia, as both illnesses develop randomly and with alarming speed. It often occurs in babies... Read More

Study upholds immune system’s role in autism

Changes in an overactive immune system can contribute to autism-like behaviors in mice, new research shows.

Scientists at the California Institute of Technology (Caltech) pioneered the study of the link between irregularities in the immune system and neurodevelopmental disorders such as auti... Read More

Microbiologist Uses Viruses to Fight Bacteria

After a decade of research, ContraFect Corporation, a small biotech company based in Yonkers, N.Y., is preparing to test bacteriophages—viruses that infect and destroy bacteria—in people as a potential alternative to overused antibiotics for treating and preventing bacterial infections. The firs... Read More

Aaron J. Shatkin, 77

Aaron J. Shatkin was well known for his work on reoviruses beginning in the 1960s in his laboratory at the Roche Institute of Molecular Biology in Nutley, NJ and then at Rutgers University. He was among the first to appreciate that virus particles contained many different enzymes, such as RNA po... Read More

The Extra Pounds You Can't Afford to Lose: An Interview With Microbiologist Margaret McFall-Ngai

Recent revelations about our microscopic partners and tenants are numerically startling, if not downright existential. Try these for starters: Most of the cells within your body are not human cells, and you are literally teeming with pounds of busy microbes, working to earn their keep while you ... Read More

Rapamycin, Easter Island Drug, Shows Promise In Boosting Aging Brain, Mice Study Shows

Scientists at the University of Texas Health Science Center San Antonio are investigating a potential new drug that could improve learning and memory during aging -- thanks to Easter Island?

The drug, called rapamycin, comes from isolated bacterial products in the soil of the Polynesian islan... Read More

Built-in dengue virus killer found in humans

Scientists may have hit gold in their fight against dengue. They have located a human antibody that can neutralise and kill its virus within two hours.

Significantly, they have also identified a way to reproduce this antibody in large quantities, potentially opening the door to a cure for den... Read More

EP67 Protein May Prevent Flu By Boosting Immune System, Mouse Study Suggests

Scientists may have pinpointed a potential way to prevent the flu by identifying a protein that amps up the immune system, according to a new animal study.

The synthetic protein, called EP67, is able to trigger an immune response to the "threat" of the flu virus within a couple of hours in mi... Read More

In First, Software Emulates Lifespan of Entire Organism

Scientists at Stanford University and the J. Craig Venter Institute have developed the first software simulation of an entire organism, a humble single-cell bacterium that lives in the human genital and respiratory tracts.

The scientists and other experts said the work was a giant step toward... Read More

In First, Software Emulates Lifespan of Entire Organism

Scientists at Stanford University and the J. Craig Venter Institute have developed the first software simulation of an entire organism, a humble single-cell bacterium that lives in the human genital and respiratory tracts.

The scientists and other experts said the work was a giant step towar... Read More

100 trillion good bacteria call human body home

In the search for new life, scientists have studied the depths of the ocean and the lips of steaming volcanoes. They've looked on Mars and the moons of Jupiter, and even planets beyond this solar system.

Dr. David Relman went searching inside his own mouth. On a routine dental visit in 1998, ... Read More

How hosts recognize bacteria

We are surrounded by bacteria, viruses, fungi and parasites. The fact that we nevertheless do not fall prey to infections is thanks to certain cellular sensor molecules such as toll-like receptors (TLR), which recognize the molecular structure of pathogens and intercede by ensuring an often comp... Read More

Bacterial Vaginosis Is Associated with Higher Risk of Female-to-Male Transmission of HIV

An investigation led by UCSF has found that the risk of female-to-male HIV transmission is increased three fold for women with bacterial vaginosis, a common disorder in which the normal balance of bacteria in the vagina is disrupted.

The new research assessed the association between bacterial... Read More

HPV Vaccine Reduces Infection, Even in Unvaccinated: Evidence of 'Herd' Protection

The HPV vaccine not only has resulted in a decrease in human papillomavirus infection in immunized teens but also in teens who were not immunized.

The study is believed to be the first to show a substantial decrease in HPV infection in a community setting as well as herd protection -- a decre... Read More

Selection-driven Gene Loss in Bacteria

Bacterial genomes differ dramatically in size: from 140Kb to 13Mb (those numbers might be off now...please let me know if something has broken the record. Yes, I know the lower estimate can change based on semantics, but there are a bunch in that range). Although we have some clues as to how sel... Read More

Bird Flu Research That Stoked Fears Is Published

The more controversial of two papers describing how the lethal H5N1 bird flu could be made easier to spread was published on Thursday, six months after a scientific advisory board suggested that the papers’ most potentially dangerous data be censored.

The paper’s publication, in the journal S... Read More

Millions of diabetics could die of tuberculosis

A third of the world’s human population is infected with a dormant tuberculosis bacteria, primarily people living in developing countries. The bacteria presents a lifelong TB risk. Recent research out of the University of Copenhagen demonstrates that the risk of tuberculosis breaking out is four... Read More
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