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Rotavirus Activates Lymphocytes from Non-Obese Diabetic Mice by Triggering Toll-Like Receptor 7 Signaling and Interferon Production in Plasmacytoid Dendritic Cells

It has been proposed that rotavirus infection promotes the progression of genetically-predisposed children to type 1 diabetes, a chronic autoimmune disease marked by infiltration of activated lymphocytes into pancreatic islets. Non-obese diabetic (NOD) mice provide a model for the human disease.... Read More

Cilia use different motors for different tasks

Cilia — short, hair-like fibers — are widely present in nature. Single-celled paramecia use one set of cilia for locomotion and another set to sweep nutrients into their oral grooves. Researchers at Brown have discovered that those two cilia sets operate at different speeds when the viscosity of... Read More

Bacteria show surprising number of genetic paths to survival

A boy with cystic fibrosis develops a chronic and potentially deadly Burkholderia dolosa infection in his lungs. Varieties of genetic mutations allow some strains of the bacteria to survive the dual assaults from his immune system and antibiotics, while others perish. Eventually, the strongest m... Read More

Recalling the Good in the Good Old Days

In its early days, ca. 1945-1965, molecular biology was a particularly collegial undertaking, characterized by free sharing of research data and a relative lack of egotistical behavior. The reason for this marvel may well have been that there was so much to discover—so many low hanging fruits—th... Read More

Staph Germs Hide Out In The Hidden Recesses Of Your Nose

Otherwise innocuous bacteria can cause deadly infections when people have surgery or fall ill. To prevent trouble, patients sometimes have their bodies scrubbed clean of Staphylococcus aureus. But it doesn't always work.

That may because the germs thrive in upper recesses of the nose, far fro... Read More

Warmer temperatures push malaria to higher elevations

Researchers have debated for more than two decades the likely impacts, if any, of global warming on the worldwide incidence of malaria, a mosquito-borne disease that infects more than 300 million people each year. University of Michigan ecologists and their colleagues are reporting the first har... Read More

Bacterial Gut Biome May Guide Colon Cancer Progression

Colorectal cancer develops in what is probably the most complex environment in the human body, a place where human cells cohabitate with a colony of approximately 10 trillion bacteria, most of which are unknown. At the 2014 American Association for Cancer Research Annual Meeting in San Diego, re... Read More

Tiny Algae Responsible for Mysterious Fossil Whale Graveyard?

Ever since a highway construction crew in Chile uncovered a fossil graveyard of some 40 prehistoric whales in 2010, with skeletons dating back more than five million years, scientists have wondered why so many giant animals died in one place. This week, a team of them proposed an answer: The hug... Read More

Microbiome in gut, mouth, and skin of low birth weight infants differentiate over first weeks after birth

Low birth weight infants are host to numerous microorganisms immediately after birth, and the microbiomes of their mouths and gut start out very similar but differentiate significantly by day 15 according to a study in mBio this week. Researchers from Stanford University and the University of Pi... Read More

New material improves wound healing, keeps bacteria from sticking

As many patients know, treating wounds has become far more sophisticated than sewing stitches and applying gauze, but dressings still have shortcomings. Now scientists are reporting the next step in the evolution of wound treatment with a material that leads to faster healing than existing comme... Read More

Engineers design ‘living materials’ - Hybrid materials combine bacterial cells with nonliving elements that can conduct electricity or emit light

Inspired by natural materials such as bone — a matrix of minerals and other substances, including living cells — MIT engineers have coaxed bacterial cells to produce biofilms that can incorporate nonliving materials, such as gold nanoparticles and quantum dots.

These “living materials” combin... Read More

UNC researchers discover new target for dengue virus vaccine

Using an experimental technique new to the dengue field, the labs of Ralph Baric, PhD, and Aravinda de Silva, PhD, showed that a molecular hinge where two regions of a protein connect is where natural human antibodies attach to dengue 3 to disable it. The finding, published in the Proceedings of... Read More

Diversity of Antiviral Bacteria Discovered

Wolbachia, a symbiont that resides naturally up to 70% of all insect species, are probably the most prevalent infectious bacteria on Earth. In 2008 Luis Teixeira, now a principal investigator at the Instituto Gulbenkian de Ciência, and other scientists have discovered that Wolbachia can protect ... Read More

Family Tree Of Pertussis Traced, Could Lead To Better Vaccine

Whooping cough was once one of the leading killers of babies around the world. Now that it's largely controlled with a vaccine, scientists have had a chance to figure out how the disease came into being in the first place. That story is told in a study published online this week in the journal m... Read More

Novel vaccine approach to human cytomegalovirus found effective

An experimental vaccine against human cytomegalovirus (CMV) infection, which endangers the developing fetus, organ transplant recipients, patients with HIV and others who have a weakened immune system, proved safe and more effective than previous vaccines developed to prevent infection by the ub... Read More

WHO warns against 'post-antibiotic' era

The 'post-antibiotic' era is near, according to a report released today by the World Health Organization (WHO). The decreasing effectiveness of antibiotics and other antimicrobial agents is a global problem, and a surveillance system should be established to monitor it, the group says. There is ... Read More

New analysis of 'swine flu' pandemic conflicts with accepted views on how diseases spread

The most detailed analysis to date of the spread of the H1N1 2009 pandemic influenza virus, known informally as ‘swine flu’, has found that short-range travel was likely the primary driver for the 2009 pandemic in the United States, in contrast with popularly accepted views on the way diseases s... Read More

A Snippet: Antibiotics In The Nursery

You have heard of the leaf-cutting ants1 that meticulously cultivate "their" fungi2 which provide them with nutrients, and that, in addition, host actinobacteria which prevent bacterial and fungal infections of their fungi as well as their own infection by an entomopathogenic fungus3 Metarhizium... Read More

Scientists Convert Bacteria from Free-living to Nitrogen Fixing

If you pull up a soybean or bean plant and shake off the dirt, you might see odd swellings or bumps, like rheumatic finger joints, on its roots. Inside the cool, soil-covered bumps are bacteria that are making nitrogen with the help of an enzyme, something chemical factories can do only with the... Read More

Research identifies how bacteria produce hydrogen

Making hydrogen easily and cheaply is a dream goal for clean, sustainable energy. Bacteria have been doing exactly that for billions of years, and now chemists at the University of California, Davis, and Stanford University are revealing how they do it, and perhaps opening ways to imitate them.
... Read More

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