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Applications of Clinical Microbial Next-Generation Sequencing - American Academy of Microbiology

The American Academy of Microbiology hosted an event at the National Press Club in February 2016 to disseminate the report, "Applications of Clinical Microbial Next-Generation Sequencing".

A panel of 4 speakers discussed real world applications of NGS and findings from the report, followed b... Read More

Study Shows How Bacteria Evolve in the Lungs of Cystic Fibrosis Patients

Washington, DC – May 24, 2016 – The bacterium Burkholderia multivorans evolves and adapts in bursts to survive in the lungs of cystic fibrosis patients, according to a study published this week in mSystems, an open access journal from the American Society for Microbiology. The work, believed to ... Read More

New gene a key to fighting sepsis

Scientists have identified a gene that could potentially open the door for the development of new treatments of the lethal disease sepsis. Read More

Urinary tract infection: How bacteria nestle in

Almost every second woman suffers from a bladder infection at some point in her life. Also men are affected by cystitis, though less frequently. In eighty percent of the cases, it is caused by the intestinal bacterium E. coli. It travels along the urethra to the bladder where it triggers painful... Read More

What effect does environmental temperature have on bacterial virulence?

A recent tragic die-off of saiga antelope has scientists puzzled about what could cause such a sudden, drastic, large-scale death. Infectious disease could easily be playing a part, with Pasteurella multocida and Clostridium perfringens both possible candidates found in animal necropsies. The su... Read More

Stress wakes up sleeping herpesviruses -- but how?

Hiding their DNA genome inside the nucleus of the infected cells, the herpesviruses establish a lifelong infection in humans. Not well defined stress conditions are known to wake up these parasites from their dormancy - the latent phase - and reactivate the production of new viral progeny, event... Read More

How immunity to RSV develops in childhood but deteriorates in adults

The leading infectious cause of severe respiratory disease in infants, respiratory syncytial virus (RSV), is also a major cause of respiratory illness in the elderly. Approved vaccines do not yet exist, and despite the development of partial immunity following infection during childhood, individ... Read More

Whole-genome sequencing can help ID hospital outbreaks

Drug-resistant infections are becoming one of the scariest epidemics since the advent of antibiotic discovery. Although microbes like methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Klebsiella pneumoniae, and multidrug-resistant Pseudomonas aeruginosa are responsible for... Read More

A microbial mystery in the Namib Desert

The Namib Desert is different than other deserts: it has an unusual geographic feature that differentiates it from most others. This desert (map, right) is where you can find ‘fairy circles,’ or circular areas absent of growth in an already plant-scarce environment. These deadened circles are su... Read More

MGH team broadens utility of more compact CRISPR-Cas9 by increasing its targeting range

A team of Massachusetts General Hospital (MGH) investigators has shown that a method they developed to improve the usefulness and precision of the most common form of the gene-editing tools CRISPR-Cas9 RNA-guided nucleases can be applied to Cas9 enzymes from other bacterial sources. In a paper r... Read More

NIH study finds factors that may influence influenza vaccine effectiveness

The long-held approach to predicting seasonal influenza vaccine effectiveness may need to be revisited, new research suggests. Currently, seasonal flu vaccines are designed to induce high levels of protective antibodies against hemagglutinin (HA), a protein found on the surface of the influenza ... Read More

Dispatches from ASM Microbe - Sunday

We’ve had a whirlwind of amazing talks, poster sessions, and networking sessions so far at ASM Microbe 2016. In our previous two Dispatches from ASM Microbe, we’ve covered microbiomes, for which research ranges from extremely basic (Which microbes are present? How do we quantify them?) to clinic... Read More

Less effective antimalarial therapies can help fight malaria better

Oxford University scientists have found that the more effective way to beat malaria is to use less effective drugs some of the time. Read More

Vaccine against respiratory syncytial virus shows promise in early trial

Johns Hopkins Bloomberg School of Public Health researchers say a new candidate vaccine against respiratory syncytial virus (RSV) made with a weakened version of the virus shows great promise at fighting the disease, the leading cause of hospitalization for children under the age of one in the U... Read More

Scientists, share your Zika virus reagents!

Today I learned that a number of investigators refuse to share their samples of Zika virus with other laboratories.

There are countless stories about scientists not sharing reagents because they want to be the first to make a discovery. This behavior allows them to publish first, secure more ... Read More

Tick tock -- sequencing the tick genome could help defuse the Lyme disease time bomb

The deer tick transmits Lyme disease and other diseases, which cause thousands of human and animal deaths annually. With about 10,000 new patients each year, occurrences of Lyme disease in Switzerland are amongst the highest in Europe, representing a substantial healthcare cost and threatening S... Read More

Tug of war among bacteria

At the University of Cologne, biophysicists in the lab of Professor Berenike Maier were now able to show how differential mechanical forces can lead to cell sorting in biofilms, thereby determining their architecture. In their publication in the journal eLife, the team headed by the biophysicist... Read More

Changing the mindset of a pathogen-based vaccine

It’s hard to turn on the news at the moment and not hear about the latest emerging disease, Zika. The filovirus joins a cadre of infectious diseases spread by arthropod vectors – meaning the disease is passed between infected individuals via insect bites. A long list of microbes are spread this ... Read More

Dengue: Asymptomatic people transmit the virus to mosquitoes

Scientists at the Institut Pasteur in Cambodia, the Institut Pasteur in Paris and the CNRS provided proof that people infected by dengue virus but showing no clinical symptoms can actually infect mosquitoes that bite them. It appears that these asymptomatic people - who, together with mildly sym... Read More

Zika virus: 5 things to know

A concise "Five things to know about.... Zika virus infection" article for physicians highlights key points about this newly emerged virus in CMAJ (Canadian Medical Association Journal) Read More
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