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TWiP 89: Day TWiPers

Vincent, Dickson, and Daniel reveal last week's case study and introduce a new one concerning a patient who traveled to Belize.


Hosts: Vincent Racaniello,&... Read More

Virus-like particle vaccine protects mice from many flu strains

A vaccine that protects against a wide variety of influenza viruses (a so-called universal flu vaccine) is a critical public health goal given the significant rates of illness and death caused by seasonal influenza and the potentially devastating effects of a pandemic influenza strain. Now, rese... Read More

HIV uses the immune system's own tools to suppress it

A Canadian research team at the IRCM in Montreal, led by molecular virologist Eric A. Cohen, PhD, made a significant discovery on how HIV escapes the body's antiviral responses. The team uncovered how an HIV viral protein known as Vpu tricks the immune system by using its own regulatory process ... Read More

TWiV 301: Marine viruses and insect defense

At the International Congress of Virology in Montreal, Vincent speaks with Carla and Curtis about their work on RNA interference and antiviral defense in fruit flies, and viruses in the sea, the greatest biodiversity on Earth.


Host:  Read More

TWiP 88: French foreign lesion

Vincent, Dickson, and Daniel discuss how a secreted protein from the protozoan parasite Theileria transforms its host cells via a cellular proto-oncogene.


Hosts:  Read More

Researchers develop world's most sensitive test to detect infectious disease, superbugs

Infectious diseases such as hepatitis C and some of the world's deadliest superbugs--C. difficile and MRSA among them--could soon be detected much earlier by a unique diagnostic test, designed to easily and quickly identify dangerous pathogens. Read More

Why West Nile virus is more dangerous in the elderly

West Nile virus (WNV) is particularly dangerous in older people, who account for a large number of severe cases and deaths caused by the virus. WNV infection turns serious when the virus crosses the blood-brain-barrier and wreaks havoc among nerve cells in the brain. A study published on July 23... Read More

The sting in dengue's tail

In a new Science study, Duke-NUS Graduate Medical School Singapore (Duke-NUS) scientists have identified how small changes in dengue's viral genome can affect the virus' ability to manipulate human immune defences and spread more efficiently. This research is the first of its kind that examined ... Read More

BacterioFiles 225 - Implanting Internal Invader Immunity

This episode: Don't have immunity? Create your own! Scientists engineer cells to destroy their HIV infections using the bacterial immune system!


(14.5 MB, 15.8 minutes)


Show notes: 
Read More

BacterioFiles 209 - Myxococcus Menace Motivates Megastructures

This episode: Microbial predators in soil cause microbial prey to build fortifications!


(8.8 MB, 9.5 minutes)


Show notes: 
Journal Paper


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Single dose Ebola vaccine is safe and effective in monkeys against outbreak strain

National Institutes of Health (NIH) scientists report that a single dose of an experimental Ebola virus (EBOV) vaccine completely protects cynomolgus macaques against the current EBOV outbreak strain, EBOV-Makona, when given at least seven days before exposure, and partially protects them if giv... Read More

Evolutionary war between microorganisms affecting human health, IU biologist says

BLOOMINGTON, Ind. -- Health experts have warned for years that the overuse of antibiotics is creating "superbugs" able to resist drugs treating infection. Read More

Crime-scene compound may be newest tool in fight against malaria

The compound that detectives spray at crime scenes to find trace amounts of blood may be used one day to kill the malaria parasite. Read More

New smart drug targets and reduces site-specific inflammation

BEER-SHEVA, Israel...July 22, 2015 - Ben-Gurion University of the Negev (BGU) and University of Colorado researchers have developed a dynamic "smart" drug that targets inflammation in a site-specific manner and could enhance the body's natural ability to fight infection and reduce side effects. Read More

TWiM 110 Letters

Trudy writes:


I'm sorry, I may have missed something, but the mechanism behind an effective vaccine is still unclear to me, since infection with F. tularensis does not confer protection. How would a vaccine work?


Katy Bosio replies:


In... Read More

Felinine Plays a Role in the Chasing and Fighting between Cats and Mice

A recent study found that mice may be controlled to be brave in the fight with their biggest enemy cats after smelling a chemical emitted by them and existed in their urine. Read More

TWiP 91: Born to deform

 Vincent, Dickson, and Daniel review how Viagra might be used to block transmission of Plasmodium falciparum, and introduce a new case study.


Hosts:  Read More

Study finds state policies influence vaccination, disease outbreak rates

Athens, Ga. - Lax state vaccination laws contribute to lower immunization rates and increased outbreaks of preventable diseases--like whooping cough and measles--according to a new study from the University of Georgia. Read More

Honoring the Memory of Another

The late Edward Leadbetter had a huge impact on my life as an academic, and a microbiologist. In this post, I try to give some appreciation to what he meant to me. Read More

What's lurking in your lungs? Surprising findings emerge from U-M microbiome research

ANN ARBOR, Mich. -- With every breath you take, microbes have a chance of making it into your lungs. But what happens when they get there? And why do dangerous lung infections like pneumonia happen in some people, but not others? Read More
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