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New understanding of genetic susceptibility to infections by Candida and Mycobacterium

The discovery of bi-allelic mutations in RORC in patients with candidiasis and mycobacteriosis revealed the pivotal role of RORC in mucocutaneous immunity to Candida and in systemic immunity to Mycobacterium in humans. Read More

Stanford researchers genetically engineer yeast to produce opioids

For thousands of years, people have used yeast to ferment wine, brew beer and leaven bread. Now researchers at Stanford have genetically engineered yeast to make painkilling medicines, a breakthrough that heralds a faster and potentially less expensive way to produce many different types of pla... Read More

New Use for Well-known Algae

Shock! Horror! Some treasured molecular paleoenvironmental tools of organic biogeochemists—namely the alkenones, an esoteric group of long-chained compounds made by aquatic microalgae—are being put forward by O’Neil et al.1 as candidates for conversion to jet fuel on an industrial scale! (See... Read More

BacterioFiles 202 - Controlling Coliform Computers

This episode: Programming bacteria to sense and keep genomic records of environmental inputs!


(15.9 MB, 17.4 minutes)


Show notes: 
Read More

TWiV 348: Chicken shift

Hosts: Vincent Racaniello and Rich Condit


Vincent and Rich discuss fruit fly viruses, one year without polio in Nigeria, and a permissive Mar... Read More

Discovery points to a new path toward a universal flu vaccine

Flu vaccines can be something of a shot in the dark. Not only must they be given yearly, there's no guarantee the strains against which they protect will be the ones circulating once the season arrives. Read More

Brown University to help Ghana build HIV, TB research capacity

PROVIDENCE, R.I. [Brown University] -- Tuberculosis is the leading cause of death among HIV-positive Ghanaians, with one study blaming TB for 57 percent of HIV-related deaths in the mid-sized West-African nation. To tackle the problem, a partnership between Brown University and the University of... Read More

Long Distance Travelers Likely Contributing to Antibiotic Resistance's Spread

Washington, DC – August 20, 2015 - Swedish exchange students who studied in India and in central Africa returned from their sojourns with an increased diversity of antibiotic resistance genes in their gut microbiomes. The research is published 10 August in Antimicrobial Agents and Chemotherapy, ... Read More

TWiV 347: Rose rosette and squirrel roulette

Hosts: Vincent RacanielloAlan Dove, and Rich Condit


Vincent, Alan, and Rich discu... Read More

BacterioFiles 188 - Rat Residents Relieve Resin Roughness

This episode: Gut bacteria in Mojave desert woodrats help them detoxify and eat toxic creosote bushes!


(10 MB, 10.8 minutes)


Show notes: 
News item/ Read More

Bacterial Enzyme is Found for a Medical Way of Smoking Cessation

BOC Sciences-There is a new species of bacteria found by scientists from The Scripps Research Institute (TSRI) for a kind of enzyme it produces that can be used as an interfering substance to achieve smoking cessation. This finding will be smokingof considerable significance for its effectivenes... Read More

An Ebolavirus vaccine in Africa

An Ebolavirus vaccine has shown promising results in a clinical trial in Guinea. This vaccine has been in development since 2004 and was made possible by advances in basic virology of the past 40 years. Read More

The Wall of Polio, version 3.0

Back in 2013 I built a Wall of Polio in my laboratory – a large stack of six-well cell culture plates that have been used to measure the concentration of polioviruses in various samples by plaque assay. It became a focal point of the lab at which many guests came to have their photographs taken.... Read More

Newton Fund grant to aid researchers in tackling infectious disease in Malaysia

A group of collaborators led by the University of Southampton have been awarded a British Council Newton Fund Institutional Links Grant to support ground-breaking research towards reducing the burden of infectious disease in Malaysia. Read More

Chickenpox vaccination does increase shingles cases, but mainly in young adults

Vaccinating one-year-olds against chickenpox could temporarily nearly double the incidence of shingles in the wider population, but in younger adults than previously thought. Read More

BacterioFiles 190 - Bacteriophages Bust Biofilm Beacons

This episode: Engineered phages can both kill bacteria and disrupt their communications!


(14.8 MB, 16.2 minutes)


Show notes: 
Journal Paper


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Scripps research-designed drug candidate significantly reduces HIV reactivation rate

HIV-infected patients remain on antiretroviral therapy for life because the virus survives over the long-term in infected dormant cells. Interruption of current types of antiretroviral therapy results in a rebound of the virus and clinical progression to AIDS. Read More

A Toxic Chemical Compound Will be Generated in the Roaster Process of Coffee Beans

BOC Sciencs-Scientists found that a common food additive diacetyl can bring great damage to lungs when it be inhaled. And workers who roast coffee beans and make popcorn have frequent contact with the substance, that's one of the main reason that workers at these post will contract serious lung ... Read More

BacterioFiles 225 - Implanting Internal Invader Immunity

This episode: Don't have immunity? Create your own! Scientists engineer cells to destroy their HIV infections using the bacterial immune system!


(14.5 MB, 15.8 minutes)


Show notes: 
Read More

TWiP 89: Day TWiPers

Vincent, Dickson, and Daniel reveal last week's case study and introduce a new one concerning a patient who traveled to Belize.


Hosts: Vincent Racaniello,&... Read More

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