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Genetic differences may help explain inconsistent effectiveness of anti-HIV drug

Research with human tissue and cells suggests that genetic variations, in addition to failure to comply with treatment regimens, may account for some failures of an anti-HIV drug to treat and prevent HIV infection. Read More

Host Biology in Light of the Microbiome: Ten Principles of Holobionts and Hologenomes

Link: http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.1002226

Groundbreaking research on the universality and diversity of microorganisms is now challenging the life sciences to upgrade fundamental theories that once seemed untouchable. To fully appreciate the change that... Read More

TWiP 90: A carbuncle is a large furuncle

Vincent, Dickson, and Daniel discuss identification of an erythrocyte protein essential for invasion of Plasmodium falciparum, and introduce a new case study.


Hosts:  Read More

Towards an HIV vaccine

Neutralizing antibodies (Nabs) are immune proteins that recognize, bind to, and trigger the elimination of virus before it can establish a chronic infection. How to elicit a potent Nab response capable of protecting against different HIV subtypes and against different modes of infection is criti... Read More

Virus-carrying mosquitoes are more widespread than ever, and spreading

Scientists behind the first global distribution maps of two species of dengue and chikungunya-carrying mosquitoes warn they are spreading to new areas where they could cause disease. Read More

B cell depletion benefits ME/CFS patients

Patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) showed clinical improvement after extended treatment with the anti-B-cell monoclonal antibody rituximab. This result suggests that in a subset of patients, ME/CFS might be an autoimmune disease. Read More

ICAAC 2014 - How Quickly Viruses Can Contaminate a Building

Using tracer viruses, researche... Read More

TWiM #105: Real bugs with legs

Hosts: Vincent RacanielloMichael Schmidt, ... Read More

Prostate Cancer Are Classified Into Five Different Types

Prostate Cancer Are Classified Into Five Different Types
BOC Sciences-Following with the classification of breast cancer, recently prostate cancer is also categorized by its symptoms, which will promote custom treatment and help people who suffer chronically from prostate cancer avoid adverse e... Read More

Flu remedies help combat E. coli bacteria

Trillions of bacteria populate the human gut - which makes them more common than any other cells in our body. The composition of this bacterial population is very variable and influenced by our diet. Diseases, but also antibiotic treatments can induce significant shifts in this equilibrium. If e... Read More

Health-care providers a major contributor to problem of antibiotic overuse

SALT LAKE CITY - 10 percent of health care providers write an antibiotic prescription for nearly every patient (95 percent or more) who walks in with a cold, bronchitis or other acute respiratory infection (ARI), according to a new Centers for Disease Control and Prevention-supported study publi... Read More

HIV grows despite treatment, study finds

HIV can continue to grow in patients who are thought to be responding well to treatment, according to research by the University of Liverpool. Read More

BacterioFiles 203 - P. putida Promotes Plant Pollutant Purification

This episode: Bacteria living in plants could help plants clean up cancer-causing pollutants!


(6.9 MB, 7.5 minutes)


Show notes: 
News item<... Read More

Oxford Ebola vaccine study moves to next phase

Oxford University doctors and scientists are performing the second phase of clinical studies of an experimental Ebola vaccine regimen. The study is part of the EBOVAC2 project, a collaborative programme involving the University of Oxford, French Institute of Health and Medical Research (INSERM) ... Read More

TWiV 305: Rhymes with shinola

Vincent, Alan, and Kathy continue their coverage of the Ebola virus outbreak in West Africa, with a discussion of case fatality ratio, reproductive index, a conspiracy theory, and spread of the virus to the United States.


Hosts:  Read More

BacterioFiles 205 - Colon Community Counterattacks Cholera

This episode: Microbes in the human gut seem to prevent/inhibit cholera!


(10.5 MB, 11.5 minutes)


Show notes: 
Journal Paper

... Read More

THESE YEAST CELLS SAY ‘HI’ AND OTHERS RESPOND

Scientists have engineered yeast cells that can “talk” to one another using a versatile plant hormone called auxin.

Typically, these simple fungal cells (Saccharomyces cerevisiae) usually do their jobs—making bread rise or converting sugar into alcohol—without having to communicate or work to... Read More

Host genetics played a role in vaccine efficacy in the RV144 HIV vaccine trial

July 15, 2012 (SILVER SPRING, Md.) - New findings published today in the journal Science Translational Medicine show that host genetics played a role in protection against HIV infection in the landmark RV144 vaccine trial conducted in Thailand. Read More

Mining Marine Microbes for New Drugs

This slideshow outlines the work of WHOI scientists Tracy Mincer and Kristen Whalen in the quest to beat antibiotic resistance through bioprospecting in the ocean. Read More

A new virus in liver cancer

More than a cause of a simple infection, viruses are often involved in the development of serious diseases. Such is the case with liver cancer, which often develops in an organ that has been weakened by hepatitis B or C virus. Researchers at Inserm, the Paris Public Hospitals (AP-HP), Paris Desc... Read More
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