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Common tuberculosis vaccine can be used to prevent infection as well as disease

The vaccine used to protect against tuberculosis disease, bacillus calmette-guerin or BCG, also protects against tuberculosis infection, mycobacterium, as well as protecting against progression from infection to disease, finds new research. The BCG vaccine has been subject to numerous trials and... Read More

Gut Flora Influences HIV Immune Response

Normal microorganisms in the intestines appear to play a pivotal role in how the HIV virus foils a successful attack from the body’s immune system, according to new research from Duke Medicine.

The study, published Aug. 13, 2014, in the journal Cell Host & Microbe, builds on previous work fro... Read More

Editing HPV's Genes To Kill Cervical Cancer Cells

Researchers have hijacked a defense system normally used by bacteria to fend off viral infections and redirected it against the human papillomavirus (HPV), the virus that causes cervical, head and neck, and other cancers.

Using the genome editing tool known as CRISPR, the Duke University rese... Read More

Drug-Resistant Malaria Spreads Across Southeast Asia

Back in 2008, doctors in Cambodia made a worrisome discovery. They were having a hard time curing some people of malaria.

Even the most powerful drug wasn't clearing out the parasite from patients' blood as quickly as it should. Malaria had evolved resistance to the last medicine we have agai... Read More

Scientists boost potential of passive immunization against HIV

Scientists are pursuing injections or intravenous infusions of broadly neutralizing HIV antibodies (bNAbs) as a strategy for preventing HIV infection. This technique, called passive immunization, has been shown to protect monkeys from a monkey form of HIV called simian human immunodeficiency vir... Read More

Trapped: Cell-invading piece of virus captured in lab by scientists

Scientists try to stay a step ahead of HIV in order to combat drug resistance and to develop better treatments. When a person is infected with HIV, there is an initial burst of virus production. This is when integrase inserts the virus DNA into many human cells, including CD4 T-immune cells, bra... Read More

Watch This Week in Virology Episode 300 Live from ASM HQ Aug 26 7 pm ET

This Week in Virology, the podcast about viruses, celebrates its 300th episode on Tuesday, August 26, 2014 with a live recording at the Washington, DC headquarters of the American Society for Microbiology. This special episode w... Read More

Elusive viral 'machine' architecture finally rendered

Biologists have worked with the Lambda virus as a model system for more than 50 years but they've never had an overarching picture of the molecular machines that allow it to insert or remove DNA from the cells that it infects. Now they can, thanks to an advance that highlights the intriguingly i... Read More

Viral relics show cancer's 'footprint' on our evolution

Cancer has left its 'footprint' on our evolution, according to a study which examined how the relics of ancient viruses are preserved in the genomes of 38 mammal species.

Viral relics are evidence of the ancient battles our genes have fought against infection. Occasionally the retroviruses th... Read More

Experimental Medicine in a Time of Ebola

As the deadly outbreak of Ebola in West Africa continues to claim lives, Wellcome Trust director Dr Jeremy Farrar calls for Africans to be given access to experimental Ebola medication. This joint statement with Prof David Heymann, head of the Chatham House Centre on Global Health Security, and ... Read More

HIV, malaria, and tuberculosis: Success of the Millennium shown in most comprehensive study to date

Accelerated progress against the global burden of HIV, malaria, and tuberculosis (TB) has been made since 2000 when governments worldwide adopted Millennium Development Goal 6 to combat HIV/AIDS, malaria, and TB. New estimates from a major new analysis show that worldwide, the number of people l... Read More

Wild sheep show benefits of putting up with parasites

In the first evidence that natural selection favors an individual's infection tolerance, researchers from Princeton University and the University of Edinburgh have found that an animal's ability to endure an internal parasite strongly influences its reproductive success. Reported in the journal ... Read More

A Symbiont Betrays Its Host

It came as a surprise to me recently to realize how much is known about the immune responses of plants and, moreover, how much there is to know. There is, I found, detailed molecular information about how our botanical cousins defend themselves against the onslaught of infectious agents. Perhaps... Read More

Treating Cancer With Bacteria Shows Real Promise

n a groundbreaking study, researchers say injecting bacteria into a tumor helped shrink it.

Bacteria are generally considered more foe than friend, but that may change, if results from a pioneering study are confirmed.

Reporting in the journal Science Translational Medicine, scientists led... Read More

C. difficile Vaccine Proves Safe, 100 Percent Effective In Animal Models

An experimental vaccine protected 100 percent of animal models against the highly infectious and virulent bacterium, Clostridium difficile, which causes an intestinal disease that kills approximately 30,000 Americans annually. The research is published ahead of print in Infection and Immunity.
... Read More

BacterioFiles 179 - Functionless Phages Feel Fatiguing

 This episode: Defective phages in bacterial genomes can still have burdensome effects! Why do the bacteria keep them around?


(10.4 MB, 11.3 minutes)


Show notes: 
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TWiV 298: MV-NIS de myelo

The TWiV gang answers follow-up questions about the Ebola virus outbreak in West Africa, then discuss treatment of  disseminated multiple myeloma with oncolytic measles virus.


Hosts: Vincent Racaniello... Read More

Native bacteria block Wolbachia from being passed to mosquito progeny

Native bacteria living inside mosquitoes prevent the insects from passing Wolbachia bacteria -- which can make the mosquitoes resistant to the malaria parasite -- to their offspring, according to a team of researchers.

The team found that Asaia, a type of bacteria that occurs naturally in Ano... Read More

Pictures Considered #19. The Basal End of Bacterial Flagella

The end of bacterial flagella that is near the cell is a marvel of mechanical miniaturization — a molecular wheel that turns, just like the axle of a car. The assembly consists of a stator, the part that holds it in place, and a rotor, the part that turns. The rotor is a beautifully complex str... Read More

Oddly Microbial: Selfish Genes*

Evolution is largely driven by conflict, not collaboration, according to cell evolutionist Harmit Malik at the Fred Hutchinson Cancer Research Center (FHCRC). Mammalian cells are contentious places, he explains, populated by alien and host genomic sequences fighting for dominance. "In the compet... Read More
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