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TWiM #125: A minimal cell operating system

A deep sequencing study of commercially available probiotics, and design and synthesis of a minimal bacterial genome are the topics tackled by Vincent, Michael, and Michele on this episode of TWiM.


Hosts: Vincent Racaniello, Read More

Zolav®: A new antibiotic for the treatment of acne

A scientific paper released today in the Journal of Drug Design, Development and Therapy show the effectiveness of Zolav®, a new antibiotic, in treating acne. Read More

Using citizen science to engage students

Scientists and science educators now recognize the value in explaining what fields don’t understand, in addition to facts supported by years of experimental data. Citizen science projects, which emphasize accessibility of scientific technologies and methods for everyone, allow people without yea... Read More

BacterioFiles 247 - Animalcule Acetate Ameliorates Asthma

This episode: Feeding mice high-fiber diets reduces their risk of allergic airway disease, even across generations!


(12.1 MB, 13.2 minutes)


Show notes: 
Read More

Identifying milk components that promote a healthy infant microbiome

Breast milk provides an inexpensive, nutrient-filled source of food for babies. Because of this, the American Academy of Pediatrics and the WHO recommend new mothers to exclusively breast feed their babies for the first six months of life, and continue up to two years (supplemented with other fo... Read More

TWiM 125 Letters

Inspired by William:


Dear TWiMers;
Greetings from Berkeley where miracle March (water-wise) was perhaps half a miracle, but that is definitely better than none. At least we will not run out of water this summer.


I found this quasi-synthetic biology result... Read More

Phage diffusion on a bacterial lawn: not all plaques are created equal

Like us, bacteria have their own microbial attackers, in the form of bacteria-specific viruses called bacteriophage, or phage. These phage come in a variety of flavors but can be broadly categorized into virulent, which immediately begin to replicate and lyse (burst) the infected cell quickly, a... Read More

CDC confirms Zika virus does cause microcephaly

For the first time, US disease experts have agreed that the mosquito-borne Zika virus does indeed cause babies to be born with abnormally small heads — a condition known as microcephaly. Until now, the two conditions were linked — but experts didn’t know for sure if Zika caused the brain-damaged... Read More

Treatment for chronic hepatitis B linked to increased rates of colorectal and cervical cancer

April 15, 2016, Barcelona, Spain: A new study presented today demonstrates a potential link between treatment of long-term oral nucleos(t)ide analogues and an increased risk of colorectal (p=0.029) and cervical (p=0.049) cancer in patients with chronic Hepatitis B virus (HBV). The study results ... Read More

BacterioFiles 248 - Tiny Travelers Transport Toxin Trashers

This episode: Bacteria that swarm around in groups carry other bacteria with them that can be helpful for degrading toxins!


(14.2 MB, 15.5 minutes)


Show notes: 
Read More

TWiV 384: Agent 003, a view to a fish kill

Hosts: Vincent RacanielloDickson DespommierAlan Dove and  Read More

How immunity to RSV develops in childhood but deteriorates in adults

The leading infectious cause of severe respiratory disease in infants, respiratory syncytial virus (RSV), is also a major cause of respiratory illness in the elderly. Approved vaccines do not yet exist, and despite the development of partial immunity following infection during childhood, individ... Read More

BacterioFiles 246 - Prowling Protist Predator Packs

This episode: Amoebas in soil gang up on and eat much larger roundworms!


(10.5 MB, 11.3 minutes)


Show notes: 
Journal Paper
... Read More

Zika virus, like all other viruses, is mutating

Not long after the appearance of an outbreak of viral disease, first scientists, and then newswriters, blame it all on mutation of the virus. It happened during the Ebolavirus outbreak in West Africa, and now it’s happening with Zika virus.

The latest example is by parasitologist Peter Hotez,... Read More

Antiviral therapy prolongs survival in immune tolerant hepatitis B patients

April 15, 2016, Barcelona, Spain: A new study, presented today at The International Liver Congress™ 2016 in Barcelona Spain, demonstrates that the use of antiviral therapy for patients in the immune tolerant phase of Hepatitis B (HBV) prolongs overall survival and reduces the risk of the most co... Read More

Painting with bacteria!

Mixed media artist Maria Peñil Cobo, who was born in Spain and currently resides in Massachusetts, told The Huffington Post on Thursday that she has often turned to nature as inspiration for her artwork. But instead of looking to vast oceans or forest landscapes, it’s the much smaller ecosystems... Read More

TWiP 107: Parasites leave a bad taste in my gut

The TWiPtastic trio solves the case of the Surfer from Switzerland, and reveal how taste-chemosensory tuft cells in the gut regulate immune responses to parasites.


Hosts: Vincent Racaniello,&n... Read More

TWiM #126: I’m not scared of zebrafish and mice and bears (oh my!)

The microbiome of hibernating bears, and zebrafish as a model for bacterial sepsis feature in this animal-centric episode of TWiM hosted by Vincent, Michael, and Michele.


Image: Bright-field (top) and fluorescent (bottom) images of zebrafish embryos infected with E. coli strain F11. E... Read More

New hybrid drug plugs the hole in malaria drug resistance

A combination of artemisinin and another drug (artemisinin combination therapy, ACT) is currently the best malaria treatment recommended by the World Health Organization. In early 2015, artemisinin-resistant malaria was confirmed in five countries in Southeast Asia: Cambodia, Laos, Myanmar, Thai... Read More

Tuberculosis bacteria build 'edible' havens in immune cells

Bacteria that cause tuberculosis trick immune cells meant to destroy them into hiding and feeding them instead. This is the result of a study led by researchers from NYU Langone Medical Center and published online April 18 in Nature Immunology. Read More
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