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Diagnostic guidelines for bloodstream infections aim to shorten time to accurate therapy

One of the most dangerous places for an infection to occur is in the bloodstream. Septicemia, when microbes are present in the blood, not only allows bacteria access to other internal organs through the highway of our circulatory system, but also can cause a massive inflammatory response, leadin... Read More

Reducing infectious malaria parasites in donated blood could help prevent transmission

A technique for reducing the number of infectious malaria parasites in whole blood could significantly reduce the number of cases of transmission of malaria through blood transfusion, according to a collaboration between researchers in Cambridge, UK, and Kumasi, Ghana. Read More

NIH study finds factors that may influence influenza vaccine effectiveness

The long-held approach to predicting seasonal influenza vaccine effectiveness may need to be revisited, new research suggests. Currently, seasonal flu vaccines are designed to induce high levels of protective antibodies against hemagglutinin (HA), a protein found on the surface of the influenza ... Read More

Getting closer to understanding Zika virus, one genome at a time

Several papers published in Genome Announcements recently describe the sequences of new Zika virus isolates. Scientists have known the genomic sequence of at least one Zika virus isolate since 2007, but continue to publish newly isolated strains. What is the importance of these additional sequen... Read More

TWiM #126: I’m not scared of zebrafish and mice and bears (oh my!)

The microbiome of hibernating bears, and zebrafish as a model for bacterial sepsis feature in this animal-centric episode of TWiM hosted by Vincent, Michael, and Michele.


Image: Bright-field (top) and fluorescent (bottom) images of zebrafish embryos infected with E. coli strain F11. E... Read More

TWiM 126 Letters

 


Anthony writes:
An Abandoned Sailor’s Infirmary in NYC Where Cholera Bacteria Was Discovered
http://untappedcities.com/2016/03/... Read More

Yale study suggests immune response to flu causes death in older people, not the virus

New Haven, Conn.-- A new Yale-led study suggests that death from influenza virus in older people may be primarily caused by a damaging immune response to flu and not by the virus itself. The insight could lead to novel strategies for combating flu in the most vulnerable patients, said the resear... Read More

How immunity to RSV develops in childhood but deteriorates in adults

The leading infectious cause of severe respiratory disease in infants, respiratory syncytial virus (RSV), is also a major cause of respiratory illness in the elderly. Approved vaccines do not yet exist, and despite the development of partial immunity following infection during childhood, individ... Read More

Study: Cities have Individual Microbial Signatures

Washington, DC – April 19, 2016 – Cities have their own distinct microbial communities but these communities don’t vary much between offices located in the same city, according to a new study. The work, published this week in mSystems, an open access journal from the American Society for Microbi... Read More

Public health concern as data reveals high prevalence of hepatitis B among refugees in Germany

April 16, 2016, Barcelona, Spain: A new study presented today demonstrates the potential challenge posed to public health systems across Europe as a result of the prevalence of Hepatitis B among new refugee populations. The study was presented at The International Liver Congress™ 2016 in Barcelo... Read More

Pandemic E. coli strain H30 cloaks its stealth strategies

The difficulty in subduing the pandemic strain of drug-resistant E. coli, called H30, may go beyond patient vulnerability or antibiotic resistance. This form of the disease-pathogen may have an intrinsic ability to cause persistent, harmful, even deadly infections. Read More

Moving to Zika Virus

I have worked on polio virus in my laboratory at Columbia University for 35 years. When that virus is eradicated--perhaps in the next few years--we will have to destroy all of our virus stocks. When that happens, I can either go home, or find another virus.

When Zika virus stepped into the w... Read More

An Earth Day Shout-out to Microbes

So another Earth Day has come and gone. How did you spend yours? If you spent the entire day asleep, you used about half a kilogram of oxygen. Since I assume that you are alive and kicking, you probably consumed more oxygen than that. If you went about your normal business during the day, you pr... Read More

Cities have individual microbial signatures

Greg Caporaso was sifting through blog posts on microbe.net, which covers the microbiology of built environments, when a study idea sparked for him and colleagues Jeff Siegel, Scott Kelley and Rob Knight.

“It became clear to me that there was a lot of interesting work being done to understand... Read More

Researcher pioneers bacterial infection treatment using novel target: Vesicles

Bacterial infection takes hold in the body when a pathogenic microorganism delivers toxins to healthy cells. One way bacteria accomplish this is by releasing vesicles, which act as tiny envelopes transporting toxins and other virulence factors to host cells. These toxins allow the bacteria to "m... Read More

Tuberculosis bacteria build 'edible' havens in immune cells

Bacteria that cause tuberculosis trick immune cells meant to destroy them into hiding and feeding them instead. This is the result of a study led by researchers from NYU Langone Medical Center and published online April 18 in Nature Immunology. Read More

BacterioFiles 248 - Tiny Travelers Transport Toxin Trashers

This episode: Bacteria that swarm around in groups carry other bacteria with them that can be helpful for degrading toxins!


(14.2 MB, 15.5 minutes)


Show notes: 
Read More

TWiV 385: Failure

Hosts: Vincent Racaniello and Dickson Despommier


Guest: Stuart Firestein Read More

Identifying milk components that promote a healthy infant microbiome

Breast milk provides an inexpensive, nutrient-filled source of food for babies. Because of this, the American Academy of Pediatrics and the WHO recommend new mothers to exclusively breast feed their babies for the first six months of life, and continue up to two years (supplemented with other fo... Read More

Treatment for chronic hepatitis B linked to increased rates of colorectal and cervical cancer

April 15, 2016, Barcelona, Spain: A new study presented today demonstrates a potential link between treatment of long-term oral nucleos(t)ide analogues and an increased risk of colorectal (p=0.029) and cervical (p=0.049) cancer in patients with chronic Hepatitis B virus (HBV). The study results ... Read More
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