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Despite Superbug Crisis, Progress in Antibiotic Development 'Alarmingly Elusive'

Despite the desperate need for new antibiotics to combat increasingly deadly resistant bacteria, the U.S. Food and Drug Administration (FDA) has approved only one new systemic antibiotic since the Infectious Diseases Society of America (IDSA) launched its 10 x ’20 Initiative in 2010 — and that d... Read More

Recreational use of HIV antiretroviral drug linked to its psychoactivity

Efavirenz (tradenames: Sustiva, Stocrin) is an antiretroviral (ARV) drug commonly used to treat HIV. Its popularity as a medication, alone or more commonly in combination with other HIV medications (tradename: Atripla), is due to its superior effectiveness in suppressing replication of the virus... Read More

Hilary Koprowski, Who Developed First Live-Virus Polio Vaccine, Dies at 96

It was a brew to rival any in “Macbeth.” The main ingredients were rat brain and a fearsome, carefully cultivated virus.

In his laboratory in Pearl River, N.Y., 20 miles north of Manhattan, Dr. Hilary Koprowski macerated the ingredients in an ordinary kitchen blender one January day in 1948. ... Read More

Beer Pong Balls Carry Bacteria, Proving Game Disgusting

Clemson University researchers found that beer pong balls may carry dangerous bacteria, The Associated Press reported.

The balls collected by student researchers from parties over one weekend found salmonella, listeria, E. coli and staph, according to the AP. The study found a high level of b... Read More

TWiV 229: Partly cloudy with a high of H7N9



Hosts: Vincent Racaniello, Rich Condit, Read More

BacterioFiles Micro Edition 122 - Coliforms Consume Caffeine Compulsively

This episode: Scientists engineer E. coli to be addicted to caffeine!




Download Episode (4.3 MB, 4.75 minutes)


Read More

New coronavirus treatable with a mix of antiviral drugs, immune boosters: health experts

When a new disease emerges, scientists and physicians hope something that’s already in the medicine cabinet can be used to treat it.

A new study suggests for the novel coronavirus, that may be the case.

Scientists from the U.S. National Institute of Allergy and Infectious Diseases are repo... Read More

H7N9 Bird Flu Cases In China Rise By Four To 91; Half Have Had No Contact With Poultry

The number of confirmed H7N9 bird flu cases in China increased by four to 91 on Friday. Jiangsu province reported one new case, and Zhejiang province reported three, the state-run Shanghai Daily reported today. The number of dead was unchanged at 17.

An increasing focus among public health ... Read More

TWiP 53 Letters

John writes:


Dear Vincent and Dickson,


I just heard your most recent TWIP. Please keep these podcasts going! I love listening to your podcasts and hearing your enthusiasm for my favorite biological topic, parasites. Remember that for every fan... Read More

TWiP 53: Anti-saliva immunity



Hosts: Vincent Racaniello and Dickson Despommier


Vincent and Dickson discus... Read More

High steaks

Those who take part in clinical trials often have to do nasty things, from taking new drugs to forgoing sleep. Participants in a trial organised by Stanley Hazen of the Cleveland Clinic, in Ohio, had a decidedly easier task: eating steak. After reading Dr Hazen’s conclusions, though, they may be... Read More

Role of Gut Microbiome in Pediatric GI Disease: Evidence Suggestive, But Not Conclusive

Intestinal dysbiosis may play a role in gastrointestinal (GI) disorders such as necrotizing enterocolitis (NEC) and irritable bowel syndrome (IBS) in children, and prebiotics and probiotics may be efficacious for treating these conditions, according to Philip M. Sherman, MD, professor of pediatr... Read More

Modified bacteria could be used in vaccines

A modified strain of Salmonella could be used to efficiently deliver antigens, the key ingredients of vaccines, into human cells, a study suggests.

Salmonella bacteria use nanoscopic needles to inject their own proteins into host cells, enabling them to survive and replicate inside those cell... Read More
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