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Viruses as a Cure

When we talk about viruses, usually we focus on the suffering caused by Ebola, influenza and the like. But our bodies are home to trillions of viruses, and new research hints that some of them may actually be keeping us healthy.

“Viruses have gotten a bad rap,” said Ken Cadwell, an immunologi... Read More

Peptic ulcer, cancer bacteria therapy discovery

A common ingredient in vegetable oils may help reduce infection with a bacterium that can cause stomach cancer and peptic ulcers, according to a study by UC San Diego scientists.

The ingredient, linolenic acid, killed the bacterium Helicobacter pylori in mice and reduced inflammation without ... Read More

Delaying ART in Patients with HIV Reduces Likelihood of Restoring CD4 Counts

A larger percentage of patients with human immunodeficiency virus (HIV) achieved normalization of CD4+ T-cell counts when they started antiretroviral therapy (ART) within 12 months of the estimated dates of seroconversion (EDS) rather than later, according to a report published online by JAMA In... Read More

Schistosomas: Tropical parasite uses swim stroke not shared by any other creature

For many bacteria and parasites looking to get a load of the fresh nutritional bounty inside your body, the skin is the first and most important gatekeeper. Schistosomas, however, and burrow right on through. These waterborne blood flukes, responsible for 200 million total worldwide cases of Sch... Read More

Animals steal defenses from bacteria

It's a dog eat dog world, and bacteria have been living in it for a long time. It's of no surprise that bacteria have a sophisticated arsenal to compete with each other for valuable resources in the environment. In 2010, work led by University of Washington Department of Microbiology Associate P... Read More

New device could make large biological circuits practical

Researchers have made great progress in recent years in the design and creation of biological circuits — systems that, like electronic circuits, can take a number of different inputs and deliver a particular kind of output. But while individual components of such biological circuits can have pre... Read More

BacterioFiles 192 - Susceptibility Separates Streptococcus Strategies

This episode: Pathogenic and non-pathogenic microbes have different strategies for interacting with us, even when they have a common ancestor!


(14.9 MB, 16.3 minutes)


Show notes: 
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TWiV 312: She sells B cells

The TWiVbolans discuss the finding that human noroviruses, major causes of gastroenteritis, can for the first time be propagated in B cell cultures, with the help of enteric bacteria.


Hosts:  Read More

A virus that melts sea stars

Sea stars are lovely marine invertebrates with a round central body connected to multiple radiating legs (photo credit). In the past year millions of sea stars in the west coast waters of North America have melted into piles of slime and ossicles. Sea star associated densovirus might be the caus... Read More

TWiP 79: Across the river and into the trees

Vincent and Dickson discuss the spread of P. knowlesi in Malaysia, and how Leishmania parasites protect the sandfly gut from bacterial infection.


Hosts: Vincent Racaniello and&nbs... Read More

TWiP 79 letters


Jesse writes:


Doctors TWiP,


I came across this paper and thought it sounded interesting for a discussion on TWiP:


Colonisation resistance in the sand fly gut: Leishmania protects Lutzomyia longipalpis from bacterial infection
Read More

VIBRIO CHOLERAE O1 ISOLATEDFROM HUMAN STOOL

THIS IS VIBRIO CHOLERAE O1 OGAWA ISOLATED FROM HUMAN STOOL SWAB PLATED ON BILE SALT AGAR Read More

An Ebola virus protein can cause massive inflammation and leaky blood vessels

Ebola GP protein covers the virus' surface and is shed from infected cells during infection. Shed GP can trigger massive dysregulation of the immune response and affect the permeability of blood vessels.

Click 'source" to read more. Read More

New study reveals why some people may be immune to HIV-1

Natural genetic variation in a protective antiviral enzyme holds promise for new therapies.

Doctors have long been mystified as to why HIV-1 rapidly sickens some individuals, while in others the virus has difficulties gaining a foothold. Now, a study of genetic variation in HIV-1 and in the c... Read More

Flu virus key machine: First complete view of structure revealed

Scientists looking to understand – and potentially thwart – the influenza virus now have a much more encompassing view, thanks to the first complete structure of one of the flu virus’ key machines. Knowing the structure allows researchers to finally understand how the machine works as a whole, a... Read More

Worse Than The Bite

City dwellers across the U.S. might agree on one common enemy: bedbugs. But hey, not to worry, right? "Bedbugs are not known to spread diseases, but bites can be very itchy and irritating." Or so says the New York City Department of Health. But that assertion may not be true. Because a new study... Read More

Why CRISPR Doesn't Work in E. coli

We received this query:

»I enjoyed the article on your blog 'Six Questions About CRISPRs' by Merry Youle. I am an ex-lambdologist, having quit phage lambda in the early 70s and moved to GM-plants. There is one thing about CRISPR that I do not understand: Why did lambdologists not find CRISPR?... Read More

New Tools in Fight Against Virus that Attacks the Brain

Researchers have developed new insight into a rare but deadly brain infection, called progressive multifocal leukoencephalopathy (PML). This disease – which is caused by the JC virus – is most frequently found in people with suppressed immune systems and, until now, scientists have had no effect... Read More

UCI team develops test to rapidly diagnose bloodstream infection

New technology can detect bacterial invaders with unprecedented speed, sensitivity.

A new bloodstream infection test created by UC Irvine researchers can speed up diagnosis times with unprecedented accuracy, allowing physicians to treat patients with potentially deadly ailments more promptly... Read More

Virus devastating sea stars on Pacific Coast identified

Scientists have now explained the mysteriously sudden appearance of a disease that has decimated sea stars on the North American Pacific Coast.

In a paper published Monday, November 17, 2014 in the journal Proceedings of the National Academy of Sciences, Cornell University microbiologist Ian ... Read More
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