Scientists at the University of Massachusetts Medical School (UMMS) have performed the first CRISPR/Cas9 screen to discover human proteins that Zika virus needs for replication. This work, led by Abraham Brass, MD, PhD, assistant professor in microbiology & physiological systems, reveals new lea... Read More
Cold viruses cause us irritation by penetrating into our cells and transporting their RNA into the cytoplasma of the infected cells. This is the only way they can multiply. The details of how the transfer of the RNA from within the virus occurs are difficult to study. However, a new method has b... Read More
For years, researchers have struggled to get a handle on Group B streptococcus (GBS), in the hopes of improving neonatal outcomes. GBS are a bacteria commonly found in the vagina, rectum, and urinary tract of women. In healthy women, the bacteria are commensal, simply living without causing dise... Read More
Washington, D.C.—June 28, 2016—Researchers determined that two bacterial species commonly found in the human mouth and in abscesses, cooperate to make the pathogenic bacterium, Aggregatibacter actinomycetemcomitans, more infectious. Key to the cooperation is that the harmless partner provides th... Read More
Researchers have discovered how the bacteria Group B streptococcus (GBS) avoids detection by the immune system during pregnancy. The findings, reported in the journal mBio, could lead to the development of new drugs and strategies for treating GBS infection, which is a leading cause of neonatal ... Read More
Just like you and me, bacteria have ‘favorite’ foods – though in the case of bacteria, 'favorite' translates to those which are energetically favorable or most accessible. Different bacteria have different preferences, based on their environments and the neighboring microbes that compete for or ... Read More
Vaccination with the anthrax capsule--a naturally occurring component of the bacterium that causes the disease--completely protected monkeys from lethal anthrax infection, according to a study published online this week in the journal VACCINE. These results indicate that anthrax capsule is a hig... Read More
By watching brightly glowing HIV-infected immune cells move within mice, researchers at the Icahn School of Medicine at Mount Sinai have shown how infected immune cells latch onto an uninfected sister cell to directly transmit newly minted viral particles. These interactions allow HIV to spread ... Read More
This episode: Bacteria have repeatedly captured and used the tails of phages to fight each other!
(9 MB, 9.8 minutes)
From ASV 2016 at Virginia Tech, Vincent, Rich and Kathy speak with Stephen Russell about his career and his work on oncolytic virotherapy - using viruses to treat cancers.
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The TWiP trio solve the case of the Woman from Washington Heights, and reveal how helminth infection protects mice deficient in the Crohn's disease gene NOD2 from intestinal disease by inhibiting colonization with an inflammatory bacterial species.
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Things have been quiet on mBiosphere lately. We've been busy updating from ASM Microbe, covering some of the fascinating research presented there. The first Microbe meeting, which combines the former general meeting and ICAAC, was a whirlwind of poster presentations, lectures, seminars, book sig... Read More
So far in this series I’ve written a good deal about our work on Zika virus, but I have said little about the people who are doing the science.
My lab at Columbia University Medical Center is very small, consisting of three people—Amy Rosenfeld, Audrey Warren, and me. Let me tell you about ... Read More
The TWiMers get together at ASM Microbe 2016 in Boston to speak with David and Vanessa to talk about their work on regulation of bacterial virulence in the gut by bacterial adrenergic sensors, and the physiological mechanisms that make us ill and that help us recover.
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Fine pore diffusers are devices that pump air into wastewater in order to stimulate biodegradation of organic matter. Aeration of wastewater incur a large maintenance cost due to the buildup of biofilm, which is one of the biggest costs to the operation of sewage treatment plants. The biofilms ... Read More
After absorbing research on manipulation of the human microbiome, the impact of waterway and agricultural microbiomes, antibiotic resistance spread and the potential of stewardship guard against it, and potential antimicrobial therapies of the future, we have yet to cover an important research t... Read More
This episode: Viruses can cause host cells to inhibit other viruses!
(8 MB, 8.75 minutes)
Vincent and Alan speak with Erica Ollmann Saphire about her career and her work on understanding the functions of proteins of Ebolaviruses, Marburg virus, and other hemorrhagic fever viruses, at ASM Microbe 2016 in Boston, MA.
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We’ve had a whirlwind of amazing talks, poster sessions, and networking sessions so far at ASM Microbe 2016. In our previous two Dispatches from ASM Microbe, we’ve covered microbiomes, for which research ranges from extremely basic (Which microbes are present? How do we quantify them?) to clinic... Read More
ASM Microbe is the new conference that merges the former General Meeting with the Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) to make one microbial sciences-packed meeting with something for everyone. Why institute one new meeting instead of maintaining two separate ... Read More