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NGS-Based Genomic Epidemiology on Livestock MRSA Strain Provides Tools to Predict Future Trajectory

Researchers from the Translational Genomics Research Institute, the Technical University of Denmark, and elsewhere used whole-genome sequence typing to retrace the evolutionary history of a methicillin-resistant Staphylococcus aureus strain currently found in livestock back to its antibiotic-susceptible roots in humans. (GenomeWeb article - subscription needed to read)....

New insights into the genomic anatomy of Escherichia coli O157:H7 outbreaks

A team of U.S. scientists published data presenting the genomic blueprints and outbreak dynamics of the human pathogen Escherichia coli O157:H7 in previously unprecedented detail (new PNAS paper)...

Unraveling genomic code of E. coli bacteria that caused deadly outbreak in Germany

A team led by University of Maryland School of Medicine Institute for Genome Sciences researchers has unraveled the genomic code of the E. coli bacteria that caused the ongoing deadly outbreak in Germany that began in May 2011. To date, 53 people have died in the outbreak that has sickened ...

Video interview about the German E. coli outbreak and international research initiative

Interview with Dr. David Rasko, lead author of paper in NEJM - using latest analytic tools, experts in microbial pathogens decipher strains.

Biotech Now: Podcast interview of Dr. Herve Tettelin Discussing Reverse Vaccinology

Dr. Tettelin, with the Institute for Genome Sciences at the University of Maryland School of Medicine, discusses his research in reverse vaccinology and his pioneering work with pan-genome research. In a podcast produced for BIO 2011, he discusses how DNA sequencing's evolution impacts vaccine development.

Inside Job: Teams of Microbes Pull Strings in the Human Body

You are being manipulated from within by your "frenemies", the microbes.... Tina Saey's article in Science News

Moving pictures of the microbiome

Genome Biology article - Understanding the normal temporal variation in the human microbiome is critical to developing treatments for putative microbiome-related afflictions such as obesity, Crohn's disease, inflammatory bowel disease and malnutrition. Sequencing and computational technologies however have been a limiting factor in performing dense time series analysis of the ...

BBC Interviews about the Human Microbiome

A 30 min radio program about the Human Microbiome Project and some preliminary implications of data on health and disease. Interviews with scientists at NIH, NHGRI, IGS and JCVI.

Human Microbiome Project Data Available to Research Community

The Human Microbiome Project (HMP), funded through the National Institutes of Health Common Fund’s Roadmap for Medical Research, is now releasing reads and assembled sequences from whole metagenome shotgun sequencing of 690 microbiomes and ~ 72 million reads from targeted 16S sequencing of 5034 microbiomes from healthy human subjects for ...

IGS and OpGen Collaborate to Develop Microbial Sequence Database

Today, at ASM, researchers at the Institute for Genome Sciences and OpGen, a whole genome DNA analysis company, announced that they will collaborate to develop a database of high quality, finished, annotated microbial sequences. IGS will provide clinically characterized microbial samples and sequencing data from microbial genomics studies, including from ...
Crops growing in the field can face dramatic changes in temperature, lack of water, or increased salt in the soil resulting from irrigation. Under these stressful conditions crops cannot grow well and their ability to produce seed and fruit is decreased. Because plants cannot move they have evolved genes that ...

The Clinical Push (Genome Web article)

Tracy Vence of GenomeWeb summarizes the connection between the Human Microbiome Project research, metagenomics and clinical implications and applications.

Two new studies seek to validate the results of retracted 2004 paperon parasite-to-host gene transfer

The microparasite that causes Chagas disease really can integrate bits of its genetic material into its host's genome, where it can then be inherited by the host's offspring, according to two studies published in PLoS ONE and PLoS Neglected Tropical Diseases (PLoS NTD).

Research Unlocking the Mysteries Surrounding Lyme Disease

Researchers recently developed novel diagnostic tools able to distinguish between the various strains of bacteria responsible for causing Lyme disease. For more than a decade, only one strain of B. burgdorferi (Lyme bacteria) had been sequenced (mapped), and although that helped research efforts, it was not sufficient to understand the ...

Registration deadline approaching for 11th Genomic Standards Consortium Mtg at Wellcome Trust

The 11th meeting of the Genomic Standards Consortium will be meeting at the Wellcome Trust to discuss the usability of important 'omics data.

11th Genomic Standards Consortium Mtg

The Wellcome Trust will be hosting the next meeting of the Genomic Standards Consortium on April 4 - 6 2011, covering the value of standardized and consistent metadata, functional annotation standards and other topics, which will be held near Cambridge in the UK. For info, please visit www.welcome.ac.uk/conferences.

First Scientific Paper about 2001 Anthrax Investigation Published Today

Researchers at the Institute for Genome Sciences at UMSOM and their collaborators at the FBI, the U.S. Army Medical Research Institute of Infectious Diseases and Northern Arizona University have published the first scientific paper based on their investigation into the anthrax attacks of 2001. The case was groundbreaking in its ...

Combining Microbiological Research Background with Bioinformatics

This is guest blog post i wrote for Biocareers website (for life sciences industry). Its intention is to highlight how people can combine interest in microbiology with growing field of bioinformatics. Comments welcome.

Bioinformatics - Curation Generation

With biological databases growing in size and number, curators are needed to update and correct their contents. For biologists with computer expertise, curating biological data can be ideal combination of their skills....

Decoding Pneumonia's Defenses

Researchers seuquence more than 200 strains of streptococcus pneumoniae and reveal ways that the mircobe evades attempts to defeat it. Findings show how the microbe swaps chunks of DNA with other strains, allowing it to evolve defenses against antibiotics and vaccines. Emily Singer of MIT Technology Review interviews scientists ...

NIAID Grantees Trace Evolution of the Plague

NIAID-funded scientists completed a study on evolution of Yersinia pestis...Researchers analyzed one of the largest collections ever assembled of the bacteria that causes plague.

Whole genome sequence of Borrelia burgdorferi...

Human Lyme disease is caused by a number of related Borrelia burgdorferi sensu lato species. We report here the complete genome sequence of Borrelia sp. isolate SV1 from Finland.

Genomic view of humand and their microbes

Claire Fraser-Liggett's presentation to the American Society for Biochemistry and Molecular Biology's annual meeting titled "The Role of Microbial Communities in Health and Disease", with particular emphasis on microbes in the GI tract.

The Human Microbiome Project & DACC

Dr. Owen White of the Institute for Genome Sciences at the University of Maryland School of Medicine describes how the Data Analysis & Coordination Center supports the Human Microbiome Project, working with sequencing data from microbiology researchers. (info about HMP-DACC is at http://www.hmpdacc.org/)

Microbiological Resilience

Ecological perspective on humans, their microbial and physical environments

Symposium on the Microbiome - the Good, the Bad & the Beautiful

Full day symposium, free to the public, held at Mountcastle Auditorium at Johns Hopkins University. Speakers include Drs. Brendan Cormack, Tom Cebula, Craig Townsend, Cindy Sears, Ying Zhang (all from JHU), Jacques Ravel, Claire Fraser-Liggett, Jim Kaper (IGS & UMSOM), Barak Cohen (Wash U), Dave Newman (NCI) and others. For ...

The Minimum Information about an ENvironmental Sequence" (MIENS)

We present the Genomic Standards Consortium’s (GSC) “Minimum Information about an ENvironmental Sequence” (MIENS) standard for describing marker genes. Adoption of MIENS will enhance our ability to analyze natural genetic diversity across the Tree of Life as it is currently being documented by massive DNA sequencing efforts from myriad ecosystems ...

Chlamydia Basic Society planning annual mtg

The Chlamydia Basic Society is planning their annual meeting in California in March 2011. Abstracts will be accepted until November 30, 2011.

International Team Tracks Plague Pathogen Patterns Using Sequencing and Phylogenetics

A multi-national team of academic, government and industry scientists from Europe, China and the United States published data reconstructing the global evolutional history of devastating plague pandemics in unprecedented detail. This includes the notorious Black Death epidemic in medieval Europe that greatly affected the peoples and governments of Western Civilization. ...

Scientists have determined the genetic structures of the bacteria that causes Lyme disease

Sceintists have made a major achievement toward better understanding Lyme disease, by determining the complete genetic structures of 13 strains of the bacteria that cause the disease. These new discoveries may accelerate research efforts to diagnose, prevent and treat the disease, which can affect the nervous system, heart, ...

"Microbial Communities as Drivers of Ecosystem Complexity" Keystone Symposia

The main purpose of this symposium is to assemble the leaders in the field of environmental microbial ecology and the human microbiome to stimulate interaction and collaboration. Session topics will address every aspect of the study of microbial communities, from microbial surveys, bioinformatics, transcriptomes and proteomics to community modeling. Each ...

Human Microbiome data repository site - HMP DACC

HMP DACC is the Human Microbiome Project's Data Analysis and Coordination Center. A major goal of the HMP is to look for correlations between changes in the microbiome and human health. The HMP DACC is the central repository for all HMP data. More information about the project can be found ...

Dr. Scott Devine discusses


UM IGS Study Finds Vaginal Microbes Vary Among Healthy Women

The delicate balance of microbes in the vagina can vary greatly between healthy women, according to a new study led by the UM’s Institute for Genome Sciences. Researchers hope further study will lead to personalized reproductive medicine for women, allowing doctors to tailor each woman’s treatment and health maintenance strategies ...

ASM's Social Media Presence (PowerPoint) #ASMGM 2010- 2nd Talk - Sarah Pick - Twitter

Some highlights of Twitter in 15 minutes - how scientists might use hashtags, why using Twitter can be good tool, etc

Hunt for genetic causes of diseases narrows targets

The falling cost of genome sequencing has kicked off a new phase in the search for the genetic underpinnings of complex diseases such as asthma, diabetes and autism.... Published in Nature May 18th from the Biology of Genomes meeting in Cold Spring Harbor by Alla Katsnelson

Gates Grand Challenge Grant Awarded

The Institute for Genome Sciences at UMSOM has received a $100,000 Grand Challenges Explorations grant from the Bill & Melinda Gates Foundation. The grant will support an innovative global health research project conducted by Julie Dunning Hotopp, Assistant Professor, titled "Targeting Bacterial Genes Found on Filarial Chromosomes for the Treatment ...

Novartis finds clues for universal E. coli vaccine

Scientists at Novartis have found bacterial components they hope can be used to develop a vaccine to protect people against a range of dangerous E. coli infections. Certain strains of the bacteria cause diseases such as food-borne illnesses, urine infections and meningitis among newborns...

Colorful secret of the pea aphid - NPR interview...

Normally, animals get their DNA from their parents. But a new study shows that they can also get genes from another species. In fact, animals can even take genes from creatures outside of the animal kingdom — like from fungi. And that's pretty surprising. "The idea that animals picked up ...

GSCID funded by NIAID are accepting applications for sequencing projects....

The Genome Sequencing Centers for Infectious Diseases (GSCID), funded by the National Institute of Allergy and Infectious Diseases (NIAID), are accepting applications for sequencing and genotyping projects. The three NIAID-sponsored Genome Sequencing Centers for Infectious Diseases are accepting applications for sequencing and genotyping projects. Investigators are invited to propose projects ...

GEMINA - a web-based system of Genomic Metadata for Infectious Agents

GEMINA is a web-based system to identify infectious pathogens and their representative genomic sequences through selection of associated epidemiology metadata. Gemina supports the development of DNA signature-based assays for the detection of pathogens or sets of pathogen through the Insignia Signature Pipeline at the University of Maryland.
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