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Bacterial virulence factor of mushroom soft rot identified

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Soft rot diseases cause a great deal of damage in agriculture, and turn fruits, vegetables, and mushrooms to mush. By using imaging mass spectrometry together with genetic and bioinformatic techniques (genome mining), German researchers have now discovered the substance the bacteria use to decompose mushrooms. As the scientists report in the journal Angewandte Chemie, the substance called jagaricin could represent a starting point for the development of new antifungal drugs.

Button mushrooms with soft rot develop typical lesions and are eventually completely disintegrate. The pathogen causing soft rot in cultivated mushrooms has been identified as Janthinobacterium agarididamnosum. A team led by Christian Hertweck at the Leibniz Institute for Natural Product Research and Infection Biology in Jena (Germany) wanted to know which bacterial compound is responsible for this destruction in order to better understand the pathobiology and to find possible protective measures. If the soft rot bacteria produce a substance that attacks mushrooms, it is also conceivable that this substance could be effective against microbial fungi, which cause dangerous infections in humans.

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