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Discovery May Shed Light On Why Some HIV-Positive Patients Have More Virus

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Biologists at UC San Diego have unraveled the anti-viral mechanism of a human gene that may explain why some people infected with HIV have much higher amounts of virus in their bloodstreams than others.

Their findings, detailed in a paper in this week’s advance online issue of the journal Nature, could also shed light on the mystery of why some people with HIV never develop symptoms of AIDS. The biologists found that a gene called Human Schlafen 11 produces a protein that inhibits the replication of HIV in infected human cells by blocking the ability of the host cell to synthesize viral proteins.

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