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New proteins inhibit HIV infection in cell cultures

Yale University Cancer Center scientists have developed a new class of proteins that inhibit HIV infection in cell cultures and may open the way to new strategies for treating and preventing infection by the virus that causes AIDS. The findings appear online in the Journal of Virology.

AIDS slowly weakens the immune system and allows life-threatening infections and cancers to thrive. The Yale team isolated six 43- and 44-amino acid proteins that inhibited cell-surface and total expression of an essential HIV receptor and blocked HIV infection in laboratory cell cultures.

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