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How a Common Fungus Knows When to Attack

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The opportunistic fungal pathogen Candida albicans inconspicuously lives in our bodies until it senses that we are weak, when it quickly adapts to go on the offensive. The fungus, known for causing yeast and other minor infections, also causes a sometimes-fatal infection known as candidemia in immunocompromised patients. An in vivo study, published in mBio, demonstrates how C. albicans can distinguish between a healthy and an unhealthy host and alter its physiology to attack.

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mBio - "Variation in Candida albicans EFG1 Expression Enables Host-Dependent Changes in Colonizing Fungal Populations" (http://mbio.asm.org/content/3/4/e00117-12.full)
 
 

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