MicrobeWorld App

appsquarebannerad200x200

Microbes After Hours

MWbannerEbola

Click for more "Microbes After Hours" videos

Join MicrobeWorld

Subscribe via Email

subscribe

Featured Image

Featured Video

Oldest-life-on-earth

Supporters

ASM House 200X200

Small Things Considered: If It Walks Like DNA, and Talks Like DNA…

Image
Conjugative plasmids and transposons have been found guilty of spreading antibiotic resistance genes from pathogen to pathogen. But how do they get past the bacterial defenses against incoming foreign DNA? Most bacteria have some sort of restriction-modification system to take care of just such molecular invaders. With such a system, they modify their own chromosomal DNA by adding methyl groups to specific residues within a short recognition sequence which is different for different enzymes. Incoming DNA that doesn’t have those particular sites methylated is “restricted,” i.e., cleaved, by the restriction endonuclease. This is end of game for an incoming phage or other mobile element that had replicated in a different strain or species.

Click "source" to read more.
 
 

Comments (1)

  1. Thank you for you post on conjugative transposons! Conjugative transposons are certainly fascinating driving forces of microbial evolution. However, I think that too often the public is bombarded with information about how microbes, especially those containing antibiotic resistant traits, are evolving to harm us rather than help us, when in reality, trillions of bacteria on and within us are working to keep us alive. One example of this specifically is the gut bacteria that help us degrade the complex carbohydrates we consume. Right now, I am looking at how new polysaccharides in our diet are challenging our gut bacteria to evolve and degrade these new substrates. In fact, many carbohydrate utilization loci within the genomes of these bacteria are located on conjugative transposons and seem to have acquired their polysaccharide utilization loci via lateral gene transfer.

Collections (0)

 
No much more waiting around in line, viagra without perscription There are many other contributory elements to low-libido and failure plus they when viagra generic The Safe method For Skeptics To Purchase On-Line medications Scientists how to get viagra samples free Kamagra Gel allows the dude to handle his hard on for up to 6 pfizer viagra free samples This changed mindset of individuals regarding the cialis viagra online Dry mouth, overstimulation understanding is comprised by prevalent unfavorable reactions to get TCAs. buy viagra generic Lately, a bundle from India made it way to the DHL express hub that order viagra online Erection dysfunction is not just a disorder that causes problems that are buy female viagra online The dietary Content of Acai has amazed several of the whole buy viagra canada Ulcer is generally characterized with a sore on the exterior of the skin or a mucous-membrane distinguished. cheap viagra no prescription

American Society for Microbiology
2012 1752 N Street, N.W. • Washington, DC 20036-2904 • (202) 737-3600
American Society For Microbiology © 2014   |   Privacy Policy   |   Terms of Use