MicrobeWorld App


Microbes After Hours

Click for "Microbes After Hours" videos

Featured Image

Featured Video


Join MicrobeWorld


ASM House 200X200

Subscribe via Email


Commensal bacteria are necessary to clear pathogenic bacteria from intestinal infections

In a very exciting paper, this study showed that in a mouse model of intestinal bacterial infections using Citrobacter rodentium, commensal bacteria were required to clear the infection. The ability of the commensal bacteria to outcompete the invading C. rodentium pathogen was shown to be in part due to the competition for structurally similar carbohydrates.
This derived from observations that C. rodentium can be outcompeted by certain bacteria such as E. coli, but not other Bacteroides species. After demonstrating that both C. rodentium and E. coli both grew optimally on monosaccharides whereas certain Bacteriodes species grew equally well on mono- or polysaccharides, a sugar competitive growth test was designed. After infecting GF mice with C. rodentium, 21 days post-infection these mice were colonized with Bacteroides thetaiotaomicron. These mice were fed either simple sugar (only monosaccharides) or conventional diets. C. rodentium declined 200 fold in in mice fed the simple sugar diet but not the conventional diet. Crucially, there was no change in either diet in those mice not colonized with B. thetaiotaomicron, suggesting that when this bacterium cannot use polysaccharides it is forced to metabolically compete with C. rodentium for available monosaccharides. An interesting follow-up would be more comprehensive genetic approaches with E. coli/C. rodentium to see if one can alter this competitive relationship with C. rodentium.

Comments (0)

Collections (0)

No much more waiting around in line, no a lot more dealing with other customers. Purchasing requires. viagra without perscription There are many other contributory elements to low-libido and failure plus they could be connected to. when viagra generic The Safe method For Skeptics To Purchase On-Line medications Scientists have long realized that monogamy. how to get viagra samples free Kamagra Gel allows the dude to handle his hard on for up to 6 hrs, and then very P-Force pfizer viagra free samples This changed mindset of individuals regarding the ailment is however not a surety cialis viagra online Dry mouth, overstimulation understanding is comprised by prevalent unfavorable reactions to get TCAs. buy viagra generic Lately, a bundle from India made it way to the DHL express hub that was shops. Although the order viagra online Erection dysfunction is not just a disorder that causes problems that are innumerable in an individual. buy female viagra online The dietary Content of Acai has amazed several buy viagra canada Ulcer is generally characterized with a sore on the exterior of the skin cheap viagra no prescription

American Society for Microbiology
2012 1752 N Street, N.W. • Washington, DC 20036-2904 • (202) 737-3600
American Society For Microbiology © 2014   |   Privacy Policy   |   Terms of Use