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The Antibiotic, Amoxicillin-Clavulanate, Before a Meal May Improve Small Bowel Motility

The common antibiotic, amoxicillin-clavulanate, may improve small bowel function in children experiencing motility disturbances, according to a study appearing in the June print edition of the Journal of Pediatric Gastroenterology and Nutrition from Nationwide Children's Hospital.

Amoxicillan-clavulanate, also known as Augmentin, is most commonly prescribed to treat or prevent infections caused by bacteria. However, it has also been reported to increase small bowel motility in healthy individuals and has been used to treat bacterial overgrowth in patients with chronic diarrhea.

Although amoxicillin-clavulanate seems to mainly affect the small bowel, the mechanisms by which it works are not clear. Dr. Di Lorenzo also says that possible downsides of using amoxicillin-clavulanate as a prokinetic agent include the induction of bacterial resistance, especially from gram negative bacteria such as E.coli and Klebsiella and causing Clostridium difficile induced colitis.

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