In the fight against antibiotic resistance, the next strategy may be to disarm the bacteria without actually killing them.
Published in Nature Structure and Molecular Biology, research led by Monash University shows a protein complex called the Translocation and Assembly Module (TAM), forms a type of molecular pump in bacteria.
The TAM allows bacteria to shuttle key disease-causing molecules from inside the bacterial cell where they are made, to the outside surface, priming the bacteria for infection.
Lead author and PhD student Joel Selkrig of the department of biochemistry and molecular biology says the work paves the way for future studies to design new drugs that inhibit this process.
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