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Researchers closer to the super bug puzzle

Infectious diseases specialists from Austin Health are working closely with Microbiologists from the University of Melbourne to understand how Staph is becoming resistant to all antibiotic therapies.

The treatment of serious infections caused by Staphylococcus aureus (Golden Staph) is complicated by the development of antibiotic resistance. Seriously ill patients, vulnerable to infections can be at additional risk if antimicrobial agents become less effective in fighting infections.

Published today in the journal PLoS Pathogens, a new piece has been added to the puzzle, making the picture clearer. By using whole genome DNA sequencing of strains obtained from patients during persistent blood stream infections, Dr Timothy Stinear and Associate Professor Ben Howden, senior research fellows from the Department of Microbiology and Immunology have discovered how Staph can make one small change to its DNA and then develop resistance to the last-line antibiotic, vancomycin.

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