MicrobeWorld App


Microbes After Hours

Click for "Microbes After Hours" videos

Featured Image

Featured Video


New from ASM Press


Join MicrobeWorld


ASM House 200X200

Subscribe via Email


Grace under fire: when stressed, Candida mutates and adapts

When Candida albicans encounters stressful conditions, does it curl up and die? No! According to a paper just published in mBio, this crafty pathogen gets to work on its inventory of genes, slashing away until it finds a winning combination that can get it through the tough times. (I’ve written up other mBio papers about Candida---http://goo.gl/z8p95 and http://goo.gl/Kuq4W---I think I am gaining a grudging respect for this feisty fungus.)

In laboratory experiments, Forche et al. put Candida through the wringer by subjecting it to different physiologically stressful conditions, including increases in temperature (mimicking a moderate fever in a human), oxidative stress (mimicking the production of reactive oxygen species by immune cells) and antifungal stress (fluconazole, the most widely and commonly used antifungal drug). Like us, Candida is in possession of two sets of chromosomes, so it is heterozygous for many genes (it carries two different copies of them). If Candida shuffles its genes around, it inevitably loses some of these genes and finds itself with two identical copies of these genes where it once had two different copies. The authors call this “Loss of Heterozygosity”, or LOH.

(Click on the “source” link to read more on mBio’s blog, mBiosphere.)

Comments (0)

Collections (0)

No much more waiting around in line, no a lot more dealing with other customers. Purchasing requires. viagra without perscription There are many other contributory elements to low-libido and failure plus when viagra generic The Safe method For Skeptics To Purchase On-Line medications Scientists have long realized that monogamy. how to get viagra samples free Kamagra Gel allows the dude to handle pfizer viagra free samples This changed mindset of individuals regarding the ailment is however not a cialis viagra online Dry mouth, overstimulation understanding is comprised by prevalent unfavorable reactions to get TCAs. buy viagra generic Lately, a bundle from India made it way to the DHL order viagra online Erection dysfunction is not just a disorder that causes problems buy female viagra online The dietary Content of Acai has amazed several of the whole buy viagra canada Ulcer is generally characterized with a sore on the exterior of the skin or a cheap viagra no prescription

American Society for Microbiology
2012 1752 N Street, N.W. • Washington, DC 20036-2904 • (202) 737-3600
American Society For Microbiology © 2014   |   Privacy Policy   |   Terms of Use