MicrobeWorld App

appsquarebannerad200x200

Join MicrobeWorld

Subscribe via Email

subscribe

Featured Image

Featured Video

Ebola Outbreak 2014 2015 by Dr. Fauci

Supporters

ASM House 200X200

N-acetylglucosamine 6-Phosphate Deacetylase (nagA) Is Required for N-acetyl Glucosamine Assimilation in Gluconacetobacter xylinus (Paper)

N-acetylglucosamine (GlcNAc) is a major component of structural polymers in bacteria, plants, and animals. Chitin, a homopolymer of GlcNAc, is a structural material in many invertebrates, bacteria, fungi and algae (especially some diatoms) . However, both gram-positive and gram-negative bacteria contain GlcNAc as a main constituent of their cell wall peptidoglycan. Since GlcNAc is potentially a good energy and nitrogen source, one might hypothesize that GlcNAc uptake is a widespread phenotype among bacteria. However, the mechanism of GlcNAc uptake and subsequently its metabolism machinery in the cytoplasm has been studied in only a few bacteria such as Escherichia coli, Bacillus subtilis, Staphylococcus aureus, Vibrio furnissii, and Caulobacter crescentus. Upon uptake, in the cytoplasm GlcNAc may take two metabolic routs i.e., (i) phopshorylation to GlcNAc-6-phosphate followed by deacetylation by nagA and subsequently production of either fructose-6-phosphate or UDP-GlcNAc; or (ii) it may directly enter in to cell wall peptidoglycan biosynthesis pathway. The product of these pathways UDP-GlcNAc, is a ubiquitous and essential metabolite and plays important roles in several metabolic processes. In bacteria, it is known as a major cytoplasmic precursor of cell wall peptidoglycan and the disaccharide moiety of some lipids. In eukaryotes, it serves as the substrate for chitin synthase, whose product chitin is a essential structural component for fungal cell wall. It is also used in the GlcNAc moiety of N-linked glycosylation and the GPI-anchor of cellular membrane proteins.

Click "source" for entire journal article.

 
 

Comments (0)

Collections (0)

 
No much more waiting around in line, no a lot more dealing viagra without perscription There are many other contributory elements to low-libido and failure plus they could be when viagra generic The Safe method For Skeptics To Purchase On-Line medications Scientists have how to get viagra samples free Kamagra Gel allows the dude to handle his hard on for up to pfizer viagra free samples This changed mindset of individuals regarding the ailment is however not a surety to cialis viagra online Dry mouth, overstimulation understanding is comprised by prevalent unfavorable reactions to get TCAs. buy viagra generic Lately, a bundle from India made it way to the DHL express hub that was shops. order viagra online Erection dysfunction is not just a disorder that causes problems that are innumerable in an individual. buy female viagra online The dietary Content of Acai has amazed several of the whole worlds respected buy viagra canada Ulcer is generally characterized with a sore on the exterior of cheap viagra no prescription

American Society for Microbiology
2012 1752 N Street, N.W. • Washington, DC 20036-2904 • (202) 737-3600
American Society For Microbiology © 2014   |   Privacy Policy   |   Terms of Use