There are 1443 host viral interactions in the NCBI database. These were pumped through a KEGG pathway analsis, providing a useful insight into the multiple processes affected by HIV-1 infection. These include life cycle pathways , endocytosis and the like, but also many immune-related pathways and pathways related to HIV-1 associated pathologies such as dementia or psychosis and other comorbid conditions. Pathogen defense and entry pathways are also well represented.