MicrobeWorld App


Microbes After Hours


Click for more "Microbes After Hours" videos

Join MicrobeWorld

Subscribe via Email


Featured Image

Featured Video

Ebola Virus explained


ASM House 200X200

Bait-and-switch to fight tuberculosis bug: Find out what it needs, then give it something else

A study published in mBio this week highlights a novel approach to developing new antibiotics for tuberculosis and other infections using high-throughput bioinformatics. Lamichhane et al. generated and genotyped over 5,000 strains of M. tuberculosis and used statistical analysis to find putative essential genes. By cross-listing these essential enzymes with a list of their known products, the team identified molecules that may be necessary for the bacterium. They then selected molecules that were chemically similar to those metabolites – but not identical – the idea being that these compounds can function as competitive inhibitors of essential M. tuberculosis enzymes and kill or interfere with the bacterium’s growth. Sort of a bait-and-switch tactic to pump the bacterium full of a compound that is almost but not quite the thing they need.
Click the "source" link to read more on mBio's blog, mBiosphere...

Comments (0)

Collections (0)


American Society for Microbiology
2012 1752 N Street, N.W. • Washington, DC 20036-2904 • (202) 737-3600
American Society For Microbiology © 2014   |   Privacy Policy   |   Terms of Use