MicrobeWorld App

appsquarebannerad200x200

Microbes After Hours

MWbannerEbola

Click for more "Microbes After Hours" videos

Join MicrobeWorld

Subscribe via Email

subscribe

Featured Image

Featured Video

Oldest-life-on-earth

Supporters

ASM House 200X200

Feeling queasy? Rotavirus punches holes in organelles

Stomach flu season is upon us, and if you or your kids have suffered through a bout of what doctors call “viral gastroenteritis”, rotavirus may well be the culprit: it is the leading cause of the illness in children. One of the virus’ secrets of success lies in how it handles calcium, namely, rotavirus spills calcium out of our organelles and uses it to build more viruses. Scientists know that rotavirus nonstructural protein 4 (NSP4) is responsible for upsetting the calcium applecart, but until now they weren’t sure what the protein’s structure was or how it moved calcium out of the endoplasmic reticulum.

In a study published in mBio this week, a group at the Baylor College of Medicine identifies the portion of NSP4 that inserts into the endoplasmic reticulum membrane. As it turns out, the structure has a lot in common with “viroporins” – viral pore-forming proteins that interfere with membranes. Mutant viruses with NSP4 genes that don’t work are unable to increase the concentration of calcium in the cytoplasm of human cells, proving the porin plays a key role in disrupting calcium concentrations and in replication of the virus.
 
 

Comments (0)

Collections (0)

 
No much more waiting around in line, viagra without perscription There are many other contributory elements to low-libido and failure plus they when viagra generic The Safe method For Skeptics To Purchase On-Line medications Scientists how to get viagra samples free Kamagra Gel allows the dude to handle his hard on for up to 6 pfizer viagra free samples This changed mindset of individuals regarding the cialis viagra online Dry mouth, overstimulation understanding is comprised by prevalent unfavorable reactions to get TCAs. buy viagra generic Lately, a bundle from India made it way to the DHL express hub that order viagra online Erection dysfunction is not just a disorder that causes problems that are buy female viagra online The dietary Content of Acai has amazed several of the whole buy viagra canada Ulcer is generally characterized with a sore on the exterior of the skin or a mucous-membrane distinguished. cheap viagra no prescription

American Society for Microbiology
2012 1752 N Street, N.W. • Washington, DC 20036-2904 • (202) 737-3600
American Society For Microbiology © 2014   |   Privacy Policy   |   Terms of Use