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How to crack P. aeruginosa open? Tinker with its porins

Pseudomonas aeruginosa is one tough nut to crack, but a new paper sheds some light on how that cracking might be done, and adds to our knowledge of an opportunistic pathogen that strikes in homes and hospital wards every day.

Unfortunately for patients, P. aeruginosa is able to resist many types of antibiotics and sometimes develops pan-resistance, which enables it to overcome all available therapies. Its secret is in its porin proteins: the cell takes nascent porin proteins and folds the majority of them into practically impermeable two-domain porins. Only a small minority of nascent proteins are folded into the one-domain, permeable type of porin. Before folding, the nascent porins are identical.

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