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Uncovering Secrets Of Salmonella's Stealth Attack

A single crafty protein allows the deadly bacterium Salmonella enterica to both invade cells lining the intestine and hijack cellular functions to avoid destruction, Yale researchers report in the April 17 issue of the journal Cell. This evolutionary slight-of-hand sheds new insights into the lethal tricks of Salmonella, which kills more than 2 million people a year. "In evolutionary terms, this hijacking of cellular machinery to diversify the function of a bacterial protein is mind boggling,'' said Jorge Galan, senior author of the paper and the Lucille P. Markey Professor of Microbial Pathogenesis and Cell Biology and chair of microbial pathogenesis at Yale.
 
 

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