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Automating the survey of protein locations: the trials and tribulations

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An article by Alan Derman, Project Scientist in Joe Pogliano’s lab at the University of California at San Diego, published on the Small Things Considered blog presents a point-by-point analysis of a paper "Quantitative genome-scale analysis of protein localization in an asymmetric bacterium" published in the Proceedings of the National Academies of Science by researchers in the Department of Molecular Biology at Princeton University.

This exhaustive review, in mostly lay person language, really explains the methodology, challenges and triumphs the researchers faced when conducting an encyclopedic survey of protein locations in the bacterium Caulobacter crescentus by automating several of the steps using self-customized technology and techniques.

Click "source" to read the review on Small Things Considered.

 
 

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