TWiV 146: Draco's potion

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Created on Sunday, 28 August 2011 20:49

Written by Vincent Racaniello

Hosts: Vincent Racaniello, Rich Condit, and Abbie Smith

Vincent, Rich, and Abbie review a broad spectrum antiviral protein, and selective pressure applied by a failed HIV-1 vaccine.

Right-click to download TWiV 146 (78 MB .mp3, 107 minutes).

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app.

Links for this episode:

• Broad spectrum antiviral (PLoS One)
• Selection by failed HIV-1 vaccine (Nature Medicine)
• HIV vaccine impacts virus (EurekAlert!)
• TWiV on Facebook
• Letters read on TWiV 146

Weekly Science Picks

Vincent - Hypothetical Risk: Cambridge City Council's Hearings on Recombinant DNA Research
Rich - Z Corporation 3-D printer (YouTube)

Listener Pick of the Week

Jim - Do-it-yourself DNA extraction (Citizen Scientist Quarterly)

Send your virology questions and comments (email or mp3 file) to This email address is being protected from spambots. You need JavaScript enabled to view it. , or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

 

TWiV 145: The inVinceable TWiV

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Created on Wednesday, 17 August 2011 14:53

Written by Vincent Racaniello

Hosts: Alan Dove and Rich Condit

Alan and Rich tackle the discovery of bacteriophages, and treating influenza by calming the cytokine storm.

Right-click to download TWiV 145 (63 MB .mp3, 87 minutes).

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app.

Links for this episode:

• Twort on the nature of ultra-microscopic viruses (Lancet)
• Who discovered bacteriophage? (pdf, Bact Rev)
• Calming cytokine storm to treat influenza (PNAS)
• TWiV on Facebook
• Letters read on TWiV 145

Weekly Science Picks

Alan - AT&T Tech Channel
Rich - Smallpox and its eradication (pdf)

Listener Pick of the Week

Asif - Science Photo Library

Send your virology questions and comments (email or mp3 file) to This email address is being protected from spambots. You need JavaScript enabled to view it. , or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

 

TWiV 144: HIV gets the (zinc) finger

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Created on Sunday, 31 July 2011 15:15

Written by Vincent Racaniello

Hosts: Vincent Racaniello, Rich Condit, and Alan Dove

Vincent, Rich, and Alan discuss live blogging of scientific meetings, the current outbreak of Hendra virus is Australia, and using zinc finger nucleases to make HIV-resistant CD4 cells.

Right-click to download TWiV 144 (75 MB .mp3, 104 minutes).

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app.

Links for this episode:

• Live blogging scientific meetings (virology blog)
• Cross reactive Hendra antibodies in dog (article one and two and three)
• Dog owner replies
• Map of Hendra virus outbreak 2011
• Summaries of current Hendra virus outbreak (one and two)
• Recombinant Hendra glycoprotein vaccine protects ferrets (Vaccine)
• Making HIV resistant CD4 cells with zinc finger nucleases (PLoS Pathogens)
• Surveyor nuclease assay
• NCIS 'Toxic' summary
• TWiV on Facebook
• Letters read on TWiV 144

Weekly Science Picks

Alan - Bugscope
Rich - Vaccine adverse events: Causal or coincidental? (Lancet)
Vincent - West Nile Story by Dickson Despommier (Kindle edition)

Send your virology questions and comments (email or mp3 file) to This email address is being protected from spambots. You need JavaScript enabled to view it. , or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

 

TWiV 143: Live at ASV in Minneapolis

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Created on Sunday, 24 July 2011 15:51

Written by Vincent Racaniello

 

Hosts: Vincent Racaniello, Rich Condit, Julie Overbaugh, and Stacey Schultz-Cherry

Vincent, Rich, Julie and Stacey recorded TWiV at the 30th Annual Meeting of the American Society for Virology in Minneapolis, where they discussed the role of neutralizing antibodies in protection against HIV-1 infection, and astroviruses, agents of gastroenteritis.

Right-click to download TWiV 143 (48 MB .mp3, 66 minutes).

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app.

Links for this episode:

• HIV-1 neutralizing antibodies and risk of infant infection (J Virol)
• Astrovirus increases epithelial barrier (J Virol)
• Virology special reviews issue (open access)
• Don Ganem interrupted by fire alarm at ASV (YouTube)
• History of structural virology
• ASV 2011 at Minneapolis
• Photographs of TWiV at ASV
• Photographs of ASV 2011
• TWiV on Facebook
• Letters read on TWiV 143

Weekly Science Picks

Rich - Iter - building a fusion reactor
Vincent - American girls sweep at Google science fair (NY Times)

Listener Pick of the Week

Jing - Bees by Rudolph Steiner

Send your virology questions and comments (email or mp3 file) to This email address is being protected from spambots. You need JavaScript enabled to view it. , or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

 

TWiV 142: Viral oinkotherapy

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Created on Sunday, 17 July 2011 18:56

Written by Vincent Racaniello

Hosts: Vincent Racaniello, Rich Condit, and Alan Dove

Vincent, Rich, and Alan discuss a method for identifying viruses of individual environmental bacteria, and the using a picornavirus for oncotherapy.

Right-click to download TWiV 142 (69 MB .mp3, 95 minutes).

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app.

Links for this episode:

• Probing individual bacteria for their viruses (Science)
• Looking in vivo at virus-bacterium interactions (ScienceDaily)
• Integrated fluidic circuit (Fluidigm)
• Oncotherapy with Seneca Valley Virus (Clin Cancer Res)
• Epidemiology of Seneca Valley virus (pdf)
• Senecavirus at ViralZone
• Small cell lung cancer (NCBI)
• ECOG performance status
• RECIST
• TWiV on Facebook
• Letters read on TWiV 142

Weekly Science Picks

Alan - Germlines podcast
Rich - science360
Vincent - Google+

Listener Pick of the Week

Angus - Science Weekly with Alok Jha

Send your virology questions and comments (email or mp3 file) to This email address is being protected from spambots. You need JavaScript enabled to view it. , or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

 

TWiV 141: Mickey gets HCV

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Created on Sunday, 10 July 2011 15:42

Written by Vincent Racaniello

Hosts: Vincent Racaniello, Rich Condit,Dickson Despommier,Alan Dove, and Matt Evans

Matt Evans joins Vincent, Rich, Dickson, and Alan to deconstruct a mouse model for hepatitis C virus infection.

Right-click to download TWiV #141 (117 MB .mp3, 97 minutes).

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app.

Links for this episode:

• Mouse model for HCV infection (Nature)
• Commentary on HCV mouse model (Nature)
• Matt Evans on the Wall Street Journal Report
• TWiV on Facebook
• Letters read on TWiV 141

Weekly Science Picks

Matt - Benezra letter to NIH (pdf); (NIH response and Nature commentary)
Dickson - The Big Thirst by Charles Fishman
Alan - Earth's First Steps by Jerry MacDonald
Rich - Final space shuttle launch and NIAID paylines
Vincent - Hertog Global Strategy Initiative

Send your virology questions and comments (email or mp3 file) to This email address is being protected from spambots. You need JavaScript enabled to view it. , or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

 

TWiV 140: An aptitude for microbicides

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Created on Sunday, 03 July 2011 16:21

Written by Vincent Racaniello

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, and Judy Lieberman

Vincent, Alan, Rich, and Judy Lieberman review the use of CD4 aptamer-siRNA chimeras to inhibit HIV transmission.

Right-click to download TWiV #140 (110 MB .mp3, 92 minutes).

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app.

Links for this episode:

• Inhibition of HIV transmission using CD4 aptamer-siRNA chimeras (J Clin Inves)
• Stopping HIV transmission with a molecular barrier? (ScienceDaily)
• An apt approach (Nat Med)
• Smallpox immunization photos (Virus talk)
• TWiV on Facebook
• Letters read on TWiV 139

Weekly Science Picks

Alan - Inside insides
Rich - Rock stars of science
Vincent - A new open-access journal, and Francis Collins on NIH budget

Listener Pick of the Week

Kathy - Scientists and musicians compare notes (NPR)

Send your virology questions and comments (email or mp3 file) to This email address is being protected from spambots. You need JavaScript enabled to view it. , or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

 

TWiV 139: Honey, I shrunk the virus

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Created on Sunday, 26 June 2011 18:20

Written by Vincent Racaniello

Hosts: Vincent Racaniello, Alan Dove, and Dickson Despommier

Vincent, Alan, and Dickson discuss the reduction in genome size of Mimivirus upon passage in amoeba, and analysis of the microbiome of honeybees.

Right-click to download TWiV #139 (96 MB .mp3, 80 minutes).

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app.

Links for this episode:

• Mimivirus genome reduction after amoebal culture (PNAS)
• Carbohydrate-Active enZYmes database
• Analysis of the honey bee microbiome (PLoS One)
• The colony-collapse blues (TWiV 104)
• Blessed are the beekeepers (Wall Street Journal)
• TWiV on Facebook
• Letters read on TWiV 139

Weekly Science Picks

Alan - Life Before the Dinosaurs by ABC
Dickson - Inside Jokes by Matthew M. Hurley
Vincent - The Tree of Life by Jonathan Eisen

Listener Pick of the Week

Lance - A History of the World since 9/11 by Dominic Streatfeild

Send your virology questions and comments (email or mp3 file) to This email address is being protected from spambots. You need JavaScript enabled to view it. , or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

 

TWiV 138: RISCy business with Raul Andino

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Created on Sunday, 19 June 2011 18:09

Written by Vincent Racaniello

Hosts: Vincent Racaniello and Raul Andino

Vincent meets up with Raul Andino in San Francisco to discuss the RNAi-based antiviral defense system of Drosophila, the fruit fly, and how it is antagonized by viruses.

Right-click to download TWiV #138 (53 MB .mp3, 73 minutes).

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app.

Links for this episode:

• Antiviral immunity in Drosophila requires RNAi spread (Nature)
• Cricket paralysis virus antagonizes Argonaute 2 in Drosophila (Nature Struct Biol)
• Dicistroviridae at ViralZone
• TWiV on Facebook

Send your virology questions and comments (email or mp3 file) to This email address is being protected from spambots. You need JavaScript enabled to view it. , or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.

TWiV 137: Look what the dog dragged in

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Created on Sunday, 12 June 2011 22:21

Written by Vincent Racaniello

Hosts: Vincent Racaniello, Alan Dove, Rich Condit, Dickson Despommier, Amit Kapoor, and Ian Lipkin

The TWiV team speaks with Amit Kapoor and Ian Lipkin about how they discovered canine hepacivirus, and its implications for the origin and evolution of hepatitis C virus.

Right-click to download TWiV #137 (69 MB .mp3, 96 minutes).

Subscribe to TWiV (free) in iTunes , at the Zune Marketplace, by the RSS feed, by email, or listen on your mobile device with the Microbeworld app.

Links for this episode:

• Characterization of canine hepacivirus (PNAS)
• Humanized mouse model for HCV (EurekAlert!)
• Summary of CHV study from Mailman School of Public Health
• Center for Infection and Immunity at Columbia University
• TWiV on Facebook
• Letters read on TWiV 137

Weekly Science Picks

Alan - What do marine mammals eat? (YouTube)
Rich - NIH rocket boys
Dickson - Cytomegalovirus needs an antiviral protein (Science)
Vincent - All pdfs free at National Academy of Science Press

Listener Pick of the Week

Adriana and Ye Jung  - The man who was cured of AIDS (article one and two)

Send your virology questions and comments (email or mp3 file) to This email address is being protected from spambots. You need JavaScript enabled to view it. , or call them in to 908-312-0760. You can also post articles that you would like us to discuss at microbeworld.org and tag them with twiv.