TWiV 237: Paleovirology with Michael Emerman

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Created on Sunday, 16 June 2013 15:07

Written by Vincent Racaniello

Hosts: Vincent Racaniello and Rich Condit

Guest: Michael Emerman

Vincent and Rich recorded this episode at the Fred Hutchinson Cancer Research Center in Seattle, WA, where they met up with Michael to talk about his work on the molecular and evolutionary basis of HIV replication and pathogenesis.

Download TWiV 237 (59 MB .mp3, 81 min)

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Links for this episode:

• Ancient origins of SIV (PLoS Path)
• Paleovirology (PLoS Biology)
• Harmit Malik on TWiV 205
• Sara Sawyer on TWiV 193
• Behind the scenes of TWiV 237 - see photos below
• Letters read on TWiV 237

Listener Pick of the Week

Molly - Facts in the case of Dr. Andrew Wakefield

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TWiV 236: Flu gets the VIP treatment

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Created on Sunday, 09 June 2013 13:37

Written by Vincent Racaniello

Hosts: Vincent Racaniello, Alan Dove, and Kathy Spindler

Vincent, Alan and Kathy review novel approaches to preventing influenza virus infection.

Download TWiV 236 (64 MB .mp3, 89 min)

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Links for this episode:

• Ultraprotective influenza vaccine in mice (PNAS)
• Vectored immunoprophylaxis of influenza in mice (Nat Biotech)
• Intranasal antibody gene transfer protects agains influenza (Sci Transl Med)
• Estimating influenza associated deaths (CDC)
• Multistate HAV outbreak (CDC)
• Subscribe to Microbeworld video (YouTube)
• Save podcasting (EFF)
• Letters read on TWiV 236

Weekly Science Picks

Alan - Psychology of antivaccinationists
Vincent -  Virology on Coursera
Kathy - Meteorites through the ages

Listener Pick of the Week

Basel - Self-medication in animals
Sheryl - Noadi's art
Felicity - Survival of the Sickest by Sharon Moalem

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TWiV 235: Live in Edmonton, eh?

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Created on Monday, 03 June 2013 03:27

Written by Vincent Racaniello

Hosts: Vincent Racaniello and Rich Condit

Guests: Dave Evans, Stan Lemon, and Lorne Tyrrell Vincent and Rich recorded this episode before an audience at the 2nd Li Ka Shing Institute of Virology Symposium at the University of Alberta, where they spoke with Dave, Stan, and Lorne about their work on poxvirus vaccines and recombination, an enveloped picornavirus, antivirals against hepatitis B and C viruses, and supporting virology research in Alberta.

Download TWiV 235 (56 MB .mp3, 77 min)

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Links for this episode:

•  Li Ka Shing Institute of Virology
• Alberta Heritage Foundation for Medical Research
• Raised on a farm (YouTube)
• Vaccinia virus strains in Dryvax vaccine (J Virol)
• Vaccinia DNA polymerase and recombination (J Virol)
• Picornavirus hijacks cell membrane (Nature)

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TWiV 234: Live in Denver

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Created on Sunday, 26 May 2013 17:01

Written by Vincent Racaniello

Hosts: Vincent Racaniello and Kathy Spindler

Guests: Nels Elde and Tom Shenk

Vincent and Kathy recorded this episode before an audience at the 2013 General Meeting of the American Society for Microbiology in Denver, Colorado, where they spoke with Nels and Tom about their work on the evolution of virus-host conflict and how viruses influence the cell metabolome.

Download TWiV 234 (58 MB .mp3, 81 min)

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Links for this episode:

•  TWiV 234 behind the scenes photos
• A cross-species view on viruses (Curr Op Virol)
• Pox has got a squeeze box (TWiV 198)
• Saturated fatty acids needed for CMV (PLoS Path)
• CMV and HSV metabolomes differ (PLoS Path)
• Video of this episode - view below

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TWiV 233: We're surrounded

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Created on Sunday, 19 May 2013 16:07

Written by Vincent Racaniello

Hosts: Vincent Racaniello, Rich Condit, Alan Dove, and Kathy Spindler

Vincent, Rich, Alan and Kathy review aerosol transmission studies of influenza H1N1 x H5N1 reassortants, H7N9 infections in China, and the MERS coronavirus.

Download TWiV 233 (71 MB .mp3, 98 min)

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Links for this episode:

• Aerosol transmission of H1N1 x H5N1 reassortants (Science)
• It's good science (virology blog)
• Viral engineering dangers (Nature)
• Colorblind web page filter
• Influenza H7N9 update (ProMedMail)
• Influenza H7N9 risk assessment (WHO, pdf)
• Influenza H7N9 confirmed cases (WHO)
• New coronavirus gets a new name (ScienceInsider)
• Novel coronavirus infection update (WHO)
• Coronavirus infections (WHO)
• Letters read on TWiV 233

Weekly Science Picks

Alan - Space Oddity (YouTube)
Rich - Walk through giant colon
Vincent -  Transport proteins
Kathy - Vomiting Larry (YouTube)

Listener Pick of the Week

Tom - US patent system is broken (DailyTech)

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TWiV 232: Gophers go viral

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Created on Sunday, 12 May 2013 18:32

Written by Vincent Racaniello

Hosts: Vincent Racaniello, Roberto Cattaneo, Reuben Harris, Lou Mansky, and Leslie Schiff

Vincent meets up with Roberto, Reuben, Lou, and Leslie at the University of Minnesota to talk about their work on HIV-1, APOBEC proteins, measles virus, and teaching virology to undergraduates.

Download TWiV 232 (60 MB .mp3, 84 min)

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Links for this episode:

• University of Minnesota virology timeline
• Virology and Gene Therapy track at Mayo Clinic
• Revisiting HIV-1 lethal mutagenesis (Trends Micro)
• Exploiting HIV-1 drug repositioning (J Virol)
• 5-azaC induces HIV-1 lethal mutagenesis (J Virol)
• HIV-1 fitness and mutation rate (J Mol Biol)
• APOBEC3 mutagenesis in breast cancer (Nature)
• Restriction factors of HIV (J Biol Chem)
• Nectin-4 is epithelial measles receptor (Nature)
• Photographs of this episode: Click here
• Video of this episode - view below

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TWiV 231: Hepaciviruses and pegiviruses in bats and rodents

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Created on Sunday, 05 May 2013 16:25

Written by Vincent Racaniello

Hosts: Vincent Racaniello, Amit Kapoor, Lan Quan, and Ian Lipkin

Vincent meets up with Amit, Lan, and Ian to discuss their discovery of hepaciviruses and pegiviruses in bats and rodents.

Download TWiV 231 (55 MB .mp3, 76 min)

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Links for this episode:

•  Canine hepacivirus (TWiV 137)
• Rodent homologs of hepaciviruses and pegiviruses (mBio)
• Bats are a reservoir of hepaciviruses and pegiviruses (PNAS)

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TWiV 230: Gene goes to Washington, flu chickens out

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Created on Sunday, 28 April 2013 15:19

Written by Vincent Racaniello

Hosts: Vincent Racaniello, Rich Condit, Alan Dove, and Kathy Spindler

Vincent, Rich, Alan and Kathy review H7N9 infections in China, the debate over patenting genes, and receptor-binding by ferret-transmissible avian H5 influenza virus.

Download TWiV 230 (73 MB .mp3, 101 min)

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Links for this episode:

• Francois Jacob dies (The Loom)
• WHO updates on H7N9
• H7N9 is unusually dangerous (ScienceInsider)
• H7N9 case imported into Taiwan
• No H7N9 in poultry farms (Xinhua)
• Supreme Court considers gene patents (TheScientist, Nature)
• Patent my jeans, not my genes (Michael Wosnick)
• Receptor binding by ferret transmissible H5 virus (Nature)
• Microscale thermophoresis and bio-layer interferometry (Wikipedia)
• Letters read on TWiV 230

Weekly Science Picks

Alan - World Science Festival
Rich - 3 years of the sun in 3 minutes
Vincent -  The Origin of AIDS by Jacques Pepin
Kathy - Wringing out a wet washcloth in space (YouTube)

Listener Pick of the Week

Mark - Will it blend? (iPhone app)
Marianne - Enjoy your Cells

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TWiV 229: Partly cloudy with a high of H7N9

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Created on Sunday, 21 April 2013 14:08

Written by Vincent Racaniello

Hosts: Vincent Racaniello, Rich Condit, Dickson Despommier, and Alan Dove

Vincent, Rich, Dickson, and Alan review the current status of human infections with avian influenza H7N9 virus.

Download TWiV 229 (69 MB .mp3, 95 min)

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Links for this episode:

• Hilary Koprowski, 96 (NY Times)
• Koprowski, Kessin, Racaniello photo
• Listen to the Music by Roger Vaughan
• Influenza ocular infections (one, two)
• H7N9 global concerns (NEJM)
• Human infection with H7N9 (NEJM)
• WHO Global Alert and Response, H7N9
• Avian influenza A(H7N9) virus (WHO)
• Novel H7N9 reassortant, implications for Europe (Eurosurveill)
• Genetic analysis of H7N9 (Eurosurveill)
• H7N9 compared with H7N7 outbreaks (Eurosurveill)
• Image credit: Eurosurveillance
• Letters read on TWiV 229

Weekly Science Picks

Alan - Nature PastCast
Rich - How dengue does it
Vincent -  Squeaky Squeegee Art by Deb Sklut
Dickson - Agritecture

Listener Pick of the Week

Mike - Chemistry in its element: Elements and Compounds

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TWiV 228: Cal Bears go viral

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Created on Sunday, 14 April 2013 23:56

Written by Vincent Racaniello

Hosts: Vincent Racaniello, Britt Glaunsinger, and Eva Harris

Vincent visits the University of California at Berkeley and speaks with Britt Glaunsinger and Eva Harris about their work on Kaposi's sarcoma associated herpesvirus and dengue virus.

Thanks to the Microbiology Graduate Students for hosting me at their annual symposium, and especially to Emma, Lisa, and Zoe for their wonderful hospitality during my stay.

Download TWiV 228 (49 MB .mp3, 68 min)

Subscribe (free): iTunes, RSS, email

Links for this episode:

• RNA element in IL-6 confers SOX resistance (J Virol)
• Dual uORFs regulate herpesviral translation (PLoS Path)
• Common viral strategy for RNA degradation (J Virol)
• KSHV SOX and Xrn1 together degrade host mRNAs (PLoS Path)
• Dengue treatment with Fc null antibodies (PLoS Path)
• Early clinical features of dengue in Nicaraguan children (PLoS Negl Trop Dis)
• Intrahuman dengue virus diversity (J Virol)
• Dynamics of dengue disease severity (Sci Transl Med)

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