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Zika virus in Brazilian non-human primates

Zika virus RNA has been detected in New World monkeys from the Northeast region of Brazil. This finding suggests that primates may serve as a reservoir host for the virus, as occurs in Africa. Read More

Systems study of climate change effects, large and small

If there is a problem built for a systems-based research approach, climate change – with its complex carbon and nitrogen cycles, numerous species involvement, and interaction of geographical zones – would be an excellent candidate. Concurrent with the launch of the systems-based microbial resear... Read More

TWiM #127: Subway Snowblowers and Men in Black

The TWiM team explores microbes in snowblower vents on the ocean floor, and cleavage of antibody molecules by a Mycoplasma protease.


Image (right): Photograph of the ‘Subway’ snowblower vent on the sea floor at Axial Seamount, Juan de Fuca Ridge. Visible are white ‘snow’ in the vent a... Read More

Enhanced virus transduction may lead to more effective gene therapy

A benefit of the voluminous wealth of research produced is that it allows us to stand on the shoulders of giants – we can take advantage of established facts, tools, and datasets. This may mean using a mutant library to find genes in your organism that are important for the process you study; ac... Read More

Zika virus

The rapid spread of Zika virus through the Americas, together with the association of infection with microcephaly and Guillain-Barré syndrome, have propelled this previously ignored virus into the limelight. What is this virus and where did it come from?
Read More

Meta-analysis of urine pre-analytic practice reveals need for rigorous studies

Evidence-based medicine is the approach used by doctors to make rational clinical decisions based on rigorous, well-controlled studies. By minimizing hunches, gut feelings, and anecdotal evidence, physicians and patients can follow recommendations that are most likely to have a positive outcome.... Read More

Fighting viruses - amazing new 21st century lab

Looking out of the window isn’t something most office workers would consider a luxury. But then, most people don’t work in a maximum security, biosafety level 4 high-containment research facility, working to protect the UK’s multi-billion pound agricultural industry from dangerous and highly inf... Read More

Moving beyond metagenomics to find the next pandemic virus

I was asked to write a commentary for the Proceedings of the National Academy of Sciences to accompany an article entitled SARS-like WIV1-CoV poised for human emergence. I’d like to explain why I wrote it and why I spent the last five paragraphs railing against regulating gain-of-function experi... Read More

Ancient clay remedy proves its antibacterial powers in the lab

Near Kisameet Bay on the central coast of British Columbia sits a deposit of clay that covers 5 acres and spans a depth up to 42 feet in places. This vast smear formed 10,000 years ago as glacial melt filled a granite basin and fine minerals silted out.

The ancient clay likely holds secrets t... Read More

Scientists prove key aspect of evolutionary theory

Evolutionary theory predicts that pairs of chromosomes within asexual organisms will evolve independently of each other and become increasingly different over time in a phenomenon called the 'Meselson effect.' Researchers from the University of Glasgow have demonstrated the Meselson effect for t... Read More

Zika from sex, the byway but not the highway

Can Zika virus be sexually transmitted? Perhaps in very rare cases, but the main mode of transmission is certainly via mosquitoes. That’s why I’ve shamelessly stolen a quote on this topic from Dr. William Schaffner of Vanderbilt University: Mosquito transmission is the highway, whereas sexual tr... Read More

The dual role of GALNT3 during influenza infection

Feeling under the weather? Are you congested, maybe having a hard time breathing, especially at night? Don’t worry – this is your body’s natural response to an infection. Mucus production is generally regarded as antimicrobial – it traps particles like virions before they can infect nearby host ... Read More

Targeting the gut microbiome to fight heart disease

Is the way to treat heart disease through a person's stomach? According to a new study, the answer is yes. Researchers have found that a compound found in red wine, resveratrol, reduces the risk of heart disease by changing the gut microbiome.

Cardiovascular disease remains the leading cause ... Read More

MERS research yields surprising finding

In 2015, an unexpectedly large outbreak of Middle East Respiratory Syndrome coronavirus (MERS-CoV) in South Korea had a disastrous impact on the whole country and highlighted scientists limited knowledge of this virus. Now, new research into this outbreak has revealed some very surprising findin... Read More

Microbiology, Cartoons, and Take Home Lessons!

In this blog post, I describe how I had students create their own cartoon depicting microbiological ideas and concepts that most tickled their fancy. I did this on their final exam, and the students came up with really interesting and entertaining ideas. IT's always interesting to see what stu... Read More

Virus Watch: Zika Edition

Virus Watch is a new weekly video series that explores the amazing world of viruses. This week: the latest research on Zika virus, including finding virus in Brazilian monkeys, dengue antibodies helping Zika virus infection, and brain organoids to study how Zika virus causes microcephaly. Read More

The switch from trivalent to bivalent oral poliovirus vaccine: Will it lead to polio?

In four months, 155 countries will together switch from using trivalent to bivalent oral poliovirus vaccine. Will this change lead to more cases of poliomyelitis? Read More

Getting closer to understanding Zika virus, one genome at a time

Several papers published in Genome Announcements recently describe the sequences of new Zika virus isolates. Scientists have known the genomic sequence of at least one Zika virus isolate since 2007, but continue to publish newly isolated strains. What is the importance of these additional sequen... Read More

A chromosome in every cell: PprA funcitons in chromosome segregation after Deinococcus radiodurans irradiation

Exposure to reactive oxygen species, exposure to ionizing radiation, exposure to UV light – all of these are dangerous because of their potential to alter DNA sequences. Changes in DNA can affect a protein coding sequence, potentially influencing its function, but changes in regulatory regions c... Read More

A new vaccine has developed by Russia

Russian President Vladimir Putin claimed Wednesday his country had developed a vaccine for the Ebola virus which has killed thousands of people in west Africa.

But Putin, who is famed for his talent for headline-grabbing announcements, did not give any name for the vaccine, nor did he say how... Read More
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