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Microbiology

This includes the current issues regarding the microbial technlogy. Read More

TWiP 64 letters

Richard writes:


Good morning, day, evening (depending on your time of day). Esteemed professors!


Firstly my weather report, for Weston super Mare, uk.


It is currently 3 centigrade (feels like 2C), dew point 4C, humidity 78%, there has been 1m... Read More

HIV gets the zinc finger

Because all animal viruses initiate infection by binding to a receptor on the cell surface, this step has long been considered a prime target for antiviral therapy. Unfortunately, drugs that block virus attachment to cells have never shown much promise. Another approach, which is to ablate the r... Read More

Marine Microbiology, Twitter Friends, and Shrunken Coffee Cups

In this blog entry, I discuss how marine microbiology is fascinating to students, as well as the topic leading me (via social media) to other marine microbiologists. One of those marine microbiologists made me a "shrunken coffee cup" (shrunken due to being carried below a kilometer of depth on ... Read More

Prominent Virologist Defends The Chinese Hybrid H5N1-H1N1 Research, Calls It ‘Good Science’

There was much written concerning the research published earlier this month in Science, where researchers from China’s Harbin Veterinary Research Institute reported creating an avian H5N1 (highly pathogenic) and pandemic 2009 H1N1 (easily transmissible) hybrid, that according to them, achieved ... Read More

TWiV 269: Herpesvirus stops a nuclear attack



Hosts: Vincent Racaniello, Dickson Despommier Read More

TWiV 277: My podcast Vinny



Hosts: Glenn Rall, Ann Skalka, and  Read More

The Science Behind Honey’s Eternal Shelf Life

Modern archeologists, excavating ancient Egyptian tombs, have often found something unexpected amongst the tombs’ artifacts: pots of honey, thousands of years old, and yet still preserved. Through millennia, the archeologists discover, the food remains unspoiled, an unmistakable testament to the... Read More

TWiV 276: Ramblers go viral



 Host: Vincent Racaniello


Guests: Sus... Read More

TWiV 265: This year in virology



Hosts: Vincent Racaniello, Alan Dove Read More

How many viruses on Earth?

How many different viruses are there on planet Earth? Twenty years ago Stephen Morse suggested that there were about one million viruses of vertebrates (he arrived at this calculation by assuming ~20 different viruses in each of the 50,000 vertebrates on the planet). The results of a new study s... Read More

TWiP 70: Invasion of the swamp eels



Hosts: Vincent Racaniello and Dickson Despommier Read More

Pandoravirus, bigger and unlike anything seen before

The discovery of the giant Mimivirus and Megavirus amazed virologists (and also many others). Their virions (750 nanometers) and DNA genomes (1,259,000 base pairs) were the biggest ever discovered, shattering the notions that viruses could not be seen with a light microscope, and that viral geno... Read More

TWiM 73 Letters

Mark writes:


Hello Team TWiM,


I’ve followed with interest your coverage of Michael’s research into use of copper to fight hospital infection. Of all the interesting papers covered in 2013, I think the one most actionable is episode 55, The Copper Room. His res... Read More

Reducing antibiotic requests from patients with viral infections

For anyone interested in Antibiotic Awareness Week, a big part of the story is that patients (or their parents) demand antibacterials even for viral infections. And doctors often comply, just to get rid of them (the patients, that is). This high-resolution PDF can be printed out for waiting ro... Read More

Hepatitis B viruses in bats

Hepatitis B virus (HBV, illustrated) is a substantial human pathogen. WHO estimates that there are now 240,000,000 individuals chronically infected with HBV worldwide, of which 25% will die from chronic liver disease or hepatocellular carcinoma. The hepatitis B virus vaccine is highly effective ... Read More

Evidence-based antibiotic usage

New recommendation encourages physicians to prescribe _antibacterials_ instead of antibiotics for bacterial infections. This recommendation is based on compelling evidence that the word "antibiotic" confuses almost everyone, including some doctors. The confusion leads to strong patient demands... Read More

Inefficient influenza H7N9 virus aerosol transmission among ferrets

There have been 131 confirmed human infections with avian influenza H7N9 virus in China, but so far there is little evidence for human to human transmission. Three out of four patients report exposure to animals, ‘mostly chickens‘, suggesting that most of the infections are zoonoses. Whether or ... Read More

Cyanine dyes - Non-sulfonated and Sulfonated cyanines Lumiprobe explains

Sulfonated and non-sulfonated cyanines exhibit very similar fluorescent properties. Non-sulfonated cyanines must be dissolved in organic co-solvent (DMF or DMSO) prior to use, and added to a solution of target molecule in aqueous buffers. Recommended volume of co-solvent should be 10% for Cy3, C... Read More

Fouchier vs the Dutch government on influenza H5N1 research

Readers of this blog will remember the furor sparked by Fouchier’s experiments in 2011 in which he developed an avian influenza H5N1 isolate that could transmit among ferrets by aerosol. When Fouchier was ready to publish the results, the Dutch government required that Fouchier apply for an expo... Read More

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