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1977 H1N1 influenza virus is not relevant to the gain of function debate

The individuals who believe that certain types of gain-of-function experiments should not be done because they are too dangerous (including Lipsitch, Osterholm, Wain-Hobson,) cite the 1977 influenza virus H1N1 strain as an example of a laboratory accident that has led to a global epidemic. A new... Read More

TWiV 369: Camel runny noses and other JNK

Hosts: Vincent RacanielloAlan Dove, and Kathy Spindler


<... Read More

TWiP 106: Trematode stormtroopers in snail wars

The TWiP triumvirate solves the case of the Missionary in Kenya, and review the finding of a soldier caste in flatworms that parasitize snails.


Hosts: Vincent Racaniello Read More

BacterioFiles 247 - Animalcule Acetate Ameliorates Asthma

This episode: Feeding mice high-fiber diets reduces their risk of allergic airway disease, even across generations!


(12.1 MB, 13.2 minutes)


Show notes: 
Read More

TWiV 373: The distinguished virology career of Julius S. Youngner

 


Host: Vincent Racaniello 


Guest: Julius S. Youngner


Vincent... Read More

TWiM 119 Letters

Jeanne writes:


Dear TWiM,
 
With regard to the question about culturing gut microbes from Drosophila:
 
I was lucky enough to take a sabbatical in the lab of Dr. Angela Douglas (http://angeladouglasl... Read More

BacterioFiles 249 - Spores Survive Spaceship Scorching

This episode: Bacterial spores can survive atmospheric entry on an artificial meteorite!


(10.7 MB, 11.25 minutes)


Show notes: 
J... Read More

TWiP 104: La maladie du sommeil

Michael returns to help the TWiP trio solve the case of the Delusional African Expatriate, who then discuss the association of natural and induced antibodies in mice with differential susceptibility to secondary cystic echinococcosis.


Hosts:  Read More

BacterioFiles 248 - Tiny Travelers Transport Toxin Trashers

This episode: Bacteria that swarm around in groups carry other bacteria with them that can be helpful for degrading toxins!


(14.2 MB, 15.5 minutes)


Show notes: 
Read More

Stopping malaria in its tracks

A new drug acts as a roadblock for malaria, curing mice of established infection, according to a study in The Journal of Experimental Medicine. Treatment was not associated with obvious side effects, suggesting that the drug may also be safe and effective in humans. Read More

TWiM #126: I’m not scared of zebrafish and mice and bears (oh my!)

The microbiome of hibernating bears, and zebrafish as a model for bacterial sepsis feature in this animal-centric episode of TWiM hosted by Vincent, Michael, and Michele.


Image: Bright-field (top) and fluorescent (bottom) images of zebrafish embryos infected with E. coli strain F11. E... Read More

TWiP 99 letters

 


Mark writes:


Temperature in Oklahoma is 12 degrees C today and rainy.


My guess is Tunga penetrans which is native to South America. The black point at center of itchy toe lesion is the flea which are legs, spiracles and egg laying aparatus. Fema... Read More

The Wall of Polio, version 3.0

Back in 2013 I built a Wall of Polio in my laboratory – a large stack of six-well cell culture plates that have been used to measure the concentration of polioviruses in various samples by plaque assay. It became a focal point of the lab at which many guests came to have their photographs taken.... Read More

Why do we still use Sabin poliovirus vaccine?

The Sabin infectious, attenuated poliovirus vaccines are known to cause vaccine-associated paralysis in a small number of recipients. In contrast, the Salk inactivated vaccine does not cause poliomyelitis. Why are the Sabin vaccines still used globally? The answer to this question requires a bri... Read More

Zika virus and microcephaly

Three reports have been published that together make a compelling case that Zika virus is causing microcephaly in Brazil. Read More

Permissive vaccines and viral virulence

A permissive vaccine prevents disease in the immunized host, but does not block virus infection. Would a permissive vaccine lead to the emergence of more virulent viruses?

This hypothesis is based on the notion that viruses which kill their hosts too quickly are not efficiently transmitted, a... Read More

TWiV 343: The silence of the turnips

 Hosts: Vincent RacanielloDickson DespommierAlan Dove Read More

TWiP 105: Survival of the fattest

The TWiPanosomes solve the case of the Young Man from Anchorage, and discuss how cestode parasites increase the resistance of brine shrimp to arsenic toxicity.


Hosts: Vincent Racaniello Read More

TWiV 379: A mouse divided

Hosts: Vincent RacanielloDickson DespommierAlan Dove Read More

MdlM116: La importancia de los virus como patógenos emergentes en América Latina

Los virus son considerados por la mayoría como patógenos en todo tipo de entidades biológicas.  Sin embargo la gran mayoría de los virus son inocuos a sus células hospedero.  Nuestro invitado de hoy, el Dr. Paolo Zanotto es investigador y profesor en la Universidad de Sao Paolo, Bra... Read More

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