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B cell depletion benefits ME/CFS patients

Patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) showed clinical improvement after extended treatment with the anti-B-cell monoclonal antibody rituximab. This result suggests that in a subset of patients, ME/CFS might be an autoimmune disease. Read More

BacterioFiles 202 - Controlling Coliform Computers

This episode: Programming bacteria to sense and keep genomic records of environmental inputs!

(15.9 MB, 17.4 minutes)

Show notes: 
Read More

Mining Marine Microbes for New Drugs

This slideshow outlines the work of WHOI scientists Tracy Mincer and Kristen Whalen in the quest to beat antibiotic resistance through bioprospecting in the ocean. Read More

BacterioFiles 227 - Microbe Menaces Meningitis

This episode: Colonizing ourselves with friendly bacteria could drive out more risky ones, such as those that cause meningitis!

(9.8 MB, 10.6 minutes)

Show notes: 
Read More

BacterioFiles 188 - Rat Residents Relieve Resin Roughness

This episode: Gut bacteria in Mojave desert woodrats help them detoxify and eat toxic creosote bushes!

(10 MB, 10.8 minutes)

Show notes: 
News item/ Read More

TWiM 111 Letters

Noah writes:

Dear Dr. Schaechter,

First off, I want to thank you for the effort you and your colleagues have invested in Small Things Considered and the podcast TWIM.  Back when I had a longer commute to work, I listened more religiously than now, wh... Read More

BacterioFiles 190 - Bacteriophages Bust Biofilm Beacons

This episode: Engineered phages can both kill bacteria and disrupt their communications!

(14.8 MB, 16.2 minutes)

Show notes: 
Journal Paper

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Wasps do a gain-of-function experiment in caterpillars

Parasitic wasps inject their eggs into lepidopteran hosts, where they carry out their developmental stages. Along with the eggs, the wasps also deliver viruses carrying genes encoding proteins which inhibit caterpillar immune defenses. Some of these genes are permanently transferred to the lepid... Read More

TWiV 354: The cat in the HAART

Hosts: Vincent RacanielloDickson DespommierAlan Dove Read More

BacterioFiles 209 - Myxococcus Menace Motivates Megastructures

This episode: Microbial predators in soil cause microbial prey to build fortifications!

(8.8 MB, 9.5 minutes)

Show notes: 
Journal Paper

Read More

The Arctic fresh water virome

Although we now understand that viruses are the most abundant organisms on Earth, there are gaps in our knowledge about their distribution in different environments. Results of a new study reveal the diversity and distribution of viruses in Arctic fresh waters. Read More

BacterioFiles 219 - Fungi Facilitate Photosynthetic Fuels

This episode: Fungi can act like sticky nets to help harvest algae for biofuels!

(8.3 MB, 9 minutes)

Show notes: 
News item/ Read More

An Ebolavirus vaccine in Africa

An Ebolavirus vaccine has shown promising results in a clinical trial in Guinea. This vaccine has been in development since 2004 and was made possible by advances in basic virology of the past 40 years. Read More

TWiV 353: STING and the antiviral police

Hosts: Vincent RacanielloDickson DespommierAlan Dove, and  Read More

BacterioFiles 216 - Probiotic Promotes Peanut Permissiveness

This episode: Kate Franz and Matt Woodruff from Audiommunity join me to talk about a clinical trial of peanut immunotherapy with probiotics to treat peanut allergies!

(29 MB, 31.75 minutes)

Show notes: 
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The Wall of Polio, version 3.0

Back in 2013 I built a Wall of Polio in my laboratory ā€“ a large stack of six-well cell culture plates that have been used to measure the concentration of polioviruses in various samples by plaque assay. It became a focal point of the lab at which many guests came to have their photographs taken.... Read More

TWiV 356: Got viruses?

Hosts: Vincent RacanielloDickson DespommierAlan Dove Read More

1977 H1N1 influenza virus is not relevant to the gain of function debate

The individuals who believe that certain types of gain-of-function experiments should not be done because they are too dangerous (including Lipsitch, Osterholm, Wain-Hobson,) cite the 1977 influenza virus H1N1 strain as an example of a laboratory accident that has led to a global epidemic. A new... Read More

Stopping malaria in its tracks

A new drug acts as a roadblock for malaria, curing mice of established infection, according to a study in The Journal of Experimental Medicine. Treatment was not associated with obvious side effects, suggesting that the drug may also be safe and effective in humans. Read More

BacterioFiles 206 - Mollusc Maneuvers Microbe Machines to Macerate Maples

This episode: When digesting wood, shipworms outsource their microbial symbionts from gut to gills!

(9.7 MB, 10.6 minutes)

Show notes: 
Journal Paper<... Read More

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