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Paleovirology—Modern Consequences of Ancient Viruses

Here's an interesting essay published in PLoS Biology by Michael Emerman and Harmit S. Malik on paleovirology, a topic recently discussed by Welkin Johnson, on the Small Things Considered blog.


<... Read More

Bacterial Cells Engineered to Blink in Synch

Fluorescence-tagged Escherichia coli cells can be made to "blink" in unison by means of a constructed network of genes and proteins that coordinates oscillations within the growing cell population, according to Jeff Hasty and colleagues from the University of California, San Diego (UCSD) in La J... Read More

Poliovirus vaccine, SV40, and human cancer

Deep sequencing – which identified a viral contaminant of the rotavirus vaccine Rotarix - could have revealed the presence of simian virus 40 (SV40) in the poliovirus vaccine, had the technique been available in the 1950s. Exposure of over 100 million Americans to SV40, and many more worldwide, ... Read More

Finding Patient Zero

Tracing the origin of an outbreak is a critical clue in curing a disease.  But how can scientists track the beginnings of malaria, a disease that has been around for millions of years? Watch researcher Read More

Paleovirology

Welkin Johnson, Assistant Professor of Microbiology and Molecular Genetics at Harvard Medical School and an Associate Blogger for Small Things Considered, ponders the "fossil record" of viruses:

"As a scientist fascinated with the evolutionary interplay between viruses and their hosts, I admi... Read More

TWiV 77

Wladimir writes:


In regard to your question as to cases of known alteration of host behavior by virus that increases the rate of contact among hosts (Twiv 70), the most dramatic example is given by rabies. This extraordinary virus can convert a neurologically and behaviorally... Read More

TWiV 77: Non-nuclear proliferation

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On episode #77 of the podcast This Week in Virology, Vincent, Alan, and Rich revisit circovirus contamination of Rotarix, then discuss poxvirus-like replication of mimivirus in the cell cytoplasm, a... Read More

Poliovirus vaccine safety

The contamination of the rotavirus vaccine Rotarix with porcine circovirus 1 DNA was revealed by deep sequencing. The same technique was also used to demonstrate that oral poliovirus vaccine does not contain viruses that can cause poliomyelitis. Read More

Did van Leeuwenhoek actually observe yeast cells in 1680?

Nanne Nanninga, Emeritus Professor of Molecular Cytology, Swammerdam Institute for Life Sciences, University of Amsterdam, The Netherlands, authors a guest post on Small Things Considered that questions whether van Leeuwenhoek actually observed yeast cells in 1680.

"It is common knowledge tha... Read More

TWiP 7: Tapeworms are fantastic!

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Vincent and Dickson continue their discourse on tapeworms, covering the fish and dog varieties.


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Malaria presented by Joseph DeRisi Part 3: Drug Development

The third video of a three part lecture by Joseph DeRisi focuses on drug development for Malaria. Read More

Malaria presented by Joseph DeRisi: Part 2 Research

The second video in brief set of three lectures by Joseph DeRisi. Read More

Malaria presented by Joseph DeRisi - Part 1: Malaria: Background and Overview

The first video in brief set of three lectures by Joseph DeRisi gives a very general overview of malaria, the disease and Plasmodium falciparum, the causative agent of the most deadly form. Basic research as well as drug development efforts will also be covered in parts two and three of this ser... Read More

When Swine Flew: A presentation on how social media impacted messaging around H1N1

Andre Blackman (aka @mindofandre on Twitter and author of the Pulse + Signal blog) recently shared a presentation on Slide Share that reviews the CDC and the public health community's innovative use of soc... Read More

MTS47 - Peter Daszak - Stalking the Wild Microbe

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Inhibitors of XMRV

Xenotropic murine leukemia virus related virus (XMRV) has been implicated in prostate cancer and chronic fatigue syndrome (CFS). Because XMRV is a retrovirus, it might be susceptible to antiviral drugs that are licensed for the treatment of AIDS. AZT (azidothymidine) was previously found to bloc... Read More

The most important paper ever in microbiology

Jonathan Eisen (@phylogenomics on Twitter) has a new post on his The Tree of Life blog that looks at why the paper "Phylogenetic structure of the prokaryotic domain: The primary kingdoms" by Carl Woese and George Fox may be the most important paper (see http://www.pnas.org/content/74/11/5088.ful... Read More

Are two tails better than one? A look at the Acidianus two-tailed virus

Merry Youle of Small Things Considered fame has a new post on the site that looks at the Acidianus two-tailed virus.

Snippet:

"Why two tails? Why such long tails? The researchers note that ATV is the only virus of an acidophilic hyperthermophile known to lyse its host, albeit only under st... Read More

Speculation Surrounding Sporulation in the Mycobacteria

Tim Sampson, a graduate student at Emory University in the Microbiology and Molecular Genetics program, looks at two research papers with conflicting conclusions about the presence of endospores in very late stationary phase cultures of Mycobacterium marinum, a common model for acute Mycobacte... Read More

Will the iPad Replace Your Lab Notebook?

The release of the iPad this week may bring the long-expected replacement of the paper-bound lab notebook by electronic notebooks one step closer. But are scientists, particularly PIs, comfortable with electronic lab notebooks?

The rise of the tablets
The concept of an electronic lab noteboo... Read More

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