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Virus Adaptation and Treatment - A paradigm linking herpes- virus immediate-early gene expression apoptosis and myalgic encephalomyelitis chronic fatigue syndrome

Multiple viruses have been linked to ME/CFS suggesting that multiple pathogens cause the same disease or several diseases with core signs and symptoms. Or if you are on Team XMRV /MuLV - a retrovirus could be the mastermind. No matter how you slice it in science, questions beget theories which... Read More

TWiV 189: Five postdocs in Glasgow



Hosts: Vincent Racaniello, Vanessa Cowton, Mary Holton, Mark Robinson, Swetha Vijayakrishnan, and Gavin Wilkie


Vincent returns to t... Read More

Legal opinion: H5N1 research and the limits of government regulation of science

John D. Kraemer, JD, MPH, assistant professor of health systems administration at Georgetown University School of Nursing & Health Studies, and Lawrence O. Gostin, the Linda D. and Timothy J. O’Neill Professor of Global Health Law and faculty director of the O'Neill Institute for National and Gl... Read More

TWiP 17 Letters

Bjorn writes:

Hi Vincent and Dickson,


I want to correct a statement you made in the trypanosomes episode. Apolipoprotein L-I in human blood kills only the subspecies Trypanosoma brucei brucei, whereas the East African subspecies Trypanosoma brucei rhodesiense and the... Read More

The Human Lake

Science writer Carl Zimmer writes a masterful blog piece tracing the history of the study of ecosystems, from lakes to the human microbiome. Just one interesting fact: In their lifetimes, individual humans will produce about five elephants worth of microbes. Read More

NEJM: The Burden of Disease and the Changing Task of Medicine

At first glance, the inaugural 1812 issue of the New England Journal of Medicine and Surgery, and the Collateral Branches of Science seems reassuringly familiar: a review of angina pectoris, articles on infant diarrhea and burns. The apparent similarity to today's Journal, however, obscures a fu... Read More

TWiV 167: It starts with a cough



Hosts: Vincent Racaniello, Dickson Despommier Read More

TWiV 188 Letters

Judi writes:


To our TWIV leaders!


If you have a mac with Apps, please go to the app store and download cell images.... I think you'll have a great time going through them.


One other thing - I listened to your show on science reform with interest but I ... Read More

A viral mashup in snakes

If you know anything about snakes you might be familiar with snake inclusion body disease, or IBD. This transmissible and fatal disease affects snakes of a variety of species but has been best studied in boas. The name comes from the presence of large masses (inclusions) in the cytoplasm of cell... Read More

TWiV 100 Letters

Damon writes:


I've been having an enjoyable time on my commute lately catching up with TWiV. Today I listened to #26 (Poxviruses), which included a discussion of Tysabri and PML. I work at Millipore which sells many products that go into a MAb production train, includ... Read More

Tiny snow-makers

The Judges' Choice for The Scientist magazine's 2011 Labby Multimedia Awards is this cute video on how microbes are essential for snow formation.













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Publication of XMRV papers should not be blocked

The findings by the NIH and FDA that XMRV is associated with chronic fatigue syndrome has been accepted for publication by the Proceedings of the National Academy of Sciences (PNAS). Release of the article has been blocked by PNAS due to work carried out by the US Centers for Disease Control and... Read More

El podcast del Microbio Nº194. Algas para limpiar un desastre (Algae for nuclear clean-up)



























El podcast del Microbio Nº194 is about the recent observation that the algae Closterium moniliferum could remove strontium... Read More

TWiV 177 Letters

John writes:


Dear TWIVvers,


In TWIV 173, you talked about a study on antibody levels to bird flu (H5N1) in various populations, and related this to infections that don't cause serious enough illness to send someone to the hospital, or perhaps to get them teste... Read More

A mad cow in America

A dairy cow in California is the fourth known American case of mad cow disease, which is caused by prions, infectious agents composed only of protein (the story hit the press the day after my lecture on this type of illness). Unlike viruses, prions have no nucleic acid and no protective coat. Bu... Read More

The Rise of Genomic Superspreaders

One hundred million years ago the earth’s climate was much warmer than today and vast inland seas stretched across entire continents. The land was dominated by charismatic megafauna that would one day serve as inspiration for Sir Arthur Conan Doyle’s novel The Lost World. This period is commonly... Read More

TWiV 120 Letters

Ashley writes:


Vincent, I am a huge fan of TWIV and thank you and the others for taking time out of your busy schedule to do the program. I have my B.S. in Biology and Chemistry and would love to go back to school. I read textbooks, listen to podcasts from itunesU and... Read More

TWiV 165 Letters

Justin writes:


Are you, Alan Dove and Prof. Racaniello, saying you think Mikovits and/or others on the Lombardi paper lied about the results or blinding? I think circumspection is a natural human reaction to the allegations of theft that have been made against Dr. Mik... Read More

TWiV 115 Letters

Vinayaka writes:


Some additional info that I gathered on viruses on the verge of elimination (may or may not be new to you):


It appears that the next virus on the list of FAO to eradicate is PPR virus ( Read More

Palese: Don’t censor live-saving science

Renowned influenza virologist Peter Palese has penned an opinion column for the science journal Nature in which he uses his experience in reconstructing the 1918 pandemic influenza virus strain to question the censoring of H5N1 results by the National Science Advisory Board for Biosecurity (NSAB... Read More

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