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Aaron J. Shatkin, 77

Aaron J. Shatkin was well known for his work on reoviruses beginning in the 1960s in his laboratory at the Roche Institute of Molecular Biology in Nutley, NJ and then at Rutgers University. He was among the first to appreciate that virus particles contained many different enzymes, such as RNA po... Read More

TWiV 122 Letters

Luke writes:


Hello TWiV hosts,


I'm currently working as a technician in the biochemistry and molecular biophysics department at Columbia, having just received my BA from here in the Spring. First of all, I'd like to join the chorus of praises ... Read More

New Elsevier Slogan: “It’s All about The Benjamins”

Rich Condit found an article highly critical of the original Wakefield study (claiming a link between MMR vaccine and autism) which was published in the same issue of Lancet. He asked the publisher, Elsevier, to open up the article to non-subscribers so he could recommend it as a pick of the wee... Read More

Are there viruses of arsenic-utilizing bacteria?

A salt-loving (halophilic) bacterium which can grow in medium containing arsenic instead of phosphorus has been selected from the microbial community of Mono Lake in California. Arsenic (As) is a chemical analog of phosphorus and is usually toxic because it can enter metabolic pathways in the pl... Read More

My virology course at Columbia University

The third annual installment of my virology course at Columbia University, Biology W3310, has begun, and all the lectures will be available online. Read More

A new target for hepatitis C virus

When infection with hepatitis C virus goes from acute to chronic, severe liver disease may occur which requires organ transplantation. Nearly 200 million people are chronically infected with HCV, necessitating approaches to preventing and treating infections. No HCV vaccine is available, and cur... Read More

Finding the key to strengthening the immune response to chronic infections

A team of researchers from The Wistar Institute has identified a protein that could serve as a target for reprogramming immune system cells exhausted by exposure to chronic viral infection into more effective "soldiers" against certain viruses like HIV, hepatitis C, and hepatitis B, as well as s... Read More

TWiV 163 Letters

Ronnie writes:


Hello Professor Vincent,


First of all, thank you for your wonderful podcasts! I'm a CFS sufferer and also a student Applied Science so I'm interested in many of the topics discussed for those two reasons and always learning new things.


I... Read More

TWiV 162 Letters

Sarah writes:


Hello to the TWiV crew,


Here are a couple of picks I thought would be good for provoking thought and generating discussion...


While working on a project, I came across some papers attempting to define what "critical thinking" means. I app... Read More

Virophage, the virus eater

A second virophage has been identified. The name does not signify a virus that infects another virus – it means virus eater.
Read More

The Human Lake

Science writer Carl Zimmer writes a masterful blog piece tracing the history of the study of ecosystems, from lakes to the human microbiome. Just one interesting fact: In their lifetimes, individual humans will produce about five elephants worth of microbes. Read More

TWiV 152 Letters

Atila writes:


Dear TWiVers,


I have heard recently that some types of herpes virus may protect us from bacterial infections. This made me remember of myxomavirus, viral oncotherapy and how tumor cells have a compromised immune response. Do you think it is possi... Read More

The Lazarus virus

There is an excellent question in the comments to “Are all virus particles infectious?“: if the particle-to-PFU ratio for a virus stock is 10,000:1, and I infect 1,000,000 cells with 10,000 particles, how many plaques would I expect to observe? Answering this question provides insight into the p... Read More

XMRV and CFS – It’s not the end

Yesterday the Chicago Tribune published my reaction to the four papers on the retrovirus XMRV published this week in the journal Retrovirology. I was quoted as saying ”These four papers are probably the beginning of the end of XMRV and CFS”. I wish to retract this statement and explain my reason... Read More

A bad day for science

The virologists who carried out the contentious experiments on influenza H5N1 transmission in ferrets have agreed to remove certain details from their manuscript, according to ScienceInsider. This is a bad day for virology, and for science in general. The decision by the NSABB sets a precedent f... Read More

TWiV 155 Letters

Kim writes:


To the TWiVerati Intelligencia,


Each week you begin your show with the tagline, "This Week in Virology: The podcast about viruses, the kind that make you sick."


I recognize that viruses have been responsible for some of the biggest epidemic... Read More

Small fragments of viral nucleic acid cross borders in monkey meat

The finding of viral nucleic acid sequences in illegally imported wildlife products has attracted the attention of the New York Times, which published an article entitled From the jungle to J.F.K., viruses cross borders in monkey meat. Read More

Whole genome sequence of Borrelia burgdorferi...

Human Lyme disease is caused by a number of related Borrelia burgdorferi sensu lato species. We report here the complete genome sequence of Borrelia sp. isolate SV1 from Finland. Read More

Genome Wide Manipulation of the Bacterial Chromosome in Vivo

On the Small Things Considered blog, Michael Schmidt, Professor and Vice Chairman of Microbiology and Immunology at the Medical University of South Carolina, reviews a recent paper entitled "Precise Manipulation of Chromosomes in Vivo Enables Genome-Wide Codon Replacement" by Church and colleagu... Read More

The dwindling American science majors

According to the New York Times (Why Science Majors Change Their Minds), the decline in the number of science majors in the United States has come about in part because the subject matter is too difficult. If this explanation is true, then we have not properly prepared these students in grades K... Read More
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