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TWiM #85: Oscillation in the ocean and a Verona integron

Hosts: Vincent RacanielloMichael Schmidt, ... Read More

Experimental Vaccine For Chikungunya Passes First Test

Scientists have taken the first steps to developing a vaccine for chikungunya — an emerging mosquito-borne virus that has infected more than a half million people in the Western Hemisphere this year. About 600 Americans have brought the virus to 43 states.

The study was small. Only 25 people ... Read More

The Discoverability Challenge – How Can We Make Research Data Easier to Find and Use?

Enhancing the discoverability of public health and epidemiology research data is a key to ensuring that it gets more widely used. This was the topic of a recent workshop hosted by the London School of Hygiene and Tropical Medicine, where researchers and data experts explored the findings of a re... Read More

Microbiology: Microbiome science needs a healthy dose of scepticism

Explorations of how the microscopic communities that inhabit the human body might contribute to health or disease have moved from obscure to ubiquitous. Over the past five years, studies have linked our microbial settlers to conditions as diverse as autism, cancer and diabetes.

This excitemen... Read More

Ebola crisis: A doctor's view from Sierra Leone

West Africa's Ebola epidemic, the deadliest on record, presents particular challenges for medical staff. Here, Irish doctor Gabriel Fitzpatrick describes working for Medecins Sans Frontieres (MSF) at the centre of the outbreak in Sierra Leone:

MSF constructed a special Ebola treatment centre ... Read More

Vaccines can cut the spread of meningitis by nearly 40 per cent

Investigators at the University of Southampton have discovered that two new vaccines can prevent the transmission of meningitis bacteria from person to person.

The vaccines do this by reducing ‘carriage’ of the responsible bacteria in the nose and throats of the population.

Meningitis is... Read More

Progress in the fight against harmful fungi

A group of researchers at the Max F. Perutz Laboratories has created one of the three world's largest gene libraries for the Candida glabrata yeast, which is harmful to humans. Molecular analysis of the Candida glabrata fungus mutations led to the discovery of 28 new genes that are partly respon... Read More

Zombie ant fungi manipulate hosts to die on the 'doorstep' of the colony

A parasitic fungus that must kill its ant hosts outside their nest to reproduce and transmit its infection, manipulates its victims to die in the vicinity of the colony, ensuring a constant supply of potential new hosts, according to researchers at Penn State and colleagues at Brazil's Federal U... Read More

Farmers Fight Poisonous Wheat Fungus with Cleaning and Waiting

Dave Wiechert of Nashville, Illinois, does good business most years cleaning seed for farmers in preparation for planting season. But this year, Wiechert is doing big business after harvest: cleaning fungus off wheat so farmers can sell it.

The "head scab" fungus can produce vomitoxin, a chem... Read More

Scientists Finally Catch On to Social Media

In 2011, Emmanuel Nnaemeka Nnadi needed help to sequence some drug-resistant fungal pathogens. A PhD student studying microbiology in Nigeria, he did not have the expertise and equipment he needed. So he turned to ResearchGate, a free social-networking site for academics, and fired off a few e-m... Read More

BacterioFiles 179 - Functionless Phages Feel Fatiguing

 This episode: Defective phages in bacterial genomes can still have burdensome effects! Why do the bacteria keep them around?


(10.4 MB, 11.3 minutes)


Show notes: 
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New discovery: Microbes can create dripstones

According to new research humble, microscopic organisms can create dripstones in caves. This illustrates how biological life can influence the formation of Earth’s geology - and the same may be happening right now on other planets in space.

According to traditional textbooks dripstones are cr... Read More

In Hunt For New Antibiotics, Scientists Look At Bacteria In Insects' Stomachs

Pampering leafcutter ants with fragrant rose petals and fresh oranges may seem an unlikely way to rescue modern medicine, but scientists at a lab in eastern England think it's well worth trying.

As the world cries out for new antibiotics, researchers at the John Innes Center (JIC) in Norwich ... Read More

Wolbachia Genome Reduction, Phage WO, and Reproductive Parasitism

Abstract:

Wolbachia are maternally transmitted endosymbionts that often alter their arthropod hosts’ biology to favor the success of infected females, and they may also serve as a speciation microbe driving reproductive isolation. Two of these host manipulations include killing males outrigh... Read More

Rethinking The Origin of Species: Discover Magazine Features The Speciation Microbiome Project

From Discover: "Scientists have long known of the important roles played by the microbes on and in our bodies — our microbiomes. These little guys outnumber our own cells 10 to 1, and they help regulate everything from the energy we get out of food to the health of our immune systems. Now, scien... Read More

A Tale of Two Strategies

Bacteria are for the most part gregarious organisms, living predominantly in dense communities consisting of multiple strains. In fact, the majority of infectious bacteria occur as multi-layered structures called biofilms, many of which are composed of multiple types of bacteria. As one can imag... Read More

TWiV 298: MV-NIS de myelo

The TWiV gang answers follow-up questions about the Ebola virus outbreak in West Africa, then discuss treatment of  disseminated multiple myeloma with oncolytic measles virus.


Hosts: Vincent Racaniello... Read More

Introducing the Thanatomicrobiome

In a healthy adult human body, most internal organs such as the brain, spleen, liver, and heart are devoid of microorganisms because the immune system keeps them in check. After human host death, however, the immune system falters and microorganisms proliferate throughout the body beginning in ... Read More

Harnessing the Power of Bacteria’s Sophisticated Immune System

Bacteria’s ability to destroy viruses has long puzzled scientists, but researchers at the Johns Hopkins Bloomberg School of Public Health say they now have a clear picture of the bacterial immune system and say its unique shape is likely why bacteria can so quickly recognize and destroy their as... Read More

Treating Cancer With Bacteria Shows Real Promise

n a groundbreaking study, researchers say injecting bacteria into a tumor helped shrink it.

Bacteria are generally considered more foe than friend, but that may change, if results from a pioneering study are confirmed.

Reporting in the journal Science Translational Medicine, scientists led... Read More
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