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MGH team broadens utility of more compact CRISPR-Cas9 by increasing its targeting range

A team of Massachusetts General Hospital (MGH) investigators has shown that a method they developed to improve the usefulness and precision of the most common form of the gene-editing tools CRISPR-Cas9 RNA-guided nucleases can be applied to Cas9 enzymes from other bacterial sources. In a paper r... Read More

Latest technology could help curb repeat Ebola crisis, experts say

Recent developments in surveillance technology could enable a swifter, more effective response to potentially deadly outbreaks of disease, a study has found. Read More

What effect does environmental temperature have on bacterial virulence?

A recent tragic die-off of saiga antelope has scientists puzzled about what could cause such a sudden, drastic, large-scale death. Infectious disease could easily be playing a part, with Pasteurella multocida and Clostridium perfringens both possible candidates found in animal necropsies. The su... Read More

Identifying milk components that promote a healthy infant microbiome

Breast milk provides an inexpensive, nutrient-filled source of food for babies. Because of this, the American Academy of Pediatrics and the WHO recommend new mothers to exclusively breast feed their babies for the first six months of life, and continue up to two years (supplemented with other fo... Read More

Stress wakes up sleeping herpesviruses -- but how?

Hiding their DNA genome inside the nucleus of the infected cells, the herpesviruses establish a lifelong infection in humans. Not well defined stress conditions are known to wake up these parasites from their dormancy - the latent phase - and reactivate the production of new viral progeny, event... Read More

Microbes After Hours: Understanding the Pathogenesis of the Emerging Zika Virus

Dr. Michael Diamond, 2016 Elizabeth O. King Lecturer, has worked for the past two decades investigating how viruses work, with a goal of defining basic principles of pathoge... Read More

Less effective antimalarial therapies can help fight malaria better

Oxford University scientists have found that the more effective way to beat malaria is to use less effective drugs some of the time. Read More

Scientists are Working on Making Drugs More Biodegradable

BOC Sciences-Wild animals were found carrying drug resistance though they are living in areas where few human activities are existing. This finding makes scientists think about how to prevent the situation from deteriorating and protect water from being polluted furtherly. From the previous blog... Read More

Vitamin C can be Helpful in Improving Blood Vessel Constriction

BOC Sciences-Latest study on vitamin C shows that it can play a positive role in improving blood vessel constriction with almost equal effect as walking. In the study, the exercise of a protein which is the main factor of blood vessel constriction was compared with the effect of vitamin C on bl... Read More

Urinary tract infection: How bacteria nestle in

Almost every second woman suffers from a bladder infection at some point in her life. Also men are affected by cystitis, though less frequently. In eighty percent of the cases, it is caused by the intestinal bacterium E. coli. It travels along the urethra to the bladder where it triggers painful... Read More

Jan. 18 Early Registration Deadline Approaching for 2016 DOE JGI Genomics of Energy & Environment Meeting

The 11th Annual Genomics of Energy & Environment Meeting of the U.S. Department of Energy Joint Genome Institute (DOE JGI), a DOE Office of Science User Facility, will take place March 21-24, 2016 in Walnut Creek, Calif. For information on speakers, workshops, and registration, go to http://bit.... Read More

Nonpathogenic viruses transferred during fecal transplants

Fecal transplants are increasingly being used for refractory Clostridium difficile and other gastrointestinal disorders. While fecal donors are screened for various infectious diseases, it is unclear whether viruses can in fact be transmitted during fecal transplants. Now a new study shows that ... Read More

CRISPR/Cas9 used for rapid functional study of cancer-causing genes

In a novel use of the CRISPR/Cas9 system, which can be deployed to switch genes off, researchers from Germany, the UK and Spain have developed a multiplexed screening approach to study and model cancer development in mice. The scientists mutated genes in the adult mouse liver uncovering their ca... Read More

Whole-genome sequencing can help ID hospital outbreaks

Drug-resistant infections are becoming one of the scariest epidemics since the advent of antibiotic discovery. Although microbes like methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Klebsiella pneumoniae, and multidrug-resistant Pseudomonas aeruginosa are responsible for... Read More

Foot and mouth disease virus: a global threat to agriculture

An important and sometimes overlooked issue of infrastructure is food security. American agriculture and related industries represent $1.5 trillion U.S. dollars and 17% of U.S. jobs. These workers provide the meat, eggs, dairy, and produce that many take for granted will end up on grocery shelve... Read More

Vaccine against respiratory syncytial virus shows promise in early trial

Johns Hopkins Bloomberg School of Public Health researchers say a new candidate vaccine against respiratory syncytial virus (RSV) made with a weakened version of the virus shows great promise at fighting the disease, the leading cause of hospitalization for children under the age of one in the U... Read More

TWiP 109: Blame it on Mother

Daniel and Vincent solve the case of the Truck Driver from India, discuss why parasites resistant to an antimalarial drug are not transmitted by mosquitoes, and introduce Paul who presents a new case study.


Hosts:  Read More

TWiV 389: Alphabet hepatitis with Stan Lemon

Host: Vincent Racaniello 


Guest: Stan Lemon


Vinc... Read More

TWiV 390: Building a better mosquito trap

Project Premonition, a Microsoft Research project that uses drones to capture mosquitoes and analyze them for pathogens, preprint servers, and three mouse models for Zika virus induced birth defects are the topics of this episode hosted by the TWiumvirate and theirs guests Etha... Read More

Tug of war among bacteria

At the University of Cologne, biophysicists in the lab of Professor Berenike Maier were now able to show how differential mechanical forces can lead to cell sorting in biofilms, thereby determining their architecture. In their publication in the journal eLife, the team headed by the biophysicist... Read More
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