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Tool to edit DNA revolutionizing research in Boston area

It is a fascinating quirk of nature: Simple bacteria have an immune system with a memory, which allows them to destroy invading viruses they have encountered in the past.

The phenomenon is more than just a scientific curiosity. In just two years, scientists have discovered how to repurpose th... Read More

Getting a Knit Bacteriophage From a Former Student!

A former student dropped by my lab this morning, and brought me a gift: a knit bacteriophage! Many times, as educators, we hear what we haven't done well, or could do better. Sometimes, like today, we get a priceless "thank you" from a former student. Read More

TWiV 332: Vanderbilt virology

Host: Vincent Racaniello


Guests: Seth BordensteinJames Crowe... Read More

A possible alternative to antibiotics

Scientists from the University of Bern have developed a novel substance for the treatment of severe bacterial infections without antibiotics, which would prevent the development of antibiotic resistance.

Ever since the development of penicillin almost 90 years ago, antibiotics have remained t... Read More

Nicely Aged

Resurrecting ancient beers and wines is a subtle alchemy, but Patrick McGovern knows all the tricks. He directs the Biomolecular Archaeology Project for Cuisine, Fermented Beverages, and Health at the University of Pennsylvania Museum. Many of his ancient brews are sold by Dogfish Head brewery i... Read More

Potentially fatal parechovirus afflicting babies prompts urgent Queensland probe

A little-known virus that can be fatal in young babies has prompted Queensland scientists to undertake urgent medical research.

Parechovirus was first reported in Australia in December last year and there have now been dozens of cases across the country.

There have been 11 confirmed cases ... Read More

Positive clinical results indicate vaccine candidate is highly efficacious against bacterial diarrhea

New results from a safety and immunogenicity study, which included a challenge phase to test efficacy, indicate that a live attenuated enterotoxigenic Escherichia coli (ETEC) vaccine candidate, given in combination with a novel adjuvant, provided significant protection against disease. This repr... Read More

Video Microscope Reveals Movement in "Stock-Still" Objects

The first microscopes, in the 1500s and 1600s, transformed glass panes that looked completely transparent into a universe teeming with bacteria, cells, pollen and intricate crystals. These visionary aids were the first devices to show people that there were cells within a drop of blood. Since th... Read More

TWiV 317: Brazil goes viral

On his second trip to Brazil, Vincent joins Eurico to speak with four young virologists, Gustavo, Cintia, Tatiana, and Suellen, about their work and their prospects for careers in science.


Host:  Read More

Sweet Sweet Straw

The calorie free sweetener erythritol is widely used in Asia; it is also gaining popularity in Europe and America. At the Vienna University of Technology, a new cheap method has been developed to produce erythritol from straw with the help of mould fungi.

Erythritol has many great advantages:... Read More

TWiV 328: Lariat tricks in 3D

Hosts: Vincent RacanielloDickson DespommierAlan Dove Read More

Common Parasite Could Manipulate Our Behavior

Look what the cat dragged in! The parasite Toxoplasma gondii, a common protozoan transmitted by cats, can effect mammalian brain cells in strange ways. In rodents, the parasite has been shown to inhibit fear and actually attract them to the smell of cat urine. Humans can be infected through c... Read More

Cholera Bacteria Spear Their Prey to Grab Genes

The bacteria that cause cholera grab genes from other organisms in a particularly predatory and precise way, new research finds: They spear neighboring cells with a kind of poison-tipped spike.

Bacteria often grab genes from other organisms and incorporate that DNA into their own genomes. But... Read More

TWiM 100 Letters

Matt Daugherty writes:


I just listened to the latest TWiM. Thanks for covering our horizontal gene transfer paper! It was great to hear you all talk about it and give your thoughts.


With regards to the selective pressure for retention of the Dae’s in genomes o... Read More

Yogurt bacteria could replace colonoscopies for cancer detection

Let's face it: colonoscopies are pretty unpleasant. But what if you could eat a spoonful of yogurt to check for cancer rather than enduring that procedure? MIT professor Sangeeta Bhatia is working on engineered bacteria that detects colorectal cancer. Read More

How a bacterial cell recognizes its own DNA

It may come as a bit of a surprise to learn that bacteria have an immune system - in their case to fight off invasive viruses called phages. And like any immune system - from single-celled to human - the first challenge of the bacterial immune system is to detect the difference between "foreign"... Read More

Scientists find way to trap, kill malaria parasite

Scientists may be able to entomb the malaria parasite in a prison of its own making, researchers report. As it invades a red blood cell, the malaria parasite takes part of the host cell's membrane to build a protective compartment. The parasite then starts a series of major renovations that tran... Read More

Thames study: rivers can be a source antibiotic resistance

Rivers and streams could be a major source of antibiotic resistance in the environment.

The discovery comes following a study on the Thames river by scientists at the University of Warwick’s School of Life Sciences and the University of Exeter Medical School.

The study found that greater n... Read More

TWiP 89: Day TWiPers

Vincent, Dickson, and Daniel reveal last week's case study and introduce a new one concerning a patient who traveled to Belize.


Hosts: Vincent Racaniello,&... Read More

Bacteria are as individual as people.

Bacteria are as individual as people, according to new research by Professor Peter Young and his team in the Department of Biology at the University of York. Bacteria are essential to health, agriculture and the environment, and new research tools are starting to shed more light on them.

The ... Read More
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