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Scripps research-designed drug candidate significantly reduces HIV reactivation rate

HIV-infected patients remain on antiretroviral therapy for life because the virus survives over the long-term in infected dormant cells. Interruption of current types of antiretroviral therapy results in a rebound of the virus and clinical progression to AIDS. Read More

BacterioFiles 206 - Mollusc Maneuvers Microbe Machines to Macerate Maples

This episode: When digesting wood, shipworms outsource their microbial symbionts from gut to gills!

(9.7 MB, 10.6 minutes)

Show notes: 
Journal Paper<... Read More

HIV uses the immune system's own tools to suppress it

A Canadian research team at the IRCM in Montreal, led by molecular virologist Eric A. Cohen, PhD, made a significant discovery on how HIV escapes the body's antiviral responses. The team uncovered how an HIV viral protein known as Vpu tricks the immune system by using its own regulatory process ... Read More

Study identifies new way to kill the malaria parasite

Scientists have discovered new ways in which the malaria parasite survives in the blood stream of its victims, a discovery that could pave the way to new treatments for the disease.

The researchers at the Medical Research Council's (MRC) Toxicology Unit based at the University of Leicester an... Read More

Virus-like particle vaccine protects mice from many flu strains

A vaccine that protects against a wide variety of influenza viruses (a so-called universal flu vaccine) is a critical public health goal given the significant rates of illness and death caused by seasonal influenza and the potentially devastating effects of a pandemic influenza strain. Now, rese... Read More

Single dose Ebola vaccine is safe and effective in monkeys against outbreak strain

National Institutes of Health (NIH) scientists report that a single dose of an experimental Ebola virus (EBOV) vaccine completely protects cynomolgus macaques against the current EBOV outbreak strain, EBOV-Makona, when given at least seven days before exposure, and partially protects them if giv... Read More

Expression of a single gene lets scientists easily grow hepatitis C virus in the lab

Worldwide, 185 million people have chronic hepatitis C. Since the late 1980s, when scientists discovered the virus that causes the infection, they have struggled to find ways to grow it in human cells in the lab -- an essential part of learning how the virus works and developing new effective tr... Read More

Evolutionary war between microorganisms affecting human health, IU biologist says

BLOOMINGTON, Ind. -- Health experts have warned for years that the overuse of antibiotics is creating "superbugs" able to resist drugs treating infection. Read More

Researchers develop world's most sensitive test to detect infectious disease, superbugs

Infectious diseases such as hepatitis C and some of the world's deadliest superbugs--C. difficile and MRSA among them--could soon be detected much earlier by a unique diagnostic test, designed to easily and quickly identify dangerous pathogens. Read More

BacterioFiles 212 - Ghosts Get Good Guarding

This episode: Bacterial ghosts could make good vaccines for different things!

(9.8 MB, 10.7 minutes)

Show notes: 
Journal Paper

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To better understand the importance of gut bacteria in human health, researchers measured the time it takes food to move through the gastrointestinal tract, called gut motility, in mice—in a way that mimics the dietary effects of world travel. Read More

Virus in cattle linked to human breast cancer

BERKELEY -- A new study by University of California, Berkeley, researchers establishes for the first time a link between infection with the bovine leukemia virus and human breast cancer. Read More

Crime-scene compound may be newest tool in fight against malaria

The compound that detectives spray at crime scenes to find trace amounts of blood may be used one day to kill the malaria parasite. Read More

Breastfeeding May Bring Children with More Risk for Toxic Chemicals

BOC Sciences-It has been long considered that breastfeeding would much better than formula milk in various aspects like the variety of nutrition and etc. However recent research found that breastfeeding may expose children to a series of industrial chemical substances that can pose harm to the i... Read More

TWiV 356: Got viruses?

Hosts: Vincent RacanielloDickson DespommierAlan Dove Read More

Why West Nile virus is more dangerous in the elderly

West Nile virus (WNV) is particularly dangerous in older people, who account for a large number of severe cases and deaths caused by the virus. WNV infection turns serious when the virus crosses the blood-brain-barrier and wreaks havoc among nerve cells in the brain. A study published on July 23... Read More

A Compound from Beet Juice is Beneficial to Heart Failure Treatment

BOC Sciences-Scientists team from Washington University inspired by their previous study on beet juice that athlete drink for better muscle performance, and found nitrate existing in the juice can be helpful in the treatment of heart failure. Read More

The sting in dengue's tail

In a new Science study, Duke-NUS Graduate Medical School Singapore (Duke-NUS) scientists have identified how small changes in dengue's viral genome can affect the virus' ability to manipulate human immune defences and spread more efficiently. This research is the first of its kind that examined ... Read More

Why do we still use Sabin poliovirus vaccine?

The Sabin infectious, attenuated poliovirus vaccines are known to cause vaccine-associated paralysis in a small number of recipients. In contrast, the Salk inactivated vaccine does not cause poliomyelitis. Why are the Sabin vaccines still used globally? The answer to this question requires a bri... Read More

Romidepsin can reverse HIV latency in patients on long-term ART

A cure for HIV requires the eradication of latent (i.e., dormant and therefore hidden) virus from reservoirs in immune cells throughout the body. HIV latency depends on the activity of proteins from the human host called histone deacetylases (HDAC), and previous work has shown that HDAC inhibito... Read More
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