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Getting Started with MicrobeWorld

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TWiV 387: Quaxxed

Hosts: Vincent RacanielloDickson DespommierAlan Dove, and  Read More

TWiM 125 Letters

Inspired by William:


Dear TWiMers;
Greetings from Berkeley where miracle March (water-wise) was perhaps half a miracle, but that is definitely better than none. At least we will not run out of water this summer.


I found this quasi-synthetic biology result... Read More

Researchers Find Novel Signature in the Brains of Children with Cerebral Malaria: Disease exacerbated by HIV

Washington, DC - September 22, 2015 - Cells associated with inflammation and blood clotting accumulate in the brain blood vessels of children affected by a potentially fatal form of malaria called cerebral malaria (CM), potentially contributing to the disease process, an international team of re... Read More

TWiV 378: Herpes plays DUBstep

Hosts: Vincent RacanielloDickson DespommierAlan Dove, and  Read More

HIV particles do not cause AIDS, our own immune cells do

Researchers from the Gladstone Institutes have revealed that HIV does not cause AIDS by the virus's direct effect on the host's immune cells, but rather through the cells' lethal influence on one another. Read More

Predicting UTI antibiotic resistance

By now, the news of a colistin-resistant E. coli isolate from a patient in the United States is widespread, with many major news sources covering the story. Most outlets highlighted the ease of future transfer of the plamid-borne mcr-1 gene between bacteria, the role of agricultural antibiotic u... Read More

TWiM 127 Letters

Stefan writes:


Just discovered this nice episode.
Well made and nicely discussed comment on our pack-hunting paper; quick reply to the question what would happen if you add one single amoebae: it would multiply and a clonal pack would do the same thing as observe... Read More

Why do we still use Sabin poliovirus vaccine?

The Sabin infectious, attenuated poliovirus vaccines are known to cause vaccine-associated paralysis in a small number of recipients. In contrast, the Salk inactivated vaccine does not cause poliomyelitis. Why are the Sabin vaccines still used globally? The answer to this question requires a bri... Read More

Bacteria in ancient flea may be ancestor of the Black Death

CORVALLIS, Ore. - About 20 million years ago a single flea became entombed in amber with tiny bacteria attached to it, providing what researchers believe may be the oldest evidence on Earth of a dreaded and historic killer - an ancient strain of the bubonic plague. Read More

Romidepsin can reverse HIV latency in patients on long-term ART

A cure for HIV requires the eradication of latent (i.e., dormant and therefore hidden) virus from reservoirs in immune cells throughout the body. HIV latency depends on the activity of proteins from the human host called histone deacetylases (HDAC), and previous work has shown that HDAC inhibito... Read More

Study points to a possible new pathway toward a vaccine against MRSA

New research led by NYU Langone Medical Center has uncovered why a particular strain of Staphylococcus aureus -- known as HA-MRSA -- becomes more deadly than other variations. These new findings open up possible new pathways to vaccine development against this bacterium, which the Centers for Di... Read More

Zika virus has potential to spread rapidly through Americas

The Zika virus, possibly linked to serious birth defects in Brazil, has the potential to spread within the Americas, including parts of the United States, according to an international team of researchers who track the spread of infectious diseases. Read More

TWiV 391: Whiter reefs, fresh breath

If you have always wanted to know what coral reefs and the human oral cavity have in common, listen as guests David Pride and Forest Rohwer talk about their work on the microbiomes and viromes of these two environments, and you'll also understand why mucus is cool.


Hosts:  Read More

UV light robots cut c. diff transmissions by 25 percent on cancer patient floors

SAN DIEGO--Robots are capable of all sorts of tasks to help better treat cancer: They connect oncologists to patients remotely, make incisions, staple them shut, deliver "nano" therapies--and they clean rooms. New research from Penn Medicine infection control specialists found that ultraviolet (... Read More

Dually noted: New CRISPR-Cas9 strategy edits genes 2 ways

The CRISPR-Cas9 system has been in the limelight mainly as a revolutionary genome engineering tool used to modify specific gene sequences within the vast sea of an organism's DNA. Cas9, a naturally occurring protein in the immune system of certain bacteria, acts like a pair of molecular scissors... Read More

Intestinal worms 'talk' to gut bacteria to boost immune system

EPFL researchers have discovered how intestinal worm infections cross-talk with gut bacteria to help the immune system. Read More

The American Society for Microbiology Designates the University of Illinois at Urbana-Champaign as a “Milestones in Microbiology” Site

Washington, DC –October 8, 2015 – The University of Illinois at Urbana-Champaign has been named a Milestones in Microbiology site by the American Society for Microbiology (ASM). A dedication ceremony is scheduled for Friday, October 16, 2015, at 3 pm at the Charles Miller Auditorium, B102 Chemi... Read More

Portraits of Microbiologists Using Luminous Bacteria as "Paint."

My wife Jennifer Quinn​ hits it out the park: a portrait of Kenneth Nealson​ and the late Woody Hastings "painted" with luminous bacteria, giving them props for the early days of quorum sensing---where the basic principles were first uncovered in bioluminescent microbes. This principle of "aut... Read More

The superbug that doctors have been dreading just reached the U.S

For the first time, researchers have found a person in the United States carrying bacteria resistant to antibiotics of last resort, an alarming development that the top U.S. public health official says could signal "the end of the road" for antibiotics.

The antibiotic-resistant strain was fou... Read More

TWiM 131: Mice behaving badly

Michael and Vincent present Spotlights, brief reviews of classic papers in the Journal of Bacteriology, and explain how a single bacterial species can reverse autism-like social deficits in the offspring of obese mice.


Hosts: Vinc... Read More

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