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'Ensemble' modeling could lead to better flu forecasts, study finds

By combining data from a variety of non-traditional sources, a research team led by computational epidemiologists at Boston Children's Hospital has developed predictive models of flu-like activity that provide robust real-time estimates (aka "now-casts") of flu activity and accurate forecasts of... Read More

TWiV 393: Lovers and livers

The TWiVerati revisit possible sexual transmission of Zika virus, and reveal how a cell protein that allows hepatitis C virus replication in cell culture enhances vitamin E mediated protection against lipid peroxidation.

Hosts:  Read More

TWiM 133 Letters

Arthur writes:

Hello TWIMers!

I'm a graduate student working in mycoplasmology and I  must say I've been overjoyed to hear the past few episodes mention our tiny friends!

Elio's mention of their unique mechanism of moving ("Gliding Motility") made... Read More

Insecticide-treated nets may still prevent malaria despite mosquito resistance

Insecticide-treated nets may still help prevent malaria despite mosquitoes developing resistance, according to a new study published in Parasites & Vectors. Read More

Register now for FREE Microbes and the Miracle of Compost Tea webinar on Jan. 14

Click the above "source" link to register: http://cires.colorado.edu/education-outreach/events/test-event/?eID=409

Join us to learn how and why microbes are the natural secret to a healthy soil environment in growing lush lawns and abundant gardens. The science behind soil microbes and tips o... Read More

Social yeast cells prefer to work with close relatives to make our beer, bread and wine

Baker's yeast cells living together in communities help feed each other, but leave incomers from the same species to die from starvation, according to new research from the University of Cambridge. Read More

BacterioFiles 262 - Pathogen Polyketide Protects and Punishes

This episode: Clostridium bacteria that infect potatoes can both kill competitors and tolerate oxygen, thanks to the pink compounds they produce!

(12.4 MB, 13.5 minutes)

Show notes: 
Journal Paper:

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TWiM 129 Letters

Steven writes:

Dear Vincent et al,

Firstly, congratulations for keeping up such a wide range of thought provoking podcasts, and maintaining such a tremendous output. I find they all leave me with more questions than answers, which is, I think, a sign of good s... Read More

TWiP 112: A NOD to a tricky helminth

The TWiP trio solve the case of the Woman from Washington Heights, and reveal how helminth infection protects mice deficient in the Crohn's disease gene NOD2 from intestinal disease by inhibiting colonization with an inflammatory bacterial species.

Hosts:  Read More

A biofilm model that accounts for cell aggregates

Whether you’ve Google-searched “biofilm” to learn more yourself, taken courses covering the subject, or are deeply embedded in biofilm-related research, you’ve probably encountered a model similar to the one below, which represents biofilm maturation. In the current model, a biofilm begins with ... Read More


A gene that lets bacteria resist polymyxins—the last line of antibiotic defense we have left—has shown up in widespread bacteria samples from pigs and patients in south China, including strains with epidemic potential. Read More

New SARS-like virus can jump directly from bats to humans, no treatment available

Researchers from the University of North Carolina at Chapel Hill have discovered a new bat SARS-like virus that can jump directly from its bat hosts to humans without mutation. However, researchers point out that if the SARS-like virus did jump, it is still unclear whether it could spread from h... Read More

Yet another reason to avoid methamphetamine: negative effects of meth on wound healing

Dr. Luis Martinez was on a dream vacation with his three boys. Far from their native New York home, they were traveling along the California coast with the ultimate stop at Disneyland. Unfamiliar with the roads, Martinez took a wrong turn outside of Fresno and found himself in a less pleasant pa... Read More

Studies raise questions about impact of statins on flu vaccination in seniors

A new pair of studies suggests that statins, drugs widely used to reduce cholesterol, may have a detrimental effect on the immune response to influenza vaccine and the vaccine's effectiveness at preventing serious illness in older adults. Published in The Journal of Infectious Diseases, the find... Read More

NIH-sponsored clinical trial of chikungunya vaccine opens

An experimental vaccine to protect against the mosquito-borne illness chikungunya is being tested in a Phase 2 trial sponsored by the National Institutes of Health. Results from an initial trial of the vaccine, which was developed by scientists at the NIH National Institute of Allergy and Infect... Read More

Microbial communication over the airwaves

Jean-Paul Latgé originally wanted to know if he could test the breath of patients with Aspergillus infections for volatile compounds produced by the fungus. His group at the Pasteur Institute in Paris thought this might be a new way of diagnosing fungal culprits like Aspergillus fumigatus that o... Read More

Asymptomatic people can transmit Dengue viruses to Mosquitos

75% of the ~390 million people infected with dengue viruses present with no symptoms (asymptomatic). It is generally assumed that these asymptomatic infections cannot be transmitted to mosquitos. Not only does this study show that people with asymptomatic infections transmitted the virus to mo... Read More

TWiM #134: Lipids that live forever

Design of a synchronously lysing bacterium for delivery of anti-tumor molecules in mice, and hopanoids, the lipids that live forever, brought to you by the four Microbies of TWiM.

Hosts: Vincent Racaniello, Elio Schaechter,... Read More

Study finds that Ebola vaccine is safe and stimulates strong immune response

Baltimore, MD, November 17, 2015--A clinical trial of a new Ebola vaccine (ChAd3-EBO-Z) that resulted from an unprecedented global consortium assembled at the behest of the World Health Organization has found that it is well tolerated and stimulates strong immune responses in adults in Mali, Wes... Read More

TWiV 401: Vector victorious

Zika virus spreads in the USA, a Zika virus DNA vaccine goes into phase I trials, and how mosquito bites enhance virus replication and disease, from the friendly TWiFolk Vincent, Dickson, Alan, and Kathy.

Hosts:  Read More

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