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Ebola Outbreak 2014 2015 by Dr. Fauci

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Too exhausted to fight -- and to do harm

An 'exhausted' army of immune cells may not be able to fight off infection, but if its soldiers fight too hard they risk damaging the very body they are meant to be protecting, suggests new research from the University of Cambridge. Read More

TWiP 79 letters


Jesse writes:


Doctors TWiP,


I came across this paper and thought it sounded interesting for a discussion on TWiP:


Colonisation resistance in the sand fly gut: Leishmania protects Lutzomyia longipalpis from bacterial infection
Read More

TWiV 312: She sells B cells

The TWiVbolans discuss the finding that human noroviruses, major causes of gastroenteritis, can for the first time be propagated in B cell cultures, with the help of enteric bacteria.


Hosts:  Read More

Breakthrough antibacterial approach could resolve serious skin infections

Like a protective tent over a colony of harmful bacteria, biofilms make the treatment of skin infections especially difficult. Microorganisms protected in a biofilm pose a significant health risk due to their antibiotic resistance and recalcitrance to treatment, and biofilm-protected bacteria ac... Read More

TWiV 299: Rocky Mountain virology

Vincent visits the Rocky Mountain Laboratories in Hamilton, Montana and speaks with Marshall, Sonja, and Byron about their work on tick-born flaviviruses, innate immunity, and prion diseases.


Host: Vincent ... Read More

Scientists discover bacteria that survives solely by eating electricity

Researchers at Harvard and Yale have used some extreme gene-manipulation tools to engineer safety features into designer organisms.

This work goes far beyond traditional genetic engineering, which involves moving a gene from one organism to another. In this case, they're actually rewriting th... Read More

TWiV 314: Einstein goes viral

Vincent travels to Albert Einstein College of Medicine where he speaks with Kartik, Ganjam, and Margaret about their work on Ebolavirus entry, a tumor suppressor that binds the HIV-1 integrase, and the entry of togaviruses and flaviviruses into cells.


Host:  Read More

BacterioFiles 216 - Probiotic Promotes Peanut Permissiveness

This episode: Kate Franz and Matt Woodruff from Audiommunity join me to talk about a clinical trial of peanut immunotherapy with probiotics to treat peanut allergies!


(29 MB, 31.75 minutes)


Show notes: 
Read More

Smartphone adapted for use as a video microscope to detect parasites in blood in under resourced communities

This is a good news story all around. UC Berkeley engineers, Michael D'Amrosio and Matthew Bakalar (UC Berkeley Bioengineering) with medical personal from NIAID, Dr. Thomas Nutaman and his collaborators from Cameroon and France collectively took the omni-present global resource, a standard smar... Read More

TWiV 319: Breaking breakbone

The TWiVers review the outcomes of two recent phase 3 clinical trials of a quadrivalent dengue virus vaccine in Asia and Latin America.


Hosts: Vincent Racaniello Read More

Cigarette smoke makes superbugs more aggressive

Methicillin-resistant Staphylococcus aureus (MRSA), an antibiotic-resistant superbug, can cause life-threatening skin, bloodstream and surgical site infections or pneumonia. Researchers at the University of California, San Diego School of Medicine now report that cigarette smoke may make matters... Read More

TWiV 321: aTRIP and a pause

Paul Duprex joins the TWiV team to discuss the current moratorium on viral research to alter transmission, range and resistance, infectivity and immunity, and pathogenesis.


Hosts: Vincent Racaniel... Read More

TWiV 326: Giving HIV a flat tyr

Hosts: Vincent RacanielloAlan Dove, and  Read More

TWiM 97 Letters


Dennis writes:
hi Doc,


A paper just published in nature:


http://www.nature.com/nature/journal/vaop/ncurrent/pdf/nature14098.pdf


reports an effective antibiot... Read More

The Ebola Outbreak: 'A Dress Rehearsal For The Next Big One'

Until this year, the world had recorded 1,640 deaths from Ebola since the virus was discovered in 1976.

Then Ebola appeared in West Africa.

So far this year, 887 people have died of Ebola in West Africa, the World Health Organization said Monday.

To put that into perspective, more than ... Read More

TWiP 82 letters


Allan writes:


Dear Vincent, Dickson and Daniel,


I like your idea of a TWIP coffee mug prize (or maybe a mug discount).


In this second case study you presented, the present symptoms are pretty vague, but his history is interesting. Also since with ... Read More

TWiV 309: Ebola email

The TWiVocytes answer questions about Ebola virus, including mode of transmission, quarantine, incubation period, immunity, and much more.


 Hosts: Vincent Racaniello Read More

Continuing Discussion on Gain of Function

Should scientific journals publish gain-of-function (GOF) studies, especially those involving pathogens with pandemic potential? While journal editors at the American Society for Microbiology have done so after careful consideration, some scientists expressed concern over that decision. A series... Read More

Have a Happy Bioluminescent Fourth of July!

In this post from my Microbiology/Education blog, I wish everyone a lovely day of food, fellowship, and fireworks. My laboratory brings you our own "fireworks" through bioluminescence! Read More
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