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A role for siderophores in Klebsiella pneumoniae pathogenesis

Despite increasing awareness of Klebsiella pneumoniae as a public health risk, there has been relatively little understood about its mechanisms of pathogenesis.

The bacterium, estimated to be the third most common cause of hospital-acquired infections in the United States in a recent study, c... Read More

TWiM 146 Letters

Jonathan writes:


Hello TWiM Team,


I'm sure it's a long shot but here's hoping for #12!


I was catching up on a SciFri podcast recently and came across this story and just had to share it with you all. (Dr. Racaniello, I think Dixon would also appreciate this but I'll le... Read More

BacterioFiles 278 - Fungal Family Friends and Foes

This episode: Some fungi change from making plants sick to being helpful to plants! How do plants react to them?


(8.1 MB, 8.8 minutes)


Show notes: 


Read More

TWiM 142 Letters

Carole writes:


Dear Vincent and hosts of TWIM,


I am a long time listener and fan of your weekly TWIM podcasts. I really enjoyed the latest episode in which you discussed a paper by Kelly Wrighton and colleagues, and was especially... Read More

TWiV 435: Two virus particles walk into a cell

The TWiVome discuss the blood virome of 8,420 humans, and thoroughly geek out on a paper about the number of parental viruses in a plaque.


Hosts: Vincent Racaniello Read More

Diverse fungi inhabit chronic wounds and inhibit healing

Gruesome, ghastly, grisly. These are the words that popped into my head when I googled images of diabetic foot ulcers—one of the most common chronic wounds creating a silent and costly epidemic in healthcare.

Perhaps even more shocking is the mortality rate connected to these open wounds, wh... Read More

BacterioFiles 281 - Prokaryote Partners Produce Plastic

This episode: Microbes with complementary abilities help each other grow and produce useful stuff from the air!


(12 MB, 13.2 minutes)


Show notes: 


Journal Paper:

Smith MJ, Francis MB. 2016. Read More

TWiV 431: Niemann-Pick of the weak

The TWiVirions reveal bacteriophage genes that control eukaryotic reproduction, and the biochemical basis for increased Ebolavirus glycoprotein activity during the recent outbreak.


Hosts:  Read More

TWiV 411: Chicken runs

The TWiVeroos examine a reverse spillover of Newcastle disease virus vaccines into wild birds, and identification of a protein cell receptor for murine noroviruses.


Hosts: Vincent Racaniel... Read More

BacterioFiles 271 - Dictyostelium Delivers DNA Deathtraps

This episode: Slime molds have special cells that capture and kill bacteria using traps made of DNA!


(11.2 MB, 12.25 minutes)


Show notes: 



Read More

One antibody to neutralize them all: a human IgG1 is effective against multiple subtypes of influenza A virus

The changing weather reminds us that influenza season is around the corner, which means it’s nearly time to get your annual vaccine. This year’s vaccine is updated to protect against influenza A viruses H1N1 + H3N2 and influenza B virus Victoria lineage. These strains are included in vaccine pro... Read More

TWiV 426: I'm Axl, and I'll be your cervid today

The sages of TWiV explain how chronic wasting disease of cervids could be caused by spontaneous misfolding of prion protein, and the role of the membrane protein Axl in Zika virus entry into cells.


Hosts:  Read More

Polio in Nigeria

Polio returns to Nigeria after two years - but it turns out it had never gone away.
Read More

TWiV 418: Of mice and MERS

The TWiVsters describe a new animal model for MERS coronavirus-induced acute respiratory distress syndrome, produced by CRISPR/Cas9 editing of the mouse gene encoding an ortholog of the virus receptor.


Hosts:  Read More

Fungus causing fatal infections in hospitalized patients has unique growth patterns

One of the important tasks of Public Health England’s Mycology Reference Laboratory is to identify any newly emerging fungal pathogens that could become a public health risk. In recent months, the lab had tracked several clusters of Candida auris infections in British hospitals. The multidrug-re... Read More

Vincent Racaniello: Earth’s Virology Professor

A new blog written by undergraduate students from the School of Genetics and Microbiology, Trinity College Dublin features Vincent Racaniello, PhD, host of This Week in Virology.

"Most students studying science at university will inevitably become familiar with the names and works of a wide r... Read More

How does antimicrobial resistance spread?


How does antibiotic resistance spread?

Antibiotic resistance is the ability of bacteria to combat the action of one or more antibiotics.
Humans and animals do not become resistant to antibiotic treatments, but bacteria carried by humans and animals can.

In animal farming

Animals may ... Read More

Close Quarters: The Importance of Interspecies Interactions in Microbial Biofilms

Biofilms, surface-attached microbial communities encased in an extracellular matrix, are one of the most common macroscopic microbial structures we can see in nature. Biofilms like those seen in pond scum, in dental plaque, or in hot springs, are mixed communities with the members forming both a... Read More

Improving the quality of dairy products

Bitter tasting yogurt or cheese may not make it to your refrigerator, but it is produced and the result of pesky bacteria. The microbial composition of raw milk impacts the quality, shelf life, and safety of processed milk and other dairy products. Controlling the quality of these products is tr... Read More

TWiM #143: E-scaffolds and receptor transfer

Vincent, Michael, and Michele explain the use of an electrochemical gradient to eliminate bacterial biofilms, and how phage susceptibility can be transferred by exchange of receptor proteins.


Hosts: Vincent... Read More

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