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Drug-Resistant Malaria Spreads Across Southeast Asia

Back in 2008, doctors in Cambodia made a worrisome discovery. They were having a hard time curing some people of malaria.

Even the most powerful drug wasn't clearing out the parasite from patients' blood as quickly as it should. Malaria had evolved resistance to the last medicine we have agai... Read More

Elusive viral 'machine' architecture finally rendered

Biologists have worked with the Lambda virus as a model system for more than 50 years but they've never had an overarching picture of the molecular machines that allow it to insert or remove DNA from the cells that it infects. Now they can, thanks to an advance that highlights the intriguingly i... Read More

Trapped: Cell-invading piece of virus captured in lab by scientists

Scientists try to stay a step ahead of HIV in order to combat drug resistance and to develop better treatments. When a person is infected with HIV, there is an initial burst of virus production. This is when integrase inserts the virus DNA into many human cells, including CD4 T-immune cells, bra... Read More

Experimental Medicine in a Time of Ebola

As the deadly outbreak of Ebola in West Africa continues to claim lives, Wellcome Trust director Dr Jeremy Farrar calls for Africans to be given access to experimental Ebola medication. This joint statement with Prof David Heymann, head of the Chatham House Centre on Global Health Security, and ... Read More

In Hunt For New Antibiotics, Scientists Look At Bacteria In Insects' Stomachs

Pampering leafcutter ants with fragrant rose petals and fresh oranges may seem an unlikely way to rescue modern medicine, but scientists at a lab in eastern England think it's well worth trying.

As the world cries out for new antibiotics, researchers at the John Innes Center (JIC) in Norwich ... Read More

Wild sheep show benefits of putting up with parasites

In the first evidence that natural selection favors an individual's infection tolerance, researchers from Princeton University and the University of Edinburgh have found that an animal's ability to endure an internal parasite strongly influences its reproductive success. Reported in the journal ... Read More

A Symbiont Betrays Its Host

It came as a surprise to me recently to realize how much is known about the immune responses of plants and, moreover, how much there is to know. There is, I found, detailed molecular information about how our botanical cousins defend themselves against the onslaught of infectious agents. Perhaps... Read More

C. difficile Vaccine Proves Safe, 100 Percent Effective In Animal Models

An experimental vaccine protected 100 percent of animal models against the highly infectious and virulent bacterium, Clostridium difficile, which causes an intestinal disease that kills approximately 30,000 Americans annually. The research is published ahead of print in Infection and Immunity.
... Read More

Pictures Considered #19. The Basal End of Bacterial Flagella

The end of bacterial flagella that is near the cell is a marvel of mechanical miniaturization — a molecular wheel that turns, just like the axle of a car. The assembly consists of a stator, the part that holds it in place, and a rotor, the part that turns. The rotor is a beautifully complex str... Read More

Native bacteria block Wolbachia from being passed to mosquito progeny

Native bacteria living inside mosquitoes prevent the insects from passing Wolbachia bacteria -- which can make the mosquitoes resistant to the malaria parasite -- to their offspring, according to a team of researchers.

The team found that Asaia, a type of bacteria that occurs naturally in Ano... Read More

Oddly Microbial: Selfish Genes*

Evolution is largely driven by conflict, not collaboration, according to cell evolutionist Harmit Malik at the Fred Hutchinson Cancer Research Center (FHCRC). Mammalian cells are contentious places, he explains, populated by alien and host genomic sequences fighting for dominance. "In the compet... Read More

Zombie ant fungi manipulate hosts to die on the 'doorstep' of the colony

A parasitic fungus that must kill its ant hosts outside their nest to reproduce and transmit its infection, manipulates its victims to die in the vicinity of the colony, ensuring a constant supply of potential new hosts, according to researchers at Penn State and colleagues at Brazil's Federal U... Read More

Like cling wrap, new biomaterial can coat tricky burn wounds and block out infection

Wrapping wound dressings around fingers and toes can be tricky, but for burn victims, guarding them against infection is critical. Today, scientists are reporting the development of novel, ultrathin coatings called nanosheets that can cling to the body’s most difficult-to-protect contours and ke... Read More

Rethinking The Origin of Species: Discover Magazine Features The Speciation Microbiome Project

From Discover: "Scientists have long known of the important roles played by the microbes on and in our bodies — our microbiomes. These little guys outnumber our own cells 10 to 1, and they help regulate everything from the energy we get out of food to the health of our immune systems. Now, scien... Read More

TWiM #85: Oscillation in the ocean and a Verona integron

Hosts: Vincent RacanielloMichael Schmidt, ... Read More

Early antibiotic exposure leads to lifelong metabolic disturbances in mice

Antibiotic exposure during a critical window of early development disrupts the bacterial landscape of the gut, home to trillions of diverse microbes, and permanently reprograms the body’s metabolism, setting up a predisposition to obesity, according to a new study. Moreover, the research shows t... Read More

It’s Funnier When You’re Right

The mystery of alcoholic fermentations was uncovered in the first half of the 19th century by Cagniard-Latour (1837) in France, and Schwann (1837) and Kützing (1837) in Germany, based on microscopic studies but not without controversy. The great German organic chemist Justus Liebig did not like ... Read More

Bacteria swim with bodies and flagella

Using a new technique to track the swimming motion of a single bacterium, researchers have discovered that the movement of the bacterium’s body — not just thrust from the flagellum — allow movement through fluids. The finding could shed new light on the evolution of cell body shape.

Click "so... Read More

New discovery: Microbes can create dripstones

According to new research humble, microscopic organisms can create dripstones in caves. This illustrates how biological life can influence the formation of Earth’s geology - and the same may be happening right now on other planets in space.

According to traditional textbooks dripstones are cr... Read More

The typhoid fever pathogen uses a cloaking mechanism to evade neutrophil neutralization

Typhoid fever is caused by systemic infection with Salmonella enterica Typhi. In contrast, infection with the closely related bacterium Salmonella enterica Thyphimurium is usually limited to the gut and causes less serious diarrheal disease. Research comparing the two pathogens reveals how S. Ty... Read More
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