By watching brightly glowing HIV-infected immune cells move within mice, researchers at the Icahn School of Medicine at Mount Sinai have shown how infected immune cells latch onto an uninfected sister cell to directly transmit newly minted viral particles. These interactions allow HIV to spread ... Read More
So far in this series I’ve written a good deal about our work on Zika virus, but I have said little about the people who are doing the science.
My lab at Columbia University Medical Center is very small, consisting of three people—Amy Rosenfeld, Audrey Warren, and me. Let me tell you about ... Read More
Researchers have discovered how the bacteria Group B streptococcus (GBS) avoids detection by the immune system during pregnancy. The findings, reported in the journal mBio, could lead to the development of new drugs and strategies for treating GBS infection, which is a leading cause of neonatal ... Read More
Washington, D.C.—June 28, 2016—Researchers determined that two bacterial species commonly found in the human mouth and in abscesses, cooperate to make the pathogenic bacterium, Aggregatibacter actinomycetemcomitans, more infectious. Key to the cooperation is that the harmless partner provides th... Read More
Washington, DC – July 11, 2016 – A team of Italian investigators has discovered a new variant of an emerging antibiotic resistance mechanism. The new variant, dubbed mcr-1.2, confers resistance to colistin, a last-resort antibiotic against multidrug-resistant Gram-negative pathogens. The researc... Read More
Washington, DC – July 18, 2016 - Most bacteria cannot survive in the acidic environment of the human stomach, but Helicobacter pylori, a major cause of ulcers, thrives under such circumstances. Now research has shown that one of that bacterium’s regulatory proteins that helps it adapt to these s... Read More
Particularly in the pharmaceutical industry, microbiological method development and, specifically, method suitability is often overlooked or left until the end of a project. However, it is important to give both method suitability and development due consideration as it can be a complicated proc... Read More
Vincent speaks with Sandy Weller about her career and her work on the mechanisms of synthesis, maturation, cleavage and packaging of viral DNA genomes.
Host: Vincent Racaniello
Guest: ... Read More
Releasing genetically modified mosquitoes appears to have helped reduce cases of dengue in a town in Brazil. The news comes as the US is considering whether to approve the use of the same mosquitoes.
The trial involved Aedes mosquitoes that had been modified to kill off wild mosquitoes of the... Read More
The Centers for Disease Control and Prevention has reported that the wily Neisseria gonorrhoeae bacteria may be developing resistance to the only two antibiotics left that can cure the sexually transmitted disease.
The drugs, azithromycin and ceftriaxone, are used in combination to treat gonorr... Read More
The first case of female-to-male sexual transmission of the Zika virus has occurred in New York City, the Centers for Disease Control and Prevention announced Friday. Up until now, it was thought that the only likely route of sexual transmission was male-to-female or male-to-male.
The surpris... Read More
Currently, scientists think the major contributors to insulin resistance are excess weight and physical inactivity, yet ground-breaking new research by an EU funded European-Chinese team of investigators called MetaHit have discovered that specific imbalances in the gut bacteria can cause insuli... Read More
No one knows for sure how they got there. But the discovery that bacteria that normally live in the gut can be detected in the lungs of critically ill people and animals could mean a lot for intensive care patients.
Today, scientists are reporting that they found gut bacteria in the deepest r... Read More
Michael and Vincent present Spotlights, brief reviews of classic papers in the Journal of Bacteriology, and explain how a single bacterial species can reverse autism-like social deficits in the offspring of obese mice.
A team from the Vetmeduni Vienna and the University of Natural Resources and Life Sciences, Vienna succeeded for the first time in extracting the rare compound cPM from a filamentous fungus, applying a special method. Using this substance leads to increased susceptibility of a resistant pathogen... Read More
The anaerobic, Gram-positive Clostridium difficile is a big problem. It causes rampant diarrhea and tissue necrosis, with more than 150,000 annual cases in the United States alone. Many of the disease manifestations of C. difficile are mediated by two exotoxins that C. difficile produces: TcdA a... Read More